Syntheses of biodegradable vinyl polymers by insertion of N-benzyl-4-vinylpyridinium chloride into the main chain

Kawabata, Nariyoshi

doi:10.1016/j.reactfunctpolym.2007.06.015

Cited by 7 publications

(2 citation statements)

References 39 publications

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“…Several innovative studies have attempted to endow PP with antibacterial and antiviral properties through surface treatment. In particular, numerous macromolecules with antimicrobial and antiviral activities have been developed owing to the dramatic progress in synthetic polymer chemistry. − Regarding studies aimed at the immobilization of chemical agents on the PP surfaces, the discovery that soluble poly(vinylpyridinium halides) and poly( N -benzyl-4-vinylpyridinium salts) cross-linked to resin particles exhibit antibacterial activity has opened the possibility of binding antimicrobial molecules to polymer surfaces. − Subsequently, the binding of such molecules to polyolefin surfaces was successfully achieved by forming a thin silica layer via combustion chemical vapor deposition followed by treatment with a silane coupling agent, acroylation, and copolymerization with vinylpyridine. , A simpler approach has also been reported, namely, the synthesis of antimicrobial copolymers of hydrophobic N -alkyl- and benzophenone-containing poly(ethylenimine) from linear poly(2-ethyl-2-oxazoline) and the binding of this polymer to the PP surface via photo-cross-linking . These materials showed sufficient antimicrobial activity against Gram-positive and Gram-negative bacteria but were not tested against viruses at the time of their development.…”

Section: Introductionmentioning

confidence: 99%

“… 39 − 41 Regarding studies aimed at the immobilization of chemical agents on the PP surfaces, the discovery that soluble poly(vinylpyridinium halides) and poly( N -benzyl-4-vinylpyridinium salts) cross-linked to resin particles exhibit antibacterial activity has opened the possibility of binding antimicrobial molecules to polymer surfaces. 42 − 44 Subsequently, the binding of such molecules to polyolefin surfaces was successfully achieved by forming a thin silica layer via combustion chemical vapor deposition followed by treatment with a silane coupling agent, acroylation, and copolymerization with vinylpyridine. 45 , 46 A simpler approach has also been reported, namely, the synthesis of antimicrobial copolymers of hydrophobic N -alkyl- and benzophenone-containing poly(ethylenimine) from linear poly(2-ethyl-2-oxazoline) and the binding of this polymer to the PP surface via photo-cross-linking.…”

Section: Introductionmentioning

confidence: 99%

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Polypropylene-Rendered Antiviral by Three-Dimensionally Surface-Grafted Poly(N-benzyl-4-vinylpyridinium bromide)

Hirao,

Takeuchi,

Kawada

et al. 2024

ACS Appl. Mater. Interfaces

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To inhibit viral infection, it is necessary for the surface of polypropylene (PP), a polymer of significant industrial relevance, to possess biocidal properties. However, due to its low surface energy, PP weakly interacts with other organic molecules. The biocidal effects of quaternary ammonium compounds (QACs) have inspired the development of nonwoven PP fibers with surface-bound quaternary ammonium (QA). Despite this advancement, there is limited knowledge regarding the durability of these coatings against scratching and abrasion. It is hypothesized that the durability could be improved if the thickness of the coating layer were controlled and increased. We herein functionalized PP with three-dimensionally surface-grafted poly(N-benzyl-4-vinylpyridinium bromide) (PBVP) by a simple and rapid method involving graft polymerization and benzylation and examined the influence of different factors on the antiviral effect of the resulting plastic by using a plaque assay. The thickness of the PBVP coating, surface roughness, and amount of QACs, which jointly determine biocidal activity, could be controlled by adjusting the duration and intensity of the ultraviolet irradiation used for grafting. The best-performing sample reduced the viral infection titer of an enveloped model virus (bacteriophage ϕ6) by approximately 5 orders of magnitude after 60 min of contact and retained its antiviral activity after surface polishing-simulated scratching and abrasion, which indicated the localization of QACs across the coating interior. Our method may expand the scope of application to resin plates as well as fibers of PP. Given that the developed approach is not limited to PP and may be applied to other low-surface-energy olefinic polymers such as polyethylene and polybutene, our work paves the way for the fabrication of a wide range of biocidal surfaces for use in diverse environments, helping to prevent viral infection.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polypropylene-Rendered Antiviral by Three-Dimensionally Surface-Grafted Poly(N-benzyl-4-vinylpyridinium bromide)

Hirao,

Takeuchi,

Kawada

et al. 2024

ACS Appl. Mater. Interfaces

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Sanitizing agents for virus inactivation and disinfection

Lin

Lim

Ke-min

et al. 2020

VIEW

203

217

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Viral epidemics develop from the emergence of new variants of infectious viruses. The lack of effective antiviral treatments for the new viral infections coupled with rapid community spread of the infection often result in major human and financial loss. Viral transmissions can occur via close human‐to‐human contact or via contacting a contaminated surface. Thus, careful disinfection or sanitization is essential to curtail viral spread. A myriad of disinfectants/sanitizing agents/biocidal agents are available that can inactivate viruses, but their effectiveness is dependent upon many factors such as concentration of agent, reaction time, temperature, and organic load. In this work, we review common commercially available disinfectants agents available on the market and evaluate their effectiveness under various application conditions. In addition, this work also seeks to debunk common myths about viral inactivation and highlight new exciting advances in the development of potential sanitizing agents.

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