Synthesis, characterization and antibacterial evaluation of some novel derivatives of 2-bromomethyl-benzimidazole

Ahmadi, Abbas

doi:10.4314/bcse.v28i3.14

Cited by 6 publications

(4 citation statements)

References 14 publications

(15 reference statements)

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“…The chemicals used are obtained from SD Fine Chemicals Limited, Mumbai, and are of AR grade. Compounds were synthesized, identified, and characterized by following methods such as melting point determination, thin layer chromatography, and infrared spectroscopy [8][9][10].…”

Section: Methodsmentioning

confidence: 99%

Synthesis, in silico studies and antibacterial activity of some novel 2-substituted benzimidazole derivatives

Chintakunta¹,

Meka²

2020

Futur J Pharm Sci

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Background The o-phenylenediamine is a versatile starting material for several compounds. Synthesized o-phenylenediamine and amino acids (glycine, alanine, aspartic acid, and l-proline) undergo condensation via Phillips reaction. The synthesized compound showed the promising antibacterial activity of Bacillus subtilis and Pseudomonas aeruginosa at the concentration of 100, 50, 25, 12.5, 6.25, 3.12, 1.6, 0.8, 0.4, and 0.2 μg/ml. Ciprofloxacin was used as standard drug. Synthesis of benzimidazole derivatives was carried out and purified by recrystallization process using ethanol. Substituted derivatives were characterized by melting point, TLC and spectroscopic methods include FT-IR and 1H-NMR. Results In silico studies were adopted for synthetic derivatives by Molinspiration, ChemDraw, and online software tool. Minimum inhibitory concentration (MIC) values of B. subtilis and P. aeruginosa were reported, and benzimidazole ligands and Molinspiration scores were generated and listed. Conclusion The more negative values indicate a higher binding affinity. The generated ligand observations can be visualized. Physical constants of synthesized derivates such as solubility and melting point were determined. Bioactivity scores were noted for different derivatives and predicted percentage absorption in the gut. The antibacterial activity was performed using the MIC method (aerobic).

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Section: Methodsmentioning

confidence: 99%

Synthesis, in silico studies and antibacterial activity of some novel 2-substituted benzimidazole derivatives

Chintakunta¹,

Meka²

2020

Futur J Pharm Sci

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“…The product was filtered and dried and is recrystalized by ethanol [15]. White needle crystals; yield 73%; m.p.…”

Section: -Mercapto Benzimidazole (I)mentioning

confidence: 99%

Synthesis and antibacterial evaluation of some novel mannich bases of benzimidazole derivatives

Ahmadi¹

2017

Bull. Chem. Soc. Eth.

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ABSTRACT. Substituted benzimidazoles are known for their chemotherapeutic importance and many pharmacological properties. In this paper, we synthesized some novel Mannich bases of benzimidazole derivatives. The synthesized compounds were characterized by their physical and spectral data and in vitro antibacterial activity of these compounds tested against Bacillus subtilis, Bacillus pumilus, Escherichia coli and Pseudomonas aeruginosa organisms. The potency of the synthesized compounds was determined against standard drug Ciprofloxacin by measuring the zone of inhibition.

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“…The results were expressed as mean±SD and statistical analysis was performed by means of student's t-test or by one-way analysis of variance followed by the Dunnett's test for multiple comparisons of unpaired data. Statistically, a p value of less than 0.05 was considered to be significant and a p value of less than 0.01 was considered to be very significant [9,10].…”

Section: Pharmacological Methodsmentioning

confidence: 99%

Synthesis, characterization and anti-inflammatory evaluation of novel derivatives of Trolox with pharmacological alcohol and amines

Ahmadi¹

2017

Bull. Chem. Soc. Eth.

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ABSTRACT. In order to explore the novel anti-inflammatory agents, some novel Trolox derivatives were synthesized and characterized by IR, 1 H-NMR, 13 C-NMR, mass and elemental analysis. The anti-inflammatory activities of the target compounds were evaluated via the croton oil-induced ear oedema test in Swiss mice. According to screened results, obtained compounds demonstrated considerable anti-inflammatory action.

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Synthesis, characterization and antibacterial evaluation of some novel derivatives of 2-bromomethyl-benzimidazole

Cited by 6 publications

References 14 publications

Synthesis, in silico studies and antibacterial activity of some novel 2-substituted benzimidazole derivatives

Synthesis, in silico studies and antibacterial activity of some novel 2-substituted benzimidazole derivatives

Synthesis and antibacterial evaluation of some novel mannich bases of benzimidazole derivatives

Synthesis, characterization and anti-inflammatory evaluation of novel derivatives of Trolox with pharmacological alcohol and amines

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