Synthesis and characterization and antibacterial activity of some new transition metal complexes with ciprofloxacin-imine

Sadeek, Sadeek A.; El‐Attar, Mohamed S.; El‐Hamid, Sherif M. Abd

doi:10.4314/bcse.v29i2.9

Cited by 28 publications

(33 citation statements)

References 40 publications

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“…The absence of the band at 255 nm and the shift of the reflection bands to higher values and presence of new bands in the reflection spectra of complexes indicated the formation of their metal complexes. The complexes have new bands in the range from 422 to 525 nm which may be assigned to the ligand to metal charge‐transfer …”

Section: Resultsmentioning

confidence: 99%

Spectroscopic, DFT and antimicrobial activity of Zn(II), Zr(IV), Ce(IV) and U(VI) complexes of N,N‐ chelated 4,6‐bis (4‐chlorophenyl)‐2‐amino‐1,2‐dihydropyridine‐3‐carbinitrile

Sadeek

El‐Hamid

Zordok

2018

Applied Organom Chemis

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Four novel metal complexes of 4,6‐bis (4‐chlorophenyl)‐2‐amino‐1,2‐dihydropyridine‐3‐carbinitrile (H2L) with Zn(II), Zr(IV), Ce(IV) and U(VI) were synthesized. The structure was elucidated using elemental analysis, melting point, molar conductivity; spectroscopic techniques (IR, 1H NMR, UV–Vis., mass spectra) as well as thermo gravimetric analysis. The spectroscopic data proved that H2L chelated with the metal ions as a bidentate ligand through Namino and Ncarbinitrile atoms. The molecular structure of the complexes was determined using density functional theory (DFT). The central metal ion in each complex is six‐coordinate and the angles around it vary from 62.74° to 166.46°; these values agree with distorted octahedral geometry. The calculated total energy of the complexes found in the region – 406.342 to −459.717 au and the dipole moment change from 4.675 to 13.171D. The antibacterial and antifungal activities of the ligand, metal salts and complexes were estimated on some microorganisms. The complexes showed significant antibacterial profile in comparison to the free ligand.

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Section: Resultsmentioning

confidence: 99%

Spectroscopic, DFT and antimicrobial activity of Zn(II), Zr(IV), Ce(IV) and U(VI) complexes of N,N‐ chelated 4,6‐bis (4‐chlorophenyl)‐2‐amino‐1,2‐dihydropyridine‐3‐carbinitrile

Sadeek

El‐Hamid

Zordok

2018

Applied Organom Chemis

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“…The imine group present in such compounds has been shown to be critical in their biological activities. Schiff base ligands are able to coordinate in various oxidation states with many different metals [9]. Amino acids have importance in Schiff base complexes formation in which these can act as ligands due to their physiological and pharmacological activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Schiff bases derived from 2-hydroxy-1- naphth- aldehyde and their tin(II) complexes for antimicribial and antioxidant activities

Neelofar¹,

Ali²,

Khan³

et al. 2018

Bull. Chem. Soc. Eth.

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ABSTRACT.The current studies were designed to prepare tin(II) complexes of various Schiff base derivatives of 2-hydroxy-1-naphthaldehyde (HN) with L-histidine and sulfamethazine have been prepared and characterized by different physiochemical studies such as elemental analysis, atomic absorption, UV-Vis spectra, FTIR spectra, 1 H-NMR, 13 C-NMR and conductance studies. Antimicrobial and antioxidant activities were also calculated. Antibacterial activity was evaluated by the agar-well diffusion method. Two Gram-negative (Klebsiella pneumoniae and Escherichia coli) and three Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis) bacterial strains were used. Antifungal activity was resolute against three fungal strains (Aspergillus niger, Aspergillus flavus and Alternaria solani) by using the agar tube dilution method. The antioxidant activity of ligands and their complexes was measured on the basis of the radical scavenging effect of 1,1-diphenyl-2-picryl-hydrazyl (DPPH)-free radical activity. Ligand HNSM exhibited excellent activities as antibacterial activity (22 mm), antifungal activity (55%) and antioxidant activity (119 ppm).

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“…The singlet signals at δ: 6.47–6.94 ppm were attributed to –HC=N aliphatic, multiplet at δ: 7.01–8.86 ppm to –CH aromatic, and two singlet signals at δ: 10.26 and 11.22 ppm correspond to –OH of phenol and caboxylate groups (Table ) . Also, the 1 H NMR spectra of complexes exhibit a new signal in the range 3.3–3.85 ppm, due to the presence of water molecules in the complexes …”

Section: Resultsmentioning

confidence: 99%

Study on the nematicidal activity and chemical structure of NO bidentate Schiff base some metal complexes

ElAttar

El-Lattif

Sadeek

2019

J Chinese Chemical Soc

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A series of Co(II), Cu(II), Y(III), Zr(IV), La(III), and U(VI) complexes derived from 2-(2-hydroxybenzylidinemine)-benzoic acid (L) ligand were synthesized. The mode of bonding of L and the structure of its metal complexes were investigated using different analytical and spectral tools (FT-IR, UV-Vis, 1 H NMR, mass, and XRD). The ligand chelated with the metal ions as a neutral bidentate through oxygen and azomethine nitrogen atoms. All metal complexes adopted octahedral geometry with characteristic color for metal ions. The results of magnetic moment measurements supported paramagnetic for some complexes (Co(II) and Cu(II)) and diamagnetic phenomena for the other complexes. The thermal decomposition of the ligand along with its metal complexes was explained. The molar conductance values of all complexes in (DMF) were found in the range 154.50 to 250.20 S cm 2 mol −1 at room temperature. The activation thermodynamic parameters, such as E*, ΔH*, ΔS* and ΔG*, were calculated from the DTG curves using Coats-Redfern (CR) and Horowitz-Metzeger (HM) methods at n = 1 or n 6 ¼ 1.The nematicidal activity of the synthesized L and their metal complexes was screened. K E Y W O R D S

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Synthesis and characterization and antibacterial activity of some new transition metal complexes with ciprofloxacin-imine

Cited by 28 publications

References 40 publications

Spectroscopic, DFT and antimicrobial activity of Zn(II), Zr(IV), Ce(IV) and U(VI) complexes of N,N‐ chelated 4,6‐bis (4‐chlorophenyl)‐2‐amino‐1,2‐dihydropyridine‐3‐carbinitrile

Spectroscopic, DFT and antimicrobial activity of Zn(II), Zr(IV), Ce(IV) and U(VI) complexes of N,N‐ chelated 4,6‐bis (4‐chlorophenyl)‐2‐amino‐1,2‐dihydropyridine‐3‐carbinitrile

Synthesis of Schiff bases derived from 2-hydroxy-1- naphth- aldehyde and their tin(II) complexes for antimicribial and antioxidant activities

Study on the nematicidal activity and chemical structure of NO bidentate Schiff base some metal complexes

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