Synthesis and application of the MCM-41 and SBA-15 as matrices for in vitro efavirenz release study

Jesus, Roberta Anjos de; Rabelo, Alessandra Silva; Figueiredo, Renan Tavares; Silva, L.C. Cides da; Codentino, I.C.; Fantini, M.C.A.; Araújo, Gabriel Lima Barros de; Araújo, A. A. S.; Mesquita, Maria Eliane de

doi:10.1016/j.jddst.2015.11.008

Cited by 25 publications

(10 citation statements)

References 23 publications

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“…The XRD pattern shows three peaks, which could be indexed as (100), (110), and (200) diffractions of the highly ordered two-dimensional hexagonal mesoporous structure. The results are in good agreement with previous reports [18]. The specific surface area of the samples was measured using a BET method with N 2 adsorption-desorption at −196 • C (Supporting Information Figure S3).…”

Section: Resultssupporting

confidence: 91%

Development and application of SBA‐15 assisted electromembrane extraction followed by corona discharge ion mobility spectrometry for the determination of Thiabendazole in fruit juice samples

Nilash

Mirzaei

Fakhari

2019

J of Separation Science

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A new sample preparation method based on SBA‐15 assisted electromembrane extraction coupled with corona discharge ion mobility spectrometer was developed for the determination of Thiabendazole as a model basic pesticide in fruit juice samples. The addition of SBA‐15 in the supported liquid membrane in electromembrane extraction system not only can lead to enhancement of the effective surface area, but also introducing the negatively charged silanol groups into supported liquid membrane might improve migration of positively charged analytes toward the supported liquid membrane and finally into the acceptor solution. To investigate the effect of the presence of SBA‐15 in the supported liquid membrane on the extraction efficiency, a comparative study was carried out between the conventional electromembrane extraction and SBA‐15/electromembrane extraction methods. Under the optimized conditions, SBA‐15/electromembrane extraction method showed higher extraction efficiencies in comparison with conventional electromembrane extraction method. SBA‐15/electromembrane extraction method exhibited a low limit of detection (0.9 ng/mL), high preconcentration factor (167) and high recovery (83%). Finally, the applicability of SBA‐15/electromembrane extraction method was studied by the extraction and determination of Thiabendazole as a model basic pesticide in fruit juice samples.

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Section: Resultssupporting

confidence: 91%

Development and application of SBA‐15 assisted electromembrane extraction followed by corona discharge ion mobility spectrometry for the determination of Thiabendazole in fruit juice samples

Nilash

Mirzaei

Fakhari

2019

J of Separation Science

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“…In samples of α‐tocopherol/M1, α‐tocopherol/M2, α‐tocopherol/M3, and α‐tocopherol/M4, the intensity of all peaks decreased as compared with that of M1 to M4; this corresponds to the reduction of long‐range ordering of MCM‐41 samples after being loaded with active compound. Similar results have been found in other literature 29–31 . On the other hand, although height decreases, all the peaks of M1 to M4 are kept in XRD patterns of α‐tocopherol‐loaded samples, meaning that the ordered structures of mesoporous materials are quite stable and have been preserved substantially even after being loaded with α‐tocopherol.…”

Section: Resultssupporting

confidence: 89%

Characterization of α‐tocopherol‐loaded MCM‐41 mesoporous silica with different pore sizes and antioxidant active packaging films

Sun

Pan

et al. 2020

Packag Technol Sci

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Antioxidant active packaging films were prepared with low-density polyethylene (LDPE) being incorporated with α-tocopherol-loaded MCM-41 mesoporous silica. In order to study the influence of pore size and morphology of the mesoporous material on physical and release properties of films, the mesoporous materials were synthesized with various pore sizes and morphologies. MCM-41 mesoporous silica materials before and after being loaded with α-tocopherol were characterized, as well as the active films. The results show that physical properties and release profiles of active films can be changed when being incorporated with mesoporous materials with different structures: crystallinity of films prepared ranged from 11.30% to 18.13%, and the tendency of change was in good accordance with that of specific surface area of mesoporous silica materials. Variation of release rates of the antioxidant in packaging films can be achieved by changing MCM-41 pore size, and the release period can be prolonged by 64% in the scope of this study. These demonstrate that LDPE/α-tocopherol/MCM-41 films with adjustable release profile and physical properties have the potential to be used as antioxidant active packaging films.

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“…Among them, MCM41 exhibiting a long-range ordered pore structure is the most widely used type of silica-based materials for drug delivery, and are discovered to enhance the dissolution rate of a series of hydrophobic drugs, including ibuprofen, efavirenz, telmisartan, etc. (Wang et al., 2015 ; Jesus et al., 2016 ; Izquierdo-Barba et al., 2009 ; Horcajada et al., 2004 ; Wang et al., 2014 ). By using an amphiphilic triblock copolymer Pluronic P123 as a template, SBA15 with large mesopores (pore size: 5–30 nm) was obtained.…”

Section: Introductionmentioning

confidence: 99%

“…By using an amphiphilic triblock copolymer Pluronic P123 as a template, SBA15 with large mesopores (pore size: 5–30 nm) was obtained. Benefiting from the wide mesopores, drug could release from SBA15 faster compared to MCM41, and a different dynamic release performance was observed (Jesus et al., 2016 ; Izquierdo-Barba et al., 2009 ). Meanwhile, Li et al developed a drug delivery system involving MSNs with bimodal nanoporous, and the in vitro release study suggested two phases controlled release behavior including an immediate release from the enlarged nanopores and a second dissolution phase from the smaller mesoscopic channels (Li et al., 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis of PEI-based crystalline templated mesoporous silica with molecular chirality for improved oral delivery of the poorly water-soluble drug

et al. 2021

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The aim of this study was to build up a novel chiral mesoporous silica called PEIs@TA-CMS through a facile biomimetic strategy and to explore its potential to serve as a drug carrier for improving the delivery efficiency of poorly water-soluble drug. PEIs@TA-CMS was synthesized by using a chiral crystalline complex associated of tartaric acid and polyethyleneimine (PEIs) as templates, scaffolds and catalysts. The structural features including morphology, size, pore structure and texture properties were systematacially studied. The results showed that PEIs@TA-CMS was monodispersed spherical nanoparticles in a uniformed diameter of 120–130 nm with well-developed pore structure (S BET : 1009.94 m 2 /g, pore size <2.21 nm). Then PEIs@TA-CMS was employed as nimodipine (NMP) carrier and compared with the drug carry ability of MCM41. After drug loading, NMP was effectively transformed from the crystalline state to an amorphous state due to the space confinement in mesopores. As expected, PEIs@TA-CMS had superiority in both drug loading and drug release compared to MCM41. It could incorporate NMP with high efficiency, and the dissolution-promoting effect of PEIs@TA-CMS was more obvious because of the unique interconnected curved pore channels. Meanwhile, PEIs@TA-CMS could significantly improve the oral adsorption of NMP to a satisfactory level, which showed approximately 3.26-fold higher in bioavailability, and could effectively prolong the survival time of mice on cerebral anoxia from 10.98 to 17.33 min.

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Synthesis and application of the MCM-41 and SBA-15 as matrices for in vitro efavirenz release study

Cited by 25 publications

References 23 publications

Development and application of SBA‐15 assisted electromembrane extraction followed by corona discharge ion mobility spectrometry for the determination of Thiabendazole in fruit juice samples

Development and application of SBA‐15 assisted electromembrane extraction followed by corona discharge ion mobility spectrometry for the determination of Thiabendazole in fruit juice samples

Characterization of α‐tocopherol‐loaded MCM‐41 mesoporous silica with different pore sizes and antioxidant active packaging films

Facile synthesis of PEI-based crystalline templated mesoporous silica with molecular chirality for improved oral delivery of the poorly water-soluble drug

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