Syntheses, characterizations and crystal structures of new triorganotin complexes with 2‐mercaptopyrimidine and 4‐amino‐2‐mercaptopyrimidine

Abstract

Four triorganotin(IV) complexes with 2-mercaptopyrimidine (HSpym) and 4-amino-2-mercaptopyrimidine (HSapym

Syntheses, characterizations and crystal structures of triorganotin(IV) derivatives with 2-mercapto-4-quinazolinone

“…This may attribute that there is an intramolecular Sn-N weak interaction between Sn1 and N1 atoms. The Sn1-N1 bond length (3.048(9) Å ) is midway between the sums of the van der waals and covalent radii of tin and nitrogen (2.15, 3.74 Å ) [22], which is longer than that of complex Ph 3 Sn(Spym) (2.878 Å ) [5] but shorter than that reported in complex Ph 3 Sn(MBZ) (3.07 Å ) and Ph 3 Sn(MNBT) (3.14 Å ) [23,24]. The Sn1-S1 bond length (2.450 (3) Å ) is within the range reported for organotin(IV) complexes (2.41-2.48 Å ) [25][26][27] and is similar to that reported for the complex Ph 3 Sn(MNBT) (2.453 Å ) [24] and shorter than that of the complex Ph 3 Sn(MTS) (2.47 Å ) [28].…”

“…The geometry at Sn in complex 2 is also a distorted tetrahedral with the C-Sn-C angles ranging from 106.0(3)°to 115.7(3)°and C-Sn-S angles ranging from 100.1(3)°to 111.0(2)°, which is similar to that found in complex 1. The bond length of Sn1-S1 (2.4552 (17) Å ) approaches to the sum of the covalent radii of tin and sulfur (2.42 Å ) [29] and is shorter than that of complex Me 3 Sn(Spym) (2.463 Å ) [5]. While the bond distance of Sn1-N1 (3.043 (5) Å ) is slightly shorter that the corresponding distance in complex 1 (3.048 Å ) but longer than that of complex Me 3 Sn(Spym) (2.965 Å ) [5].…”

“…Besides the consideration mentioned above, as a part of our studies on the coordination of organotin(IV) moieties with thiol sulfur and heterocyclic nitrogen [3,5,18], we choose the unsymmetrical ligand 2-mercapto-4-quinazolinone (HSqualone) which shows potential multidentate coordinate possibilities owing to the existence of a deprotonated thiol and more than one coordinative active heterocyclic nitrogen atom along with a hydroxyl oxygen atom, there exist four coordination modes (Scheme 1). To learn the nature of its versatile coordination chemistry, we have defined the reaction in 1:1 molar ratio (R 3 SnCl:HSqualone), and obtained six triorganotin(IV) derivatives.…”

“…Especially many varieties of organotin(IV) complexes have been synthesized and studied in the context of their antitumour potential [5,6]. It has been proved that 2-mercapto-4-quinazolinone (HSqualone) derivatives are one kind of the most potent PARP (poly(ADP-ribose) polymerase) inhibitors evaluated recently to avoid the lack of ATP and NAD causing mitochondrial dysfunction and cell damage [7][8][9].…”

Biologically active 2-thione-4,6-diamino-5-hydroxypyrimidine transition metal complexes

“…The coordination chemistry of 4-amino-2-thiopyrimidine has been explored with a number of transition metals [9][10][11][12][13]. In addition, substituted 2-thiopyrimidines have an N-C-S moiety that offers the possibility of forming homo-or hetero-binuclear complexes [14].…”