Synthesis and Antimicrobial Evaluation of Novel Dibenzo‐18‐Crown‐6‐Ether Functionalized Pyrimidines

Abstract

in Wiley Online Library (wileyonlinelibrary.com).A practical, two-step synthesis of crown ether functionalized pyrimidines has been developed. The reaction conditions have been optimized, and the protocol is generalized for series of substrates. These newly synthesized compounds exhibited antimicrobial activity against bacterial strains Staphylcoccus aureus (Gram-positive) and Escherichia coli (Gram-negative). These compounds were also found to be potent antifungal agents Aspergillus niger and Candida albicans strains, respectively.

Synthesis, characterization, and antimicrobial activities of novel double-armed benzo-15-crown-5 and their sodium and potassium complexes

“…12,[16][17][18][19][20][21][22][23] Their complexing properties make crown ethers especially interesting and useful compounds in biological research and in chemistry. [24][25][26][27][28][29][30][31] The ion complex-carrying ability of crown ethers results in them resembling natural ionophores (such as gramicidin). In this context, similar to natural ionophores, their ability to transport ions through lipid membranes by channeling has enabled the use of crown ethers in various biological applications.…”

Ag2O on ZrO2 as a Recyclable Catalyst for Multicomponent Synthesis of Indenopyrimidine Derivatives

“…Owing to their economic viability and scientific importance, methodologies have been described for the synthesis of various types of substituted pyrimidines. Diverse catalytic systems such as NaOH, references [ 20 , 21 , 22 ] sodium methoxide [ 23 ], 1-sulfonic acid-3-methyl imidazolium ferric chloride/NaY [ 24 ], α-Fe 2 O 3 -MCM-41-P [ 25 ], and uranyl acetate/succinimide sulfonic acid [ 26 ] have been used in the synthesis of pyrimidine derivatives. However, these protocols invariably demand expensive reagents, high energy input, and lengthy reaction times.…”