Convenient Method for Synthesis of New Derivatives of (1-(4-(2,4-dichlorophenyl)-2-((4-nitrobenzylidene) amino)thiazol-5-yl)ethan-1-one

Abstract

The new derivatives of thiazole based Schiff base of (1-(5-(2,3,4-trisubstitutedphenyl)-2-((4-nitrobenzylidene)amino)thiazol-4-yl)ethan-1-one (6) were synthesized by the treatment of 1-(2-amino-5-(2,3,4-trisubstitutedphenyl)thiazol-4-yl)ethan-1-one (4) and corresponding substituted benzaldehyde (5) in low cost easily available non flammable stable and ecofriendly solvent Polyethylene glycol-400 solvent medium. The reactions were performed in the good yield and less time. The structures of all synthesized compounds were established on the basis of elemental analysis, IR, NMR and Mass spectral data.