Synthesis, structural characterization of silver(I)-NHC complexes and their antimicrobial, antioxidant and antitumor activities

An Efficient, Three-Component Synthesis of Isoindolin-1-One-3-Phosphonates Under Mild and Solvent-Free Conditions and Their Biological Activities

“…Elemental microanalysis was performed on an ElementarVario El III Carlo Erba 1108 elemental analyzer, and the values found were within ± 0.3% of the theoretical values. Melting points were determined with Ko er bench at Isste of Borj cedria (Hammam Lif, University of Carthage, Borj Cedria, Tunisia) [46].…”

“…Finally, the crude product was puri ed by column chromatography. The crude product was analyzed by 1 H, 13 C and 31 P NMR spectroscopy [46]. maintained by passing in female BALB/c mice by injecting hind footpads with 1x10 6 .…”

Bioactivity and DNA/BSA Interactions of Selenium N‐Heterocyclic Carbene Adducts

“…[9] These metal complexes have very low permissible biological safety limits and considered generally toxic which calls for alternative biocomaptible complexes with similar level of activity. [9][10][11][12][13][14] Selenium is a biocompatible micronutrient that participates in various biological functions of skincare, antioxidant functions, detoxification of metals, free radical protection as well as the production of antibodies against cancer. Therefore, Organo-selenium (org-se) compounds are getting substantial attention due to their pronounced biological activities [15] and a number of research reports highlighting the antioxidant, antiinflammatory, anti-neurodegenerative and antimicrobial activity of org-Se compounds.…”

In Vitro Bioactivities of Isoindolin-1-3-Phosophonate Compounds

“…Elemental microanalysis was performed on an ElementarVario El III Carlo Erba 1108 elemental analyzer, and the values found were within ± 0.3% of the theoretical values. Melting points were determined with Ko er bench at Isste of Borj cedria (Hammam Lif, University of Carthage, Borj Cedria, Tunisia)[46].General procedure for the synthesis of Diethyl 3-oxoisoindolin-1-yl phosphonate compounds (4a-f) 2-Formylbenzoic acid (2.5 g, mmol), amine (18 mmol) and diethylphosphite (2.9 g, 21 mmol) were stirred at 80 °C for 1.0 h, and the progress of the reaction was monitored by TLC. The mixture was extracted with dichloromethane, dried with MgSO 4 , ltered and evaporated.…”

“…Finally, the crude product was puri ed by column chromatography. The crude product was analyzed by 1 H,13 C and 31 P NMR spectroscopy[46].Diethyl 2-(2,2-dimethoxyethyl)-3-oxoisoindolin-1-yl phosphonate (4a) Yield = 70%;oil; 1 H NMR (300 MHz, CDCl 3 ) δ(ppm): 1.02 (t, J = 7.1 Hz, 3H), 1.17 (t, J = 7.1 Hz, 3H), 3.27 (d, J = 9.6 Hz, 6H), 3.62-3.91 (m , 3H), 3.99-4.09 (m, 2H), 4.22 (dd, J = 4.0, 14.4 Hz, 1H), 4.50 (dd, J = 4.0, 6.5 Hz, 1H), 5.11 (d, J = 13.1 Hz, 1H), 7.39-7.52 (m, 2H), 7.70 (dd, J= 3.4, 7.6 Hz, 2H); 13 C NMR (75 MHz, CDCl 3 ) δ (ppm): 16.0 (d, J = 5.5 Hz, CH 3 ), 16.2 (d, J = 5.7 Hz, CH 3 ), 42.4 (CH 2 ), 53.5 (CH 3 ), 54.4 (CH 3 ), 57.0 (CH 2 ), 59.0 (CH 2 ) 63.05(CH 2 ),102.31(CH);123.59(CH);124.32(CH);128.56(CH);131.50(CH);131.69( C);139.03(C );168.80(C ); 31 P NMR (121 MHz, CDCl 3 ) δ (ppm):18.3. Anal.…”