Biologically active 2-thione-4,6-diamino-5-hydroxypyrimidine transition metal complexes

Abstract

New complexes of 2-thione-4,6-diamino-5-hydroxypyrimidine (HTDAHP) with Fe(III), Ni(II), Ag(I) and Ru (II) are described. IR, 1 H-NMR and mass spectra, conductivity, magnetic and thermal measurements of the complexes are reported and their structures discussed. HTDAHP behaves as a bidentate ligand, forming five membered hydroxyl-amino chelates or four-membered cyclic nitrogen-sulphur chelates without any participation of the pendant amino or hydroxy groups in complexation. The biological activities of the Ag(I) complexes against fungi (Aspergillus niger and Candida albicans) and bacteria (Staphylococcus aureus and Pseudomonas aeruginosa) have been investigated.

Synthesis, characterization and anticancer activity of 3-aminopyrazine-2-carboxylic acid transition metal complexes

“…The strong band near 1606 cm -1 assigned to d(NH 2 ) in Hapc is shifted to ca. 1618 cm -1 upon complexation [4,5]. The Raman and IR data suggest N, O mononegative bidentate coordination of (apc -) except for complexes (12) and (16).…”

“…We have previously reported the chemistry and anticancer activity of some transition metal complexes of 4,6-diamino-5-hydroxy-2-mercaptopyrimidine [4][5][6] and 5,6-diamino-2,4-dihydroxypyrimidine [7]. Pyrazines and its derivatives form an important class of compounds present in many natural flavours and complicated organic molecules [8].…”

“…Magnetic moments at 25°C were recorded using a Johnson Matthey magnetic susceptibility balance with Hg[Co(SCN) 4 ] as calibrant. IR spectra were measured as KBr discs on a Matson 5000 FT-IR spectrometer.…”

Composites of Bacterial Cellulose and Small Molecule-Decorated Gold Nanoparticles for Treating Gram-Negative Bacteria-Infected Wounds

“…Gold nanoparticles (Au‐NPs), due to their unique properties including low‐toxicity, photothermal effects, large specific surface area, versatility in surface modification, and polyvalent effects, are useful in developing therapeutic strategies . 4,6‐diamino‐2‐pyrimidinethiol (DAPT) has no obvious pharmaceutical effect; however, DAPT‐decorated Au‐NPs can fight against most of MDR Gram‐negative bacteria such as MDR Escherichia coli ( E. coli ) and MDR Pseudomonas aeruginosa ( P. aeruginosa ) via inhibiting energy metabolism and dissipating membrane of the bacteria …”

Ruthenium (II) complexes containing 2-mercaptothiazolinates as ligands and evaluation of their antimicrobial activity

“…Among the thioamides, the N-heterocyclic thiones can be highlighted as ligands in coordination chemistry due to their potential as metallodrugs [22,23]. As a consequence, several pyridine-2-thiones [24], pyrimidine-2-thiones [3,12,[25][26][27] or thiouracils [28][29][30][31][32] containing transition metal complexes have been isolated and their biological activity assayed.…”