Synoviorthesis with radioactive Yttrium in haemophilia: Israel experience

Heim, Michael; Goshen, Elinor; Amit, Yehuda; Martinowitz, Uri

doi:10.1046/j.1365-2516.2001.00108.x

Cited by 52 publications

(63 citation statements)

References 18 publications

(15 reference statements)

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“…Duration of improvement pattern is not the same in different individuals, and in some patients the considerable initial drop in bleeding rate changes, and increases over the years [13,20]. The observations in this study also show that the percentage of cases with no bleeding episode after 32 P injection tends to decrease, especially during the early 6‐month postinjection (39% at third month to 26% at sixth month).…”

Section: Discussionmentioning

confidence: 64%

³²P colloid radiosynovectomy in treatment of chronic haemophilic synovitis: Iran experience

et al. 2007

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Repeated intra-articular bleeding with subsequent development of chronic synovitis and cartilage changes, leading to haemophilic arthropathy, is one the most debilitating problems in haemophilic patients. Radiosynovectomy is a familiar therapeutic choice in management of chronic synovitis in haemophilia. We report the treatments results of synoviorthesis with (32)P chromic phosphate with emphasis on clinical aspects. Between 2002 and 2006 we performed 66 procedures in 53 patients. Seven patients were excluded. The remaining 46 patients were followed for an average of 31 months. The mean age of patients at the time of injection was 15.9 years (range: 6-28). There were three repeat injections. According to Fernandez-pallazi and Cavilgia clinical classification (Table 1) [23], nine joints were Stage II and 46 were Stage III. In latest follow-up, 77% of patients reported at least a 50% decrease in bleeding frequency after treatment (P < 0.0001). The need for antihaemophilic factor consumption dropped by about 74% postradiosynovectomy (P < 0.0001). In most of the injected joints, the range of motion remained stable or improved. A trend was found for the number of haemarthrosis to increase after a period of considerable improvement. Synoviorthesis using (32)P effectively reduces the intra-articular bleeding rate and factor concentrate use. Durability of the response seems to be unpredictable, perhaps attributable to the late intervention. An early radiosynovectomy might be more helpful in terms of stability of response to treatment.

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Section: Discussionmentioning

confidence: 64%

³²P colloid radiosynovectomy in treatment of chronic haemophilic synovitis: Iran experience

et al. 2007

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“…Heim et al studied radiosynoviorthesis in 115 patients with hemophilia with concomitant intraarticular steroid injections and supported the idea that the aim of steroid administration was to reduce the postradiation inflammatory response and to ensure that the needle tract remains free of radioactive material. 21 They did not report the leakage values.…”

Section: Discussionmentioning

confidence: 99%

Is Corticosteroid Coinjection Necessary for Radiosynoviorthesis of Patients with Hemophilia?

Gedik

Uğur²,

Atilla³

et al. 2004

Clinical Nuclear Medicine

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“…Takiplerinde ortalama kanama sıklığı ayda dörtten yılda ikiye düşmüş. Radyosinovektominin, hemofilik hastaların uzun dönem takiplerde %15 oranında kanamayı durdurduğu ve %80 oranında kanama sayısını azalttığı rapor edilmiştir (12,13).…”

Section: Discussionunclassified

Hemophilia Patients Treated with Radioactive Synovectomy

Karaman¹,

Akbayram²,

Garipardıç³

et al. 2014

ADUTFD

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ÖzetAMAÇ: Kolay, ucuz, invaziv olmayan, hastanede çok kısa süre kalmanın yeterli olduğu, gerektiğinde tekrarlanabilen bir girişim olan radyoaktif sinovektomi, yeterince faktör kullanılmayan ülkemiz gibi gelişmekte olan ülkeler için eklem sakatlıklarını önlemede değerli bir tedavi şekli olarak görünmektedir. Amaç, hedef eklemde kanama sıklığını azaltmak ve henüz kalıcı hasar oluşmadan kıkırdağı ve mevcut eklem fonksiyonlarını korumaktır. GEREÇ VE YÖNTEMLER:Çocuk Hematoloji Ünitemizde Hemofili A tanısıyla takipli ve radyoaktif sinovektomi yapılan yaşları 3-12 arasında değişen sekiz hastamızın verileri retrospektif olarak incelendi. BULGULAR: Radyoaktif sinovektomi; 8 Hemofili A hastasının 10 ayrı eklemine uygulandı. Uygulama günü preop faktör düzeyleri %50 olacak şekilde faktör uygulandı ve 3 gün sürdürüldü. Hastalarımızda herhangi bir komplikasyon gelişmediği gözlendi. SONUÇ:Hastalarımızda ortalama takip süresi 4 ay-2 yıl (9 ay) idi. Takipleri esnasında herhangi bir komplikasyon izlenmedi. Tüm hastalarda hedef eklemdeki kanama sayısı en az % 50 düzeyinde azaldı. Radyoaktif sinovektomi, ileri dönem hemofilik artropati bulguları gelişmeden hastalara uygulanabilirse daha iyi sonuçlar alınabilecektir. Hastaların ağrı derecelendirmesi ve klinik bulguları değer-lendirildiğinde, radyosinovektominin hastanın yaşam kalitesinin iyileştirilmesi açısından önemli olduğu gözardı edilmemelidir.ANAHTAR KELİMELER: Hemofili, sinovit, radyoizotop Abstract OBJECTIVE: Radioactive synovectomy is an easy, cheap,noninvasive, reproducible procedure when necessary and need short time to stay in hospital. It is a valuable treatment modality for prevention of joint disability in developing countries like our country in where there is not enough factor for using. The aim is to reduce frequency of bleeding in targeted joint and to preserve the available joint function and cartilage before permanent damage has occurred. MATERIALS AND METHODS:This is a retrospective analysis of our 8 patients with diagnosis of hemophilia A and treated with radioactive synovectomy in our pediatric hematology unit. RESULTS:Their ages varried between 3-12 years old. Radioactive synovectomy was applied to 10 different joints of these 8 hemophilia patient. The factor was given during the day of treatment and continued for 3 days so as to maintain the 50% factor level. No complication was seen in our patients. CONCLUSION:Radioactive synovectomy raised popularity recently in hemophilia management and it is valuable in prevention of possible joint disability. When comparing with surgical synovectomy, radiosynovectomy has many advantageous. This treatment modality is becoming more attractive in patients with recurrent hemartrozis of hemophilia patients because of it is a minimal invasive, easy usable procedure and does not need hospitalization, preserving joint movement ability, need of coagulation factor replacement is low and rehabilitation period is short. When considering pain scoring and clinical signs of patients, radiosynovectomy should not be ignored especially ...

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Synoviorthesis with radioactive Yttrium in haemophilia: Israel experience

Cited by 52 publications

References 18 publications

³²P colloid radiosynovectomy in treatment of chronic haemophilic synovitis: Iran experience

³²P colloid radiosynovectomy in treatment of chronic haemophilic synovitis: Iran experience

Is Corticosteroid Coinjection Necessary for Radiosynoviorthesis of Patients with Hemophilia?

Hemophilia Patients Treated with Radioactive Synovectomy

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Synoviorthesis with radioactive Yttrium in haemophilia: Israel experience

Cited by 52 publications

References 18 publications

32P colloid radiosynovectomy in treatment of chronic haemophilic synovitis: Iran experience

32P colloid radiosynovectomy in treatment of chronic haemophilic synovitis: Iran experience

Is Corticosteroid Coinjection Necessary for Radiosynoviorthesis of Patients with Hemophilia?

Hemophilia Patients Treated with Radioactive Synovectomy

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³²P colloid radiosynovectomy in treatment of chronic haemophilic synovitis: Iran experience

³²P colloid radiosynovectomy in treatment of chronic haemophilic synovitis: Iran experience