Syntheses and reactions of methyl [3-(4-phenyl-thiazol-2-yl)-thioureido] alkanoates and related compounds

Abstract

Thiazole thioureas 4a-d and 6 bearing an amino acid ester residue were prepared by a one-pot sequential reaction of methyl thiocarbamate 2 with amino acid methyl ester hydrochlorides. Some chemoselective reactions of 4a,b with alkyl halides were studied.

Convenient Method for Synthesis of New Derivatives of (1-(4-(2,4-dichlorophenyl)-2-((4-nitrobenzylidene) amino)thiazol-5-yl)ethan-1-one

“…In 2amino thiazole the terminal amino group is responsible for the formation of Schiff base as thiazole derivatives. Important biological properties of Schiff base fascinated to different scientist and research scholar, as it shows antibacterial [3,4], antifungul [5], antimicrobial [6], anticonvulsant activity [7], anticancer [8][9][10], antitumor [11], antituberculosis [12], anti HIV-1 [13,14] anti-inflammatory agents [15], insecticidal [16] and antiviral agent [17]. The Schiff bases have wide range of application in pharmaceutical preaparation [18,19].…”