Synthesis and antitumor activity of doxorubicin conjugated stearic acid-g-chitosan oligosaccharide polymeric micelles

Hu, Fuqiang; Liu, Lina; Du, Yong‐Zhong; Yuan, Hong

doi:10.1016/j.biomaterials.2009.09.008

Cited by 229 publications

(158 citation statements)

References 27 publications

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“…(Zhang et al, 2007). The anticancer mechanism of DOX may be attributed to its interactions with DNA by the intercalation model, which inhibits the synthesis of nucleic acids (Hu et al, 2009). However, cardiac toxicity and myelosuppression are the main side effects of chemotherapy (Oh et al, 1999;Octavia et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Quantification of DOX bioavailability in biological samples of mice by sensitive and precise HPLC assay

Zhang

Dong³

et al. 2015

Pharmaceutical Biology

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Results: The t 1/2 values of DOX/P(HB-HO) NPs and DOX/FA-PEG-P(HB-HO) NPs were 2.7-and 3.5-times higher than that of free DOX. No significant difference (p40.05) was found in C max between the NPs and free DOX. The T max values of the two NPs were prolonged from 0.25 to 1 h. The AUC 0-t values were 1.55-and 3.05-folds higher than that of free DOX, and MRT increased to 15.99 h for DOX/P(HB-HO) NPs and 25.14 h for DOX/FA-PEG-P(HB-HO) NPs. For DOX/FA-PEG-P(HB-HO) NPs, the DOX content in the tumors were 10.81-and 3.33-times higher than those for free DOX and DOX/P(HB-HO) NPs at 48 h, respectively. Discussion and conclusions: DOX/FA-PEG-P(HB-HO) NPs displayed reduced cardiac toxicity and improved bioavailability. Moreover, the NPs exhibited a significant extent of DOX accumulation in the tumors, thus suggesting that folate-targeted NPs could effectively transport into HeLa tumors with satisfying targeting.

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Section: Introductionmentioning

confidence: 99%

Quantification of DOX bioavailability in biological samples of mice by sensitive and precise HPLC assay

Zhang

Dong³

et al. 2015

Pharmaceutical Biology

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“…The value of the CMC was about 0.14 mg/mL, which was consistent with previous results. 28,31 This low CMC meant that CSO-SA could easily self-assemble to form micelles in aqueous medium and keep the core-shell structure, even under highly diluted conditions.…”

Section: Preparation and Characteristics Of Cso-sa Micelles And Oxa-lmentioning

confidence: 99%

“…The characteristics of micelles were consistent with previous studies. 28 The reduced drug accumulation was considered as a defense mechanism of tumor cells against Pt drug. To investigate the enhanced cytotoxicity and reversal of drug resistance of CSO-SA/OXA micelles, dissociated spheroids of HT29 and SW620 were exposed to OXA or CSO-SA/OXA micelles at different incubation times, and the Pt content was then determined using ICP-MS.…”

Section: Oxa-loaded Cso-sa Micelles Enhancing Pt Accumulation In Cancmentioning

confidence: 99%

“…Furthermore, micelle encapsulation of drug was studied to improve the antitumor activity and reverse multidrug resistance in xenograft tumors. [27][28][29][30] For example, a CSO-SA-based polymeric nanosystem for oxaliplatin (OXA) loading has recently been reported to have obvious antiproliferative effects against breast cancer cells in vitro. 31 However, the antitumor activity of OXA-loaded micellar nanoparticles in a CRC model has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

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Oxaliplatin-incorporated micelles eliminate both cancer stem-like and bulk cell populations in colorectal cancer

Wang

Liu

Zhang³

et al. 2011

IJN

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Purpose:The failure of cancer treatments is partly due to the enrichment of cancer stem-like cells (CSLCs) that are resistant to conventional chemotherapy. A novel micelle formulation of oxaliplatin (OXA) encapsulated in chitosan vesicle was developed. The authors postulate that micelle encapsulation of OXA would eliminate both CSLCs and bulk cancer cells in colorectal cancer (CRC). Experimental design: In this study, using stearic acid-g-chitosan oligosaccharide (CSO-SA) polymeric micelles as a drug-delivery system, OXA-loaded CSO-SA micelles (CSO-SA/OXA) were prepared. Intracellular uptake of CSO-SA/OXA micelles was assessed by confocal microscope. The effects of free OXA, the empty carrier, and CSO-SA/OXA micelles were tested using human CRC cell lines in vitro and in vivo. Results: The micelles showed excellent internalization ability that increased OXA accumulation both in CRC cells and tissues. Furthermore, CSO-SA/OXA micelles could either increase the cytotoxicity of OXA against the bulk cancer cells or reverse chemoresistance of CSLC subpopulations in vitro. Intravenous administration of CSO-SA/OXA micelles effectively suppressed the tumor growth and reduced CD133 + /CD24+ cell (putative CRC CSLC markers) compared with free OXA treatment, which caused CSLC enrichment in xenograft tumors (P , 0.05). Conclusion:The results of this study indicate that CSO-SA micelle as a drug-delivery carrier is effective for eradicating CSLCs and may act as a new option for CRC therapy.

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“…Of all pH-responsive bonds, the most important are hydrazone, acetal, [14][15][16] and cis-aconityl. [17][18][19][20] As the preferred pH-responsive chemical bond, hydrazone has been extensively studied, owing to its acute response in drug delivery behavior.…”

Section: Introductionmentioning

confidence: 99%

A pH-responsive prodrug delivery system of 10-HCPT for controlled release and tumor targeting

Liu¹,

Li²,

Guo³

et al. 2017

IJN

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Synthesis and antitumor activity of doxorubicin conjugated stearic acid-g-chitosan oligosaccharide polymeric micelles

Cited by 229 publications

References 27 publications

Quantification of DOX bioavailability in biological samples of mice by sensitive and precise HPLC assay

Quantification of DOX bioavailability in biological samples of mice by sensitive and precise HPLC assay

Oxaliplatin-incorporated micelles eliminate both cancer stem-like and bulk cell populations in colorectal cancer

A pH-responsive prodrug delivery system of 10-HCPT for controlled release and tumor targeting

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