Synthesis and antibacterial evaluation of some novel mannich bases of benzimidazole derivatives

In the present work, the ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate (3) was subjected to a series of heterocyclization reactions through its reaction with different chemical reagents. The resulting molecules were thiophene, pyrazole, coumarin derivatives incorporated benzo[d]imidazole moiety. All the synthesized compounds were determined by elemental analysis, 1 H NMR, 13 C NMR, and MS. The antitumor evaluations of the newly synthesized products toward the three cancer cell lines MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer) showed that compounds 5a, 9b, 9c, 17, 23b and 38 were of the highest potencies among the synthesized compounds.

Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The uses of ethyl 2-(1H-benzo[D]imidazol-2-yl)acetate to synthesis pyrazole, thiophene, pyridine and coumarin derivatives with antitumor activities

Mohareb¹,

Gamaan²

2018

“…Intriguingly, azo linked substituted benzimidazole, benzoxazole, and benzothiazole synthesized by Mishra et al [12] through diazo coupling also exhibited in vitro antibacterial activity against Staphylococcus aureus and Escherichia Coli strains. Mannich bases of benzimidazole derivatives have also shown in vitro antibacterial activity against Bacillus subtilis, Bacillus pumilus, Escherichia coli and Pseudomonas aeruginosa organisms [13].…”

Section: Biological Activitymentioning

confidence: 99%

Synthesis and pharmacological screening of new isatin-3-[N2-(benzimidazol-1- acetyl)]hydrazone

Chaithanya¹,

Kasiviswanath²,

Chary³

2019

Twenty new isatin-3-[N 2 -(benzimidazol-1-acetyl)]hydrazones (IV) were synthesized from ten different isatin-3-[N 2 -(chloroacetyl)] hydrazones (III) by reacting with benzimidazole and 2-methyl benzimidazole. The intermediates were obtained from isatin hydrazones (II) on condensation with chloroacetyl chloride. These compounds were characterized by IR, 1 H NMR and mass spectra. All the compounds were screened for antimicrobial, antioxidant and cytotoxic activity. Some of the new compounds showed promising antibacterial and antifungal activity.

“…It is an important biologically active heterocyclic compound. The chemistry of benzimidazole and its derivatives has been of great interest to medicinal chemists owing to their remarkable antimicrobial [1], antibacterial [2], antioxidant [3], anticancer [4], anthelmintic [5], cytotoxic [6], analgesic [7], antiulcer [8], antiviral [9] and anticonvulsant [10] activities. The antifungal [11], antimicrobial [12], antioxidant [13] and catalytic [14] activities of transition metal complexes with benzimidazole have also been extensively studied.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectral, thermal, kinetic and antibacterial studies of transition metal complexes with benzimidazolyl-2-hydrazones of o-hydroxyacetophenone, o-hydroxybenzophenone and o-vanillin

Mohapatra¹,

Das²,

El-ajaily³

et al. 2018

A novel series of Schiff base metal complexes of the type [M(L)2].nH2O, where L= 2-(αmethylsalicylidenehydrazino) benzimidazole (L1), 2-(α-phenylsalicylidenehydrazino)benzimidazole (L2), 2-(o-vanillinidenehydrazino)benzimidazole (L3), M = Cu(II), Co(II), Ni(II) and Zn(II), have been synthesized and characterized. The results are in consistent with tridentate chelation of ligand with azomethine nitrogen, ring nitrogen and a deprotonated phenolic oxygen atom. All these compounds have been screened for their antibacterial activities against B. subtilis, B. stearothermophilus, E. coli and S. typhi.