Ag(I) complexes of benzimidazol-2-ylidene ligands: a study of catalytic efficiency towards three-component coupling reactions

Abstract

Abstract:The N -heterocyclic carbene (NHC)-Ag(I) complexes 3a-c were synthesized from benzimidazolium chlorides (2a-c = NHC.HCl), incorporating benzyl derivatives and a 2-methoxyethyl group (a: 3 N = 2,4,6-trimethylbenzyl; b:3 N = 2,3,5,6-tetramethylbenzyl; c: 3 N = pentamethylbenzyl). The compounds were characterized by spectroscopic and elemental analyses. The synthesized NHC-Ag(I) complexes (3a-c) were tested as catalysts for the catalytic threecomponent coupling reaction of aldehyde, alkyne, and amine to propargylamines in various solvents. All complexes were active catalysts for catalytic three-component coupling reactions with good yields under neat and mild conditions (after 4 h, yields of up to 94%).

Molecular docking and in vitro anticancer studies of silver(I)-N-heterocyclic carbene complexes

“…However, the C2 carbon of 2b , 2c , 2d, 2e, 2g, 2h, and 2i have not been observed in 13 C{ 1 H} NMR spectra. According to the literature [ 46 , 47 , 48 , 49 , 50 , 51 , 52 ], the fluxional behaviour of the Ag–NHC complexes may cause not to be observed the resonance of the C2 carbene carbon in the 13 C{ 1 H} NMR spectrum. However, based on these data, C2 carbon of 2a and 2f complexes was observed in 13 C{1H} NMR spectra; it can be said that fluxional movements are effective in 2b , 2c , 2d, 2e, 2g, 2h, and 2i complexes.…”