Antimicrobial Potential of Carbazole Derivatives

Kadnor, Vijay A.

doi:10.5562/cca3899

Croat. Chem. Acta

2022

DOI: 10.5562/cca3899

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Antimicrobial Potential of Carbazole Derivatives

Vijay A. Kadnor¹

Abstract: Amongst many nitrogen-containing heterocycles, carbazole frame is the building block of various biologically active compounds, including both synthetic and natural products of which its antimicrobial and antifungal activities are the most examined. In this review, 3, 4 and N-substituted carbazole derivatives and their antimicrobial activities are discussed (articles published from 2013 to 2022).

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Cited by 2 publications

References 56 publications

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Synthesis, cytotoxic evaluation, molecular docking studies and drug-likeness analysis of some novel 2-[(9-ethyl-9 H -carbazol-3-yl)imino]thiazoles/thiazolidinones

Hassanin,

Ali,

Abdel-Kariem

2024

Journal of Sulfur Chemistry

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Synthesis, cytotoxic evaluation, molecular docking studies and drug-likeness analysis of some novel 2-[(9-ethyl-9 H -carbazol-3-yl)imino]thiazoles/thiazolidinones

Hassanin,

Ali,

Abdel-Kariem

2024

Journal of Sulfur Chemistry

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A Review of In Vitro Antimicrobial Activities of Carbazole and its Derivative From 2014 to 2022

Kumar,

Sharma,

Nirmal

2023

AIA

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A large number of antibiotics are easily accessible for the treatment of various microbial infections. However, antibiotic resistance has become a major concern to public health across the globe. Carbazole derivatives are present in carbazomycins, an unprecedented class of antibiotics showing potential antibacterial activities. As reported in the literature, carbazole derivatives also possess significant antimicrobial activities against bacterial resistance, such as Methicillin Resistant Staphylococcus aureus (MRSA). The antimicrobial profile of carbazole derivatives has been achieved through various bacterial pathways. Carbazole hybrids based on the multi-target direct ligand (MTDL) approach were also extensively studied as they exhibited significant antibacterial activities. This article reviews antimicrobial potential, docking analysis, and structure-activity relationship (SAR) studies of carbazole and its derivatives against tested bacterial strains from 2014 to 2022. This review can also be helpful for investigators in the design and development of new molecules based on carbazole structure against various resistant bacterial infections.

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Antimicrobial Potential of Carbazole Derivatives

Cited by 2 publications

References 56 publications

Synthesis, cytotoxic evaluation, molecular docking studies and drug-likeness analysis of some novel 2-[(9-ethyl-9 H -carbazol-3-yl)imino]thiazoles/thiazolidinones

Synthesis, cytotoxic evaluation, molecular docking studies and drug-likeness analysis of some novel 2-[(9-ethyl-9 H -carbazol-3-yl)imino]thiazoles/thiazolidinones

A Review of In Vitro Antimicrobial Activities of Carbazole and its Derivative From 2014 to 2022

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