Synthesis, characterization and anticancer activity of 3-aminopyrazine-2-carboxylic acid transition metal complexes

Abstract

Synthetic procedures are described that allow access to the new complexes cis-[Mo 2 O 5 (apc) 2 ], cis-[WO 2 (apc) 2 ], trans-[UO 2 (apc) 2 ], [Ru(apc) 2 (H 2 O) 2 ], [Ru(PPh 3 ) 2 (apc) 2 ], [Rh(apc) 3 ], [Rh(PPh 3 ) 2 (apc) 2 ]ClO 4 , [M(apc) 2 ], [M(PPh 3 ) 2 (apc)]Cl, [M(bpy)(apc)]Cl (M(II) = Pd, Pt), [Pd(bpy)(apc)Cl], [Ag(apc)(H 2 O) 2 ] and [Ir(bpy)-(Hapc) 2 ]Cl 3 , where Hapc, is 3-aminopyrazine-2-carboxylic acid. These complexes were characterized by physicochemical and spectroscopic techniques. Both Hapc and several of its complexes display significant anticancer activity against Ehrlich ascites tumour cells (EAC) in albino mice.

Synthesis, characterization and anticancer activity of 3-formylchromone benzoylhydrazone metal complexes

“…The weight loss observed below 130°C is apparently due to dehydration as the colors changed from pale to dark [45]. The thermogram of Hfcbh shows only one decomposition step indicating complete decomposition of the ligand (Found 99.6 %) [46].…”

Synthesis and Characterization of New Transition Metal Complexes of Schiff-base Derived from 2-Aminopyrimidine and 2,4-Dihydroxybenzaldehyde and Its Applications in Corrosion Inhibition

“…34 The electronic spectrum of the diamagnetic [Rh(Hapdhba)2 Cl(H2O)] complex displays bands at 590, 500 and 393 nm which resemble those of other six-coordinate Rh(III) complexes and may assign to -dπ)) nm. 26,35 This feature is attributed to a low-spin octahedral geometry around Ru(II). Similar spectral data are reported for [Ru (YPh3)2(Hcdhp)2] (Y = P, As, Hcdhp = 5-chloro-3-hydroxy-2-pyridinone)complexes 35 and [Ru(PPh3)2(apc)2] (ap = 3-aminopyrazine-2-carboxylic acid).…”

“…The appearance of two stretching bands is indicative of the cis configuration. 26 The strong IR band at 745 cm -1 is assigned to the νas (Mo-O-Mo) mode indicating the presence of a µ-O 2-group. 26 The IR spectrum of [UO2 (Hapdhba)2] exhibits only one U=O stretching band, i.e.…”

“…26 The strong IR band at 745 cm -1 is assigned to the νas (Mo-O-Mo) mode indicating the presence of a µ-O 2-group. 26 The IR spectrum of [UO2 (Hapdhba)2] exhibits only one U=O stretching band, i.e. νas (UO 2 ), at 925 cm -1 indicating its linear trans-dioxo configuration.…”

“…Similar spectral data are reported for [Ru (YPh3)2(Hcdhp)2] (Y = P, As, Hcdhp = 5-chloro-3-hydroxy-2-pyridinone)complexes 35 and [Ru(PPh3)2(apc)2] (ap = 3-aminopyrazine-2-carboxylic acid). 26 In the electronic spectrum of [Mo2O5(Hapdhba)2], 2+ displays bands at 450 and 360 (shoulder) nm, the later band is assigned to O 2-→ Mo VI (p-d transition) and is characteristic of the MoO2 2+ moiety in octahedral geometry. 5 The electronic spectrum of trans-[UO2(Hapdhba)2] shows two bands at 463 and 410 nm may be due to Σg 1+ → 2 πu and n → π* charge transfer, respectively.…”