Synthesis, analgesic, anti-inflammatory, and antimicrobial activity of some novel pyrimido[4,5-b]quinolin-4-ones

Synthesis and evaluation of analgesic, anti-inflammatory and ulcerogenic activities of some triazolo- and 2-pyrazolyl-pyrido[2,3-d]-pyrimidines

“…1 H NMR (Table II) and 13 C NMR spectra (Table III) were recorded on JEOL EX-270 and JEOL ECA-500 (Jeol, Japan) and chemical shifts were expressed as d values against Si(CH 3 ) 4 as internal standard. IR spectra were recorded as KBr pellets on a Perkin-Elmer 1430 spectrometer (USA).…”

“…New series of 2-hydrazino-7,8-dihydro-6H-cyclopenta [5,6] pyrido [2,3-d]pyrimidines and its 1,7,8,9-tetrahydrocyclopenta [5,6]pyrido [2,3-d] [1,2,4]triazolo [4,3-a]pyrimidine, 1,7, 8,9-tetrahydrocyclopenta [5,6]pyrido [2,3-d] [1,2,3,4]tetrazolo [4,5-a]pyrimidine, 8,9-dihydro-7H-cyclopenta [5,6]pyrido [2,3-d]imidazolo [1,2-a]pyrimidine, 2-(pyrazol-1-yl)-7,8--dihydro-6H-cyclopenta [5,6]pyrido [2,3-d]pyrimidine derivatives were prepared in order to obtain new compounds with potential anti-inflammatory and analgesic activity and low ulcerogenic effect. The compounds possessing potent anti-inflammatory activity were further tested for their analgesic and ulcerogenic activities.…”

“…The compounds possessing potent anti-inflammatory activity were further tested for their analgesic and ulcerogenic activities. Compounds 3-amino--6-(4-aryl)-9-(4-arylmethylene)-cyclopenta [5,6]pyrido [2,3 - [5,6] -pyrido [2,3-d]pyrimidin-4(H)-one (10a) and 3-thioxo-6-(4--aryl)-9-(4-arylmethylene)-cyclopenta [5,6]pyrido [2,3-d]- [1,2,4]triazolo [4,3-a]pyrimidin-5(H)-one (13) showed significant analgesic effects. Compound 2-(3-amino-5-hydroxypyrazol-1-yl)-5-(4-aryl)-8-(4-arylmethylene)-cyclopenta [5,6]pyrido [2,3-d]pyrimidin-4(H)-one (10a) was evaluated as the lead compound having higher anti-inflammatory activity (82.8%) than ibuprofen (79.5%) and lower ulcerogenic effect.…”

“…Keywords: pyrido [2,3-d]pyrimidines, [1,2,4]triazole anellation, anti-inflammatory, analgesic activity xic (1). Also, pyrido [2,3-d]pyrimidin-7(8H)-ones have attracted interest of pharmaceutical companies due to the wide range of biological activities associated with this scaffold.…”

Synthesis and reactions of 3-hydrazino-2,3,4,7,8,9-hexahydro-1H-benzo[6',7']cyclohepta[1',2':4,5]pyrido[2,3-d]pyrimidin-1-one

“…5 Substituted hydrazones are known as one of the most important classes of organic compounds, having analgesic, anticancer, antitumor, anti-inflammatory, antibacterial, and antifungal activities. [6][7][8][9][10][11] In addition, many of the poly-heterocyclic ring systems have several biological activities. 12,13 In continuation of our efforts on the synthesis of new poly-heterocyclic compounds, 14,15 and based on the above observations, we report in this context a simple method for preparation of hydrazones of a tetraheterocyclic ring system.…”