Antimicrobial Activity of Colloidal Selenium Nanoparticles in Chitosan Solution against Streptococcus mutans, Lactobacillus acidophilus, and Candida albicans

Darroudi, Majid; Rangrazi, Abdolrasoul; Ghazvini, Kiarash; Bagheri, Hossein; Boruziniat, Alireza

doi:10.1590/pboci.2021.069

Cited by 7 publications

(6 citation statements)

References 36 publications

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“…The toxicity of SeNPs was assessed in various cell lines, revealing minimal or negligible toxicity towards normal cells, even at the same concentration range used for antimicrobial testing. Remarkably, SeNPs exhibited a robust antiproliferative effect on cancer cells [ 50 ]. The anticancer activity of SeNPs can be explained by their pro-oxidant property.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Selenium Nanoparticles (SeNPs) against Potentially Pathogenic Oral Microorganisms: A Scoping Review

Sans-Serramitjana,

Obreque,

Muñoz

et al. 2023

Pharmaceutics

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Biofilms are responsible for the most prevalent oral infections such as caries, periodontal disease, and pulp and periapical lesions, which affect the quality of life of people. Antibiotics have been widely used to treat these conditions as therapeutic and prophylactic compounds. However, due to the emergence of microbial resistance to antibiotics, there is an urgent need to develop and evaluate new antimicrobial agents. This scoping review offers an extensive and detailed synthesis of the potential role of selenium nanoparticles (SeNPs) in combating oral pathogens responsible for causing infectious diseases. A systematic search was conducted up until May 2022, encompassing the MEDLINE, Embase, Scopus, and Lilacs databases. We included studies focused on evaluating the antimicrobial efficacy of SeNPs on planktonic and biofilm forms and their side effects in in vitro studies. The selection process and data extraction were carried out by two researchers independently. A qualitative synthesis of the results was performed. A total of twenty-two articles were considered eligible for this scoping review. Most of the studies reported relevant antimicrobial efficacy against C. albicans, S. mutans, E. faecalis, and P. gingivalis, as well as effective antioxidant activity and limited toxicity. Further research is mandatory to critically assess the effectiveness of this alternative treatment in ex vivo and in vivo settings, with detailed information about SeNPs concentrations employed, their physicochemical properties, and the experimental conditions to provide enough evidence to address the construction and development of well-designed and safe protocols.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Selenium Nanoparticles (SeNPs) against Potentially Pathogenic Oral Microorganisms: A Scoping Review

Sans-Serramitjana,

Obreque,

Muñoz

et al. 2023

Pharmaceutics

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“…Additionally, this classification denotes that the S. mutans bacterial strain has the potential to operate as a moderate biofilm producer [27]. Several studies have previously reported on the MIC of SeNPs, which have concluded that the MIC against S. mutans could be as low as 68 µg/mL [41]. While these studies have reported commendable results at relatively low concentrations, MICs are only a representation of the activity of a drug against bacteria.…”

Section: Effect Of Size and Concentration On Antibiofilm Activity Of ...mentioning

confidence: 99%

Selenium Nanoparticle Activity against S. mutans Biofilms as a Potential Treatment Alternative for Periodontitis

Hamman,

Ramburrun,

Dube

2024

Pharmaceutics

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The disruption of periodontal biofilms and prevailing antimicrobial resistance issues continue to pose a great challenge to the treatment of periodontitis. Here, we report on selenium nanoparticles (SeNPs) as a treatment alternative for periodontitis by determining their antibiofilm activity against S. mutans biofilms and the potential role of particle size in disrupting biofilms. SeNPs were synthesised via a reduction reaction. Various physicochemical characterisations were conducted on the NPs, including size and shape. The microbroth dilution method was used to conduct the biofilm and antibiofilm assay against S. mutans, which was analysed by absorbance. SeNPs displayed hydrodynamic sizes as low as 46 ± 4 nm at a volume ratio of 1:5 (sodium selenite/ascorbic acid) with good monodispersity and stability. Hydrodynamic sizes of SeNPs after resuspension in tryptic soy broth supplemented with 2.5% sucrose (TSB + 2.5% suc.) and incubated at 37 °C for 24 h, ranged from 112 to 263 nm, while the zeta potential values increased to greater than −11 mV. The biofilm assay indicated that S. mutans are weakly adherent, bordering on moderately adherent biofilm producers. The minimum biofilm inhibitory concentration (MBIC) was identified at 500 µg/mL. At a 1000 µg/mL concentration, SeNPs were able to inhibit S. mutan biofilms up to 99.87 ± 2.41% at a volume ratio of 1:1. No correlation was found between antibiofilm activity and particle size; however, antibiofilm activity was proven to be concentration-dependant. SeNPs demonstrate antibiofilm activity and may be useful for further development in treating periodontitis.

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“…Denture use may change the oral environment and provide a suitable condition for the proliferation and colonization of microorganisms [1,2]. For example, C. albicans, as a commensal fungus that colonizes the human mucosal surfaces in the oral cavity, is present in 30-60% of healthy individuals and 60-100% of denture wearers [3].…”

Section: Introductionmentioning

confidence: 99%

Effect of Ozonated Water on the Color Stability of Denture Teeth and Heat Polymerized Acrylic Base Resin

Mirmortazavi

Chamani

Bagheri

et al. 2023

Pesqui. Bras. Odontopediatria Clín. Integr.

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Objective: To determine the effect of ozonated water on the color stability of denture tooth and denture bases. Material and Methods: Thirty denture base discs consisting of 15 Acropars and 15 ProBase Hot specimens with the dimensions of 40 × 5 mm were prepared. Fifteen denture teeth in shade A1 (Ivoclar Vivadent, Schaan, Liechtenstein) were mounted in a specific acrylic jig. All specimens were immersed in three solutions (1% sodium hypochlorite, ozonated water, and distilled water) for four months (one year of clinical use). Color measurements were done with a spectrophotometer and assessed using the CIE L*a*b* colorimetric system (0, 4, 8, 12, and 16 weeks). Data were analyzed using the three-way ANOVA and Tukey test (α=0.05). Results: Tukey's post hoc test revealed a significant change in color in the Acropars denture base for the distilled water group compared to the ozonated water and 1% hypochlorite (p<0.05). Regarding the ProBase Hot denture base, significantly less color change was observed in the 1% hypochlorite group compared to the ozonated water and distilled water (p≤0.001). For the denture teeth, significantly less color change was seen in the distilled water group than in the ozonated water (p=0.015) and 1% hypochlorite (p<0.05) groups. Conclusion: The color change of denture bases and denture tooth in ozonated water are acceptable. Ozonated water can be considered a good disinfectant for cleaning dentures.

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Antimicrobial Activity of Colloidal Selenium Nanoparticles in Chitosan Solution against Streptococcus mutans, Lactobacillus acidophilus, and Candida albicans

Cited by 7 publications

References 36 publications

Antimicrobial Activity of Selenium Nanoparticles (SeNPs) against Potentially Pathogenic Oral Microorganisms: A Scoping Review

Antimicrobial Activity of Selenium Nanoparticles (SeNPs) against Potentially Pathogenic Oral Microorganisms: A Scoping Review

Selenium Nanoparticle Activity against S. mutans Biofilms as a Potential Treatment Alternative for Periodontitis

Effect of Ozonated Water on the Color Stability of Denture Teeth and Heat Polymerized Acrylic Base Resin

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