Synthesis and anticancer properties of gold(I) and silver(I) N-heterocyclic carbene complexes

Siciliano, Tammy J.; Deblock, Michael C.; Hindi, Khadijah M.; Durmus, Semih; Panzner, Matthew J.; Tessier, Claire A.; Youngs, Wiley J.

doi:10.1016/j.jorganchem.2010.10.054

Cited by 108 publications

(66 citation statements)

References 37 publications

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“…1B). 22 Herein, we report the preparation of a range of chelating and macrocyclic bis-imidazolium precursors and their coordination to form cationic silver bis (NHC) complexes (Fig. 3).…”

Section: Introductionmentioning

confidence: 99%

Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

et al. 2012

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“…1B). 22 Herein, we report the preparation of a range of chelating and macrocyclic bis-imidazolium precursors and their coordination to form cationic silver bis (NHC) complexes (Fig. 3).…”

Section: Introductionmentioning

confidence: 99%

Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

et al. 2012

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“…• C and high yields of isolated product were obtained (Table, entries [14][15][16][17][18][19]. These results indicate that the use of volatile solvents in the three-component coupling reactions could be avoided and thus it can be considered to provide an important contribution to reducing environmental pollution.…”

Section: Catalytic Activity Of the Nhc Silver Complexesmentioning

confidence: 78%

Ag(I) complexes of benzimidazol-2-ylidene ligands: a study of catalytic efficiency towards three-component coupling reactions

Kılınçarslan¹,

Sadıç²,

Çetınkaya³

2016

Turk J Chem

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Abstract:The N -heterocyclic carbene (NHC)-Ag(I) complexes 3a-c were synthesized from benzimidazolium chlorides (2a-c = NHC.HCl), incorporating benzyl derivatives and a 2-methoxyethyl group (a: 3 N = 2,4,6-trimethylbenzyl; b:3 N = 2,3,5,6-tetramethylbenzyl; c: 3 N = pentamethylbenzyl). The compounds were characterized by spectroscopic and elemental analyses. The synthesized NHC-Ag(I) complexes (3a-c) were tested as catalysts for the catalytic threecomponent coupling reaction of aldehyde, alkyne, and amine to propargylamines in various solvents. All complexes were active catalysts for catalytic three-component coupling reactions with good yields under neat and mild conditions (after 4 h, yields of up to 94%).

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“…Mostly studied for their catalytic activity, NHC metal complexes have also exhibited Biological activity (anti-cancer, anti-bacterial, anti-fungal, etc) has also been reported for NHC complexes of other metals, e.g., Ni [54], Ru [55,56], Ag [57,58], Cu [59], Pd [60,61].…”

Section: Carbohydrate Nhc Complexes In Medicinal Chemistrymentioning

confidence: 99%

Carbohydrate– N -heterocyclic carbene metal complexes: Synthesis, catalysis and biological studies

Zhao

Ferro

Baker

2017

Coordination Chemistry Reviews

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Synthesis and anticancer properties of gold(I) and silver(I) N-heterocyclic carbene complexes

Cited by 108 publications

References 37 publications

Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

Ag(I) complexes of benzimidazol-2-ylidene ligands: a study of catalytic efficiency towards three-component coupling reactions

Carbohydrate– N -heterocyclic carbene metal complexes: Synthesis, catalysis and biological studies

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