Synthesis and biological evaluation of novel luteolin derivatives as antibacterial agents

Lv, Peng‐Cheng; Li, Huan‐Qiu; Xue, Jia‐Yu; Shi, Lei; Zhu, Hai‐Liang

doi:10.1016/j.ejmech.2008.01.013

Cited by 73 publications

(45 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 2011, Hong et al proved that gallic acid present in a hydrolysable tannin extracted from the bark of Rhizophora apiculata possessed anti-C. albicans activity [32]. Although luteolin has been previously reported to exhibit antimicrobial activity against Bacillus cereus and Salmonella enteritidi [33], and quercetin against Staphylococcus aureus, Escherichia coli and Pseudomonas fluorescens [34], in this work, these phenolic compounds demonstrated a lower effect against all Candida species cells (≥0.625 mg/ml). The highest resistance of C. tropicalis ATCC 750 cells to all the flavonoids in this study (MIC: Figure 1A-D).…”

Section: Resultsmentioning

confidence: 39%

Antifungal Activity of Phenolic Compounds Identified in Flowers from North Eastern Portugal Against Candida Species

et al. 2014

View full text Add to dashboard Cite

Aim: To evaluate the antifungal effect of gallic acid, catechin, luteolin and quercetin, phenolic compounds identified from flowers of North Eastern Portugal, against Candida planktonic and biofilm cells. Materials & methods: The MICs were determined in Candida planktonic cells and the effect of phenolic compounds on Candida biofilms was assessed through quantification of colony-forming units. Results: MIC values demonstrated that gallic acid presented the highest effect against all Candida species. Catechin showed a similar effect against Candida albicans American Type Culture Collection (ATCC) 90028 cells. In addition, gallic acid and quercetin had demonstrated only a minimal effect against Candida species biofilms. Conclusion: Gallic acid affected the growth of the different planktonic Candida species in all concentrations used; still, catechin showed a similar effect against C. albicans ATCC 90028 and Candida glabrata ATCC 2001 cells. In addition, only gallic acid and quercetin demonstrated a slight effect against all Candida species biofilms.

show abstract

Section: Resultsmentioning

confidence: 39%

Antifungal Activity of Phenolic Compounds Identified in Flowers from North Eastern Portugal Against Candida Species

et al. 2014

View full text Add to dashboard Cite

show abstract

“…2 Arima and coworkers demonstrated the synergistic effects of rutin (which has no independent antibacterial activity) on the activity of the flavonoids quercetin and eriodictyol against Bacillus cereus and Salmonella enteritidis. 20 Although luteolin, 21 eriodictyol and quercetin 20 have each previously been reported to exhibit antibacterial activity, 22 it is not known whether their activity against S. aureus is potentiated in the presence of CAPE. Since luteolin did not significantly inhibit growth at the concentrations tested ( Fig.…”

Section: Antibacterial Activity Of Cape and Luteolinmentioning

confidence: 99%

Anti-inflammatory and antibacterial profiles of selected compounds found in South African propolis

Toit¹,

Buthelezi²,

Bodenstein³

2010

S Afr J Sci

View full text Add to dashboard Cite

IntroductionPropolis is a complex resinous substance manufactured by honeybees. It consists of exudates collected from the parts of various plant species, substances secreted from bee metabolism, and materials which are introduced during propolis elaboration. [1][2][3] In general, it is composed of 50% resin and vegetable balsam, 30% wax, 10% essential and aromatic oils, 5% pollen and 5% various other organic substances including debris. Exudates collected from leaves and leaf buds, mucilages, gums, resins and latices contribute the most to the constituents of propolis.2 Of these, the largest group of compounds is the flavonoid pigments, such as luteolin, eriodictyol, galangin and quercetin. Flavonoids are ubiquitous in the plant kingdom, occurring naturally in foods and at concentrations of <0.1-0.7% in propolis.2,4-7 Other non-flavonoid constituents include caffeic acids and their esters (2-20%), such as caffeic acid phenethyl ester (CAPE).

show abstract

“…However, its structurally related compounds, luteolin and a series of its derivatives are welldocumented antibacterial agents against various species, including S. aureus. 57 Luteolin was also characterized as a selective inhibitor to the growth of S. aureus, including MRSA and MSSA, as indicated by an MIC value of 62.5-125 mg/mL. 58 It has also been found to have synergetic effects on MRSA in combination with several quinolones and aminoglycosides antibiotics.…”

mentioning

confidence: 99%

Synergistic antibacterial effects of herbal extracts and antibiotics on methicillin-resistant Staphylococcus aureus: A computational and experimental study

Kuok

Hoi

et al. 2017

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Antibiotic resistant is a well-known threat to global health and methicillin-resistant Staphylococcus aureus is one of the most significant ones. These resistant bacteria kill thousands of people every year and therefore a new effective antimicrobial treatment is necessary. This study identified the herbs and their associated bioactive ingredients that can potential the effects of current antibiotics. These herbs have long history of human usage in China and have well-defined monograph in the Chinese Pharmacopeia. These indicate their relatively high clinical safety and may have a quicker drug development process than that of a new novel antibiotic. Based on the results of this study, the authors will perform further in vitro and animal studies, aiming to accumulate significant data for the application of clinical trial. AbstractAntibiotic resistance has become a serious global concern, and the discovery of antimicrobial herbal constituents may provide valuable solutions to overcome the problem. In this study, the effects of therapies combining antibiotics and four medicinal herbs on methicillinresistant Staphylococcus aureus (MRSA) were investigated. Specifically, the synergistic effects of Magnolia officinalis, Verbena officinalis, Momordica charantia, and Daphne genkwa in combination with oxacillin or gentamicin against methicillin-resistant (ATCC43300) and methicillin-susceptible (ATCC25923) S. aureus were examined. In vitro susceptibility and synergistic testing were performed to measure the minimum inhibitory concentration and fractional inhibitory concentration (FIC) index of the antibiotics and medicinal herbs against MRSA and methicillin-susceptible S. aureus. To identify the active constituents in producing these synergistic effects, in silico molecular docking was used to investigate the binding affinities of 139 constituents of the four herbs to the two common MRSA inhibitory targets, penicillin binding proteins 2a (PBP2a) and 4 (PBP4). The physicochemical and absorption, distribution, metabolism, and excretion properties and drug safety profiles of these compounds were also analyzed. D. genkwa extract potentiated the antibacterial effects of oxacillin against MRSA, as indicated by an FIC index value of 0.375. M. officinalis and V. officinalis produced partial synergistic effects when combined with oxacillin, whereas M. charantia was found to have no beneficial effects in inhibiting MRSA. Overall, tiliroside, pinoresinol, magnatriol B, and momorcharaside B were predicted to be PBP2a or PBP4 inhibitors with good drug-like properties. This study identifies compounds that deserve further investigation with the aim of developing therapeutic agents to modulate the effect of antibiotics on MRSA.

show abstract

Synthesis and biological evaluation of novel luteolin derivatives as antibacterial agents

Cited by 73 publications

References 17 publications

Antifungal Activity of Phenolic Compounds Identified in Flowers from North Eastern Portugal Against Candida Species

Antifungal Activity of Phenolic Compounds Identified in Flowers from North Eastern Portugal Against Candida Species

Anti-inflammatory and antibacterial profiles of selected compounds found in South African propolis

Synergistic antibacterial effects of herbal extracts and antibiotics on methicillin-resistant Staphylococcus aureus: A computational and experimental study

Contact Info

Product

Resources

About