Antifungal Activity of Phenolic Compounds Identified in Flowers from North Eastern Portugal Against Candida Species

Abstract

Aim: To evaluate the antifungal effect of gallic acid, catechin, luteolin and quercetin, phenolic compounds identified from flowers of North Eastern Portugal, against Candida planktonic and biofilm cells. Materials & methods: The MICs were determined in Candida planktonic cells and the effect of phenolic compounds on Candida biofilms was assessed through quantification of colony-forming units. Results: MIC values demonstrated that gallic acid presented the highest effect against all Candida species. Catechin showed a similar effect against Candida albicans American Type Culture Collection (ATCC) 90028 cells. In addition, gallic acid and quercetin had demonstrated only a minimal effect against Candida species biofilms. Conclusion: Gallic acid affected the growth of the different planktonic Candida species in all concentrations used; still, catechin showed a similar effect against C. albicans ATCC 90028 and Candida glabrata ATCC 2001 cells. In addition, only gallic acid and quercetin demonstrated a slight effect against all Candida species biofilms.

Antifungal Activity of Extracts and Isolated Compounds from Buchenavia Tomentosa on Candida Albicans and non- albicans

“…NA: Not available. been proposed that it may act by a disruption of fungi membrane preventing the development of cells [40]. The antifungal effect of gallic acid on Candida albicans and non-albicans was found in previous studies [40][41][42].…”

“…Gallic acid is considered a promising antifungal agent in the literature [40]. Its mechanism of action is not fully understood, but it has The concentration required to inhibit the growth in the 50 and 90% of samples (MIC 50 and MIC 90 , respectively) was showed only for clinical species presenting more than ten samples accordingly to Schwarz et al [21].…”

“…Examples include gallic acid [40][41][42], kaempferol [43,44], (-)epicatechin [45], ellagic acid [41,42,[46][47], vitexin [44] and corilagin [41,48]. The antifungal activity on Candida species of these compounds was investigated.…”

In vitro antifungal activity of baicalin against Candida albicans biofilms via apoptotic induction

“…matrine [39], oxymatrine [40], gallic acid [41]), but usually owned nice in vivo antifungal functions (e.g. sodium houttuyfonate [42], baicalein [43]).…”

Antibacterial, antifungal and anti-inflammatory activities of <i>Melia azedarach</i> ethanolic leaf extract

“…Other phenolics present-even in lower doses-in our extract could contribute to the observed fungicidal and microbial effects such as gallic acid which had been proven to possess bactericidal and antifungal activity against F. solani (Nguyen et al, 2015) and Candida species (Alves et al, 2014). Therefore, syringic acidknown to have antimicrobial activity and fungitoxicityas proven against Gano derma boninense by Chong et al (2012) could result in observed antimicrobial effects.…”