Synthesis and antibacterial activity of colloidal selenium nanoparticles in chitosan solution: a new antibacterial agent

Rangrazi, Abdolrasoul; Bagheri, Hossein; Ghazvini, Kiarash; Boruziniat, Alireza; Darroudi, Majid

doi:10.1088/2053-1591/ab6a56

Cited by 32 publications

(18 citation statements)

References 34 publications

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“…Especially efficient were the chitosan-stabilized SeNPs, which is in agreement with observations that chitosan alone possesses potent activity against Gram-positive species (Goy et al, 2009 ). Recently, Rangrazi et al tested the antimicrobial activity of chitosan-stabilized SeNPs with a diameter range of 50–105 nm (Rangrazi et al, 2020 ). They documented MICs of 137 and 274 μg/mL against S. aureus and E. faecalis , respectively, but did not observe any activity against Gram-negative species.…”

Section: Resultsmentioning

confidence: 99%

Comparative Study of the Antimicrobial Activity of Selenium Nanoparticles With Different Surface Chemistry and Structure

Filipović

Ušjak

Milenković

et al. 2021

Front. Bioeng. Biotechnol.

130

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Although selenium nanoparticles (SeNPs) have gained attention in the scientific community mostly through investigation of their anticancer activity, a great potential of this nanomaterial was recognized recently regarding its antimicrobial activity. The particle form, size, and surface chemistry have been recognized as crucial parameters determining the interaction of nanomaterials with biological entities. Furthermore, considering a narrow boundary between beneficial and toxic effects for selenium per se, it is clear that investigations of biomedical applications of SeNPs are very demanding and must be done with great precautions. The goal of this work is to evaluate the effects of SeNPs surface chemistry and structure on antimicrobial activity against several common bacterial strains, including Staphylococcus aureus (ATCC 6538), Enterococcus faecalis (ATCC 29212), Bacillus subtilis (ATCC 6633), and Kocuria rhizophila (ATCC 9341), as well as Escherichia coli (ATCC 8739), Salmonella Abony (NCTC 6017), Klebsiella pneumoniae (NCIMB 9111) and Pseudomonas aeruginosa (ATCC 9027), and the standard yeast strain Candida albicans (ATCC 10231). Three types of SeNPs were synthesized by chemical reduction approach using different stabilizers and reducing agents: (i) bovine serum albumin (BSA) + ascorbic acid, (ii) chitosan + ascorbic acid, and (iii) with glucose. A thorough physicochemical characterization of the obtained SeNPs was performed to determine the effects of varying synthesis parameters on their morphology, size, structure, and surface chemistry. All SeNPs were amorphous, with spherical morphology and size in the range 70–300 nm. However, the SeNPs obtained under different synthesis conditions, i.e. by using different stabilizers as well as reducing agents, exhibited different antimicrobial activity as well as cytotoxicity which are crucial for their applications. In this paper, the antimicrobial screening of the selected systems is presented, which was determined by the broth microdilution method, and inhibitory influence on the production of monomicrobial and dual-species biofilm was evaluated. The potential mechanism of action of different systems is proposed. Additionally, the cytotoxicity of SeNPs was examined on the MRC-5 cell line, in the same concentration interval as for antimicrobial testing. It was shown that formulation SeNPs-BSA expressed a significantly lower cytotoxic effect than the other two formulations.

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Section: Resultsmentioning

confidence: 99%

Comparative Study of the Antimicrobial Activity of Selenium Nanoparticles With Different Surface Chemistry and Structure

Filipović

Ušjak

Milenković

et al. 2021

Front. Bioeng. Biotechnol.

130

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“…acidophilus, and C. albicans. Previous research [24] confirmed the significant antibacterial effects of a Cts-Se-NP solution against three gram-positive bacteria (Streptococcus sanguinis, Staphylococcus aureus, and Enterococcus faecalis), while no such effects were observed on gram-negative bacteria.…”

Section: Discussionmentioning

confidence: 78%

“…In this study, Cts-Se-NPs was synthesized according to our previous research [24]. Cts (0.15 g) was dissolved in a solution of 1.0% acetic acid solution at room temperature, 25 milliliters of ascorbic acid (0.01 g/ml-1) was added to the Cts solution, and the solution was stirred.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, we have investigated the antibacterial activity of colloidal selenium nanoparticles in chitosan solution (Cts-Se-NPs) as a new antibacterial agent [24], and the obtained results indicated that the Cts-Se-NP solution had excellent antibacterial activity against gram-positive bacteria (Streptococcus sanguinis, Staphylococcus aureus, and Enterococcus faecalis). In a continuation of our previous research, the present study aimed to investigate the antimicrobial activity of Cts-Se-NPs against S. mutans, L. acidophilus, and C. albicans.…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Activity of Colloidal Selenium Nanoparticles in Chitosan Solution against Streptococcus mutans, Lactobacillus acidophilus, and Candida albicans

Darroudi

Rangrazi

Ghazvini

et al. 2021

Pesqui. Bras. Odontopediatria Clín. Integr.

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Objective: To investigate the antimicrobial activity of colloidal selenium nanoparticles in chitosan solution (Cts-Se-NPs) against Streptococcus mutans, Lactobacillus acidophilus, and Candida albicans. Material and Methods: Cts-Se-NPs solution was prepared using a simple chemical reduction method. The MIC and MBC against S. mutans, L. acidophilus, and C. albicans were determined using the broth dilution assay. Results: The Cts-Se-NPs had remarkable antimicrobial activity against S. mutans, L. acidophilus, and C. albicans. The MIC values of the Cts-Se-NPs were lowest for S. mutans (0.068 mg/ml) compared to L. acidophilus (0.137 mg/ml), and C. albicans (0.274 mg/ml). The MBC values of the Cts-Se-NPs against the microorganisms after one, two, six, and 24 hours indicated that the concentration of 0.274 mg/ml of Cts-Se-NPs completely killed S. mutans, L. acidophilus, and C. albicans after one, two, and six hours, respectively. At the concentration of 0.137 mg/ml, S. mutans and L. acidophilus were killed after six and 24 hours, respectively. Conclusion: These findings encourage the potential use of Cts-Se-NPs in dentistry, while further clinical research is required in this area.

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“…Several metal nanoparticles (NPs), such as silver, zinc oxide (ZnO), titanium dioxide (TiO 2 ), and copper oxide (CuO) NPs, have been used for modification of orthodontic dental materials [ 12 , 13 , 14 , 15 ], although the use of biocompatible non-metal NPs is more preferable. In recent years, chitosan, as a natural, non-toxic, biocompatible, and biodegradable polysaccharide with remarkable antimicrobial properties [ 16 , 17 ], has been used in different areas of dentistry, such as modification of restorative dental materials, adhesion and dentin bonding, enamel repair, and modification of dentifrices [ 18 ]. Chitosan is a cationic material, as it contains one primary amine group.…”

Section: Introductionmentioning

confidence: 99%

Incorporation of Chitosan Nanoparticles into a Cold-Cure Orthodontic Acrylic Resin: Effects on Mechanical Properties

2021

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Improvement of the antibacterial properties of acrylic resins, used in the construction of removable orthodontic appliances, is an important strategy to reduce the incidence of caries and oral diseases in orthodontic treatments. The addition of antimicrobial agents to acrylic resins is one of the effective methods to enhance the antimicrobial properties of these materials. However, one main concern is that modification of acrylic resin has negative effects on its mechanical properties. Recently, chitosan nanoparticles (NPs), as biocompatible and biodegradable polysaccharides with remarkable antimicrobial properties, have been used in different areas of dentistry and medicine. This study aimed to investigate the effects of adding chitosan NPs on the mechanical properties of a cold-cure orthodontic acrylic resin. The chitosan NPs were added to the acrylic resin in various weight percentages: 0% (control), 0.5%, 1%, 2%, and 4%. The flexural strength, compressive strength, Vickers microhardness, and impact strength measurements were performed for all five groups. The results showed that adding up to 1% (w/w) chitosan NPs to an acrylic resin had no significant negative effects on its flexural strength and compressive strength, while it decreased these parameters at weight percentages of 2% and 4% (w/w). The results also revealed that modification of acrylic resin with chitosan NPs up to 4% had no significant negative effects on the microhardness and impact strength of acrylic resin. In conclusion, the addition of chitosan NPs up to 1% (w/w) had no significant negative effects on the mechanical properties of cold-cure acrylic resin.

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Synthesis and antibacterial activity of colloidal selenium nanoparticles in chitosan solution: a new antibacterial agent

Cited by 32 publications

References 34 publications

Comparative Study of the Antimicrobial Activity of Selenium Nanoparticles With Different Surface Chemistry and Structure

Comparative Study of the Antimicrobial Activity of Selenium Nanoparticles With Different Surface Chemistry and Structure

Antimicrobial Activity of Colloidal Selenium Nanoparticles in Chitosan Solution against Streptococcus mutans, Lactobacillus acidophilus, and Candida albicans

Incorporation of Chitosan Nanoparticles into a Cold-Cure Orthodontic Acrylic Resin: Effects on Mechanical Properties

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