Syntheses, Spectral Characterization, and Antimicrobial Studies on the Coordination Compounds of Metal Ions with Schiff Base Containing Both Aliphatic and Aromatic Hydrazide Moieties

Kumar, Dinesh; Chadda, Silky; Sharma, Jyoti; Surain, Parveen

doi:10.1155/2013/981764

Cited by 28 publications

(22 citation statements)

References 37 publications

(23 reference statements)

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“…C 36 showed MIC valu of 128 μg/mL. It may be concluded that acitvity of C 36 is due to presence of Mn ion since L 36 was found totally inactive against these organisms under the same experimental conditions …”

Section: Mn–complexes With Tridentate Ligandsmentioning

confidence: 99%

Coordination Complexes of Manganese and Their Biomedical Applications

Ali

Iqbal

2017

ChemistrySelect

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The clinical success of metallodrugs is rapidly increasing. The historical use of cisplatin and recently a successful marketing of its clinically advanced derivatives (oxaliplatin, carboplatin, nedaplatin, lobaplatin and heptaplatin) for the treatment of various types of cancer has opened new horizons for metal based drugs. Complexes of cobalt, gold, ruthenium, palladium, manganese and even arsenic are either being marketed or close to get success in clinical trials for the treatment of various diseases. Current review compiles the advances on manganese complexes and their biomedical applications. A possible structure activity relationship has been discussed.

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Section: Mn–complexes With Tridentate Ligandsmentioning

confidence: 99%

Coordination Complexes of Manganese and Their Biomedical Applications

Ali

Iqbal

2017

ChemistrySelect

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“…The NH2 group is not participating in coordination 34. New bands observed at 538-585 cm -1 and at 595-623 cm -1 which could be attributed to υ(M-O) and υ(M-N) vibrations [35,36].…”

Section: Ir Spectramentioning

confidence: 94%

Synthesis, Characterization and Antibacterial Activity Studies of Some Transition Metal Chelates of Mn(II), Ni(II) and Cu(II) with Schiff Base Derived from Diacetylmonoxime with O-phenylenediamine

et al. 2020

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In this study, the transition metal chelates of Mn(II), Ni(II) and Cu(II) with Schiff base were synthesized and characterized. The elemental analysis data showed that, the isolated chelates are in 1:1 [M:L] ratio. The molar conductance values revealed that the chelates are none electrolyte in nature. The results of magnetic moment measurements demonstrated that, the chelates of Mn(II) and Cu(II) have unpaired electrons and chelates of Ni(II) is diamagnetic. The infrared spectral data displayed the main coordination sites of (2E, 3E)-3-((2-aminophenyl)imino)butan-2-one oxime towards Mn(II), Ni(II) and Cu(II) ions. The electronic spectrum results of the Schiff base ligand and its chelates suggest that the Mn(II) and Cu(II) chelates have octahedral structure and Ni(II) chelate is square planar. Schiff base Chelates (2E, 3E)-3-((2-amino phenyl) imino) butane-2one oxime

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“…Relevant infrared spectral bands of the synthesized compounds were tentatively assigned by comparison with literature reports on similar compounds of related functional groups (Kumar et al, 2013). The medium band at 3,539 cm −1 in the HL spectrum was apportioned to the stretching vibration of a secondary amine group, N-H (Halli et al, 2004).…”

Section: Ftir Spectra Studiesmentioning

confidence: 95%

Heteroleptic Metal Complexes of a Pyrimidinyl Based Schiff Base Ligand Incorporating 2,2′-Bipyridine Moiety: Synthesis, Characterization, and Biological Studies

2019

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A sequence of transition metal complexes of Mn(II), Co(II), Ni(II), and Cu(II) incorporating a novel pyrimidinyl based Schiff base ligand, 2-(4,6-dimethylpyrimidin-2-ylamino)naphthalene-1,4-dione (HL) and 2,2 ′-bipyridine has been synthesized and characterized using elemental, magnetic, conductance, infrared (FT-IR), nuclear magnetic resonance (1 Hand 13 C-NMR), electronic (UV-Vis), electrospray ionization mass spectrometry (ESI-MS), thermographic analysis (TGA), and molecular docking studies. The acquired results were consistent with the adoption of the chemical formula, [M(X)(L)(Y)]•nH 2 O (where M = Mn, Co, Ni, and Cu; L = Schiff base; X = 2,2 ′-bipy; Y = OAc; and n = 0,1) for the metallic complexes. HL ligand acts as a bidentate chelator and coordinates to metallic ion centre through carbonyl oxygen atom and deprotonated imide nitrogen. Similarly, 2,2 ′-bipy acts as a non-ionic bidentate chelator coordinating to metallic ion center via two nitrogen atoms. The mixed ligand complexes were appraised against pathogenic strains: S. aureus, P. aeruginosa, E. coli, B. cereus, P. mirabilis, K. oxytoca, A. niger, A. flevus, and R. Stolonifer. The antimicrobial studies gave moderate-good activity. Molecular docking studies on these compounds were done to indicate binding interactions between the compounds and adopted drug targets. Additionally, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of the compounds were determined at different concentrations. The antioxidant study showed good radical scavenging abilities.

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Syntheses, Spectral Characterization, and Antimicrobial Studies on the Coordination Compounds of Metal Ions with Schiff Base Containing Both Aliphatic and Aromatic Hydrazide Moieties

Cited by 28 publications

References 37 publications

Coordination Complexes of Manganese and Their Biomedical Applications

Coordination Complexes of Manganese and Their Biomedical Applications

Synthesis, Characterization and Antibacterial Activity Studies of Some Transition Metal Chelates of Mn(II), Ni(II) and Cu(II) with Schiff Base Derived from Diacetylmonoxime with O-phenylenediamine

Heteroleptic Metal Complexes of a Pyrimidinyl Based Schiff Base Ligand Incorporating 2,2′-Bipyridine Moiety: Synthesis, Characterization, and Biological Studies

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