Synthesis and antibacterial activity of some novel bis-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and bis-4-thiazolidinone derivatives from terephthalic dihydrazide

Synthesis of Novel [1,2,4]triazolo[3,4-B][1,3,4]thiadiazole-6(5h)-Thione, 5,8-Dihydro-[1,2,4] Triazolo[4,3-B][1,2,4,5]tetrazine and 5,10-Dihydro -[1,2,4]triazolo[4,3-B][1,2,4] Benzotriazine Derivatives and Study Their Biological Activity.

“…For this reason, much attention has been directed in our laboratory for synthesis of new compounds containing [1,2,4]triazole nucleus fused with a different substituted [1,3,4] thiadiazole, [1,2,4,5]tetrazine and [1,2,4] triazine moieties, in order to study their anticancer activity.…”

“…The chemistry of 1,2,4-triazoles and their fused heterocyclic derivatives have received considerable attention owing to their synthetic and effective biological importance. For example, a large number of 1,2,4-triazoles have been incorporated into a wide variety of therapeutically interesting drug candidates possessing antimicrobial [1][2][3][4][5], anti-inflammatory [6], analgesic [7] and anticancer activities [8,9]. Among these heterocycles, the mercapto and thione substituted 1,2,4-triazole ring systems have been well studied and so far a variety of biological activities have been reported for a large number of their derivatives [10,11].…”

Synthesis and <i>In Vitro </i> Antimicrobial Activity of 3-(5-((2-Oxo-2<i>H</i>-Chromen-4-yl)Thio)-4-Phenyl-Thiazol-2-yl)-2-Substitutedphenyl Thiazolidin-4-One

“…Thiazolidine-4-ones and it derivatives possess some important biological activities and pharmacological properties such as anti-inflammatory [4], antitubercular [5], anticancer [6,7], antitumor [8], anti-HIV [9], antibacterial [10], antifungal [11], antioxidant [12], antiviral [13], anticonvulsant [14], nematicidal [15], antihistaminic [16], anti YFV (yellow fever virus) [17] activity etc.…”

Synthesis and In-vitro Activity of Some New Class of Thiazolidinone and Their Arylidene Derivatives

“…Since the discovery of heterocyclic nucleus the chemistry of thiazolidinones and their allied compounds continue to draw attention of organic chemists due to their various biological activities such as antibacterial, [1][2][3][4] anticancer, 5 antitubercular, 6,7 antifungal, 8 anti-inflammatory, 9 antiviral, 10 analgesic. 11 Thiazolidinone and their arylidene derivatives are also having highly therapeutic nature such as antioxidants, 12 antitumor agents, 13 agricultural fungicides.…”