“…Also thiadiazoles were considered as inhibitors of H. pylori urease, however enzymatic studies have not been carried out and this assumption was derived from their antibacterial activity supported by molecular modeling against this enzyme [91] . The combination of two inhibitory scaffolds, namely of benzimidazole with triazole (compound 29 ) or oxadiazole (compound 30 ) [92] , as well as aminopyridine with carbazole (compound 31 ) [93] did not result in elevation of inhibitory activity. Fig.…”
“…Also thiadiazoles were considered as inhibitors of H. pylori urease, however enzymatic studies have not been carried out and this assumption was derived from their antibacterial activity supported by molecular modeling against this enzyme [91] . The combination of two inhibitory scaffolds, namely of benzimidazole with triazole (compound 29 ) or oxadiazole (compound 30 ) [92] , as well as aminopyridine with carbazole (compound 31 ) [93] did not result in elevation of inhibitory activity. Fig.…”
“…On the other hand, compounds 16b , 16c , 16m , and 16o exhibited decent activity against certain fungal organisms at a concentration of 1 mg/mL as compared to the standard drug nystatin. Carbazole derivatives 16m and 16o displayed comparable activity to that of the standard and towards C. albicans and A. niger [ 40 ].…”
Section: Antibacterial and Antifungal Activities Of Carbazole Derivat...mentioning
Microbial infection is a leading cause of death worldwide, resulting in around 1.2 million deaths annually. Due to this, medicinal chemists are continuously searching for new or improved alternatives to combat microbial infections. Among many nitrogen-containing heterocycles, carbazole derivatives have shown significant biological activities, of which its antimicrobial and antifungal activities are the most studied. In this review, miscellaneous carbazole derivatives and their antimicrobial activity are discussed (articles published from 1999 to 2022).
“…Compounds 5m and 5o showed comparable activity with inhibition zone (14 ± 10 and 15 ± 12mm) respectively as that of standard, against C. albicans and A. niger. [50] In 2014, Sharma et al evaluated the antimicrobial activity of a series of new carbazole derivatives (6a-o) (Figure 4.) with oxadiazole moiety is one of the most perceptible pharmacophore integrated at position 9 of carbazole nucleus.…”
Amongst many nitrogen-containing heterocycles, carbazole frame is the building block of various biologically active compounds, including both synthetic and natural products of which its antimicrobial and antifungal activities are the most examined. In this review, 3, 4 and N-substituted carbazole derivatives and their antimicrobial activities are discussed (articles published from 2013 to 2022).
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