Synthesis and Antihistaminic H1 Activity of 1,2,5(6)-Trisubstituted Benzimidazoles

Göker, Hakan; Ayhan-Kılcıgi̇l, Gülgün; Tunçbìlek, Meral; Kuş, Canan; Ertan, Rahmiye; Kendi, Engin; Özbey, Süheyla; Fort, M.; Garcia, Celia; Farré, A.J.

doi:10.3987/com-99-8585

Cited by 40 publications

(25 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TLC was used for monitoring the progress of the reaction; the structures of products were assessed by interpretation of obtained spectra. The spectroscopic data of IR, 1 H-NMR, 13 C-NMR, mass spectra and elemental analysis were in agreement with the structure of the synthesized compounds.…”

Section: Resultssupporting

confidence: 55%

“…Both heteroatoms are nitrogen (N), which are present at non-adjacent position [3]. The benzimidazole moiety is an important heterocyclic ring, a wide variety of benzimidazole derivatives are known for their chemotherapeutic importance and antimicrobial activities [4][5][6][7][8][9], antifungal activity [10][11][12], anti-inflammatory [13] and antioxidant [14][15][16][17][18] in this context. Due to great potential of the moiety, synthesis of benzimidazole derivatives was carried out to evaluate their antimicrobial.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis, characterization and antibacterial evaluation of some novel derivatives of 2-bromomethyl-benzimidazole

Ahmadi¹

2014

Bull. Chem. Soc. Eth.

View full text Add to dashboard Cite

ABSTRACT. In the present study, synthesis, and biological evaluation of some novel derivatives of 2-bromomethyl-benzimidazole were investigated. The structures of the new synthesized compounds were characterized by IR, 1 H-NMR, 13 C-NMR, mass spectrometry and elemental analysis and screened for antimicrobial activity against two Gram-positive strains (Staphylococcus aureus and Bacillus subtilis) and two Gram-negative strains (Escherichia coli and Pseudomonas aeruginosa). Results indicate that new compounds showed moderate to good activity when compared with standard antibiotic Ciprofloxacin and Streptomycin.

show abstract

Section: Resultssupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and antibacterial evaluation of some novel derivatives of 2-bromomethyl-benzimidazole

Ahmadi¹

2014

Bull. Chem. Soc. Eth.

View full text Add to dashboard Cite

show abstract

“…Compounds bearing benzimidazole moiety are reported to possess a number of interesting biological activities such as antitubercular [1], anticancer [2], antihelmintic [3], antiallergic [4], antioxidant [5], antihistaminic [6]. These also exhibit antibacterial, antifungal and antiviral activities [7].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, DNA Binding and Cleavage Studies of Mixed-Ligand Cu(II) Complexes of 2,6-bis(benzimidazol-2-yl)pyridine

et al. 2012

View full text Add to dashboard Cite

Four novel copper(II) complexes of the composition [CuLX] where L = 2,6-bis(benzimidazole-2yl)pyridine, X = dipyridophenazine (L1), 1,10-phenanthroline (L2), hydroxyproline (L3) and 2,6-pyridine dicarboxylic acid (L4) were synthesized and characterized by using elemental analysis, FT-IR, UV–vis, ESI-MS, molar conductance and magnetic susceptibility measurements. The complexes [CuLL1](NO3)2 [1], [CuLL2](NO3)2 [2], [CuLL3](NO3) [3] and [CuLL4] (NO3) [4] are stable at room temperature. In DMSO the complexes [1] and [2] are 1:2 electrolytes, [3] and [4] are 1:1 electrolytes. Based on elemental and spectral studies five coordinated geometry is assigned to all the four complexes. The interaction of four copper ion complexes with calf thymus DNA were carried out by UV-vis titrations, fluorescence spectroscopy, thermal melting and viscosity measurements .The binding constant (K(b)) of the above four metal complexes were determined as 5.43 × 10(4) M(-1), 2.56 × 10(4) M(-1), 1.21 × 10(4) M(-1) and 1.57 × 10(4) M(-1) respectively. Quenching studies of the four complexes indicates that these complexes strongly bind to DNA, out of all complex 1 is binding more strongly. Viscosity measurements indicate the binding mode of complexes with CT DNA by intercalation through groove. Thermal melting studies also support intercalative binding. The nuclease activity of the above metal complexes shows that 1, 2 and 3 complexes cleave DNA through redox chemistry.

show abstract

“…A literature survey indicates that benzimidazole derivatives possess different pharmacological and biological properties like antibacterial, anti-inflammatory, antifungal, anti-tubercular, anticancer, anthelmintic activity, etc. Combination of two or more active moieties into one is a common procedure of manipulation and this can possibly results in augmenting the activity, removal of untoward side effects and particularly prevent the development of resistance by the infectious micro-organisms [9][10][11][12][13][14]. Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antibacterial evaluation of some novel mannich bases of benzimidazole derivatives

Ahmadi¹

2017

Bull. Chem. Soc. Eth.

View full text Add to dashboard Cite

ABSTRACT. Substituted benzimidazoles are known for their chemotherapeutic importance and many pharmacological properties. In this paper, we synthesized some novel Mannich bases of benzimidazole derivatives. The synthesized compounds were characterized by their physical and spectral data and in vitro antibacterial activity of these compounds tested against Bacillus subtilis, Bacillus pumilus, Escherichia coli and Pseudomonas aeruginosa organisms. The potency of the synthesized compounds was determined against standard drug Ciprofloxacin by measuring the zone of inhibition.

show abstract

Synthesis and Antihistaminic H1 Activity of 1,2,5(6)-Trisubstituted Benzimidazoles

Cited by 40 publications

References 10 publications

Synthesis, characterization and antibacterial evaluation of some novel derivatives of 2-bromomethyl-benzimidazole

Synthesis, characterization and antibacterial evaluation of some novel derivatives of 2-bromomethyl-benzimidazole

Synthesis, Characterization, DNA Binding and Cleavage Studies of Mixed-Ligand Cu(II) Complexes of 2,6-bis(benzimidazol-2-yl)pyridine

Synthesis and antibacterial evaluation of some novel mannich bases of benzimidazole derivatives

Contact Info

Product

Resources

About