<sup>32</sup>P colloid radiosynovectomy in treatment of chronic haemophilic synovitis: Iran experience

Mortazavi, Seyed Mohammad Javad; Asadollahi, Saeed; Farzan, M; Shahriaran, Shahriar; Aghili, Mehrad; Izadyar, Sina; Lak, M

doi:10.1111/j.1365-2516.2006.01424.x

Cited by 33 publications

(37 citation statements)

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“…performed 66 radioisotopic synovectomy procedures in 53 patients. It effectively reduced the intra-articular bleeding rate and factor concentrate use [41]. …”

Section: Resultsmentioning

confidence: 99%

Haemophilia in the developing countries: the Iranian experience

Eshghi¹,

Mahdavi‐Mazdeh²,

Karimi³

et al. 2010

aoms

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IntroductionManagement of haemophilia and inherited bleeding disorders is a major challenge especially in developing countries, because of a shortage or absence of products, the cost and the infrastructural health problems. Development of local expertise which results in an improved outlook and reduction in mortality and morbidity in these countries can be helpful for advocators in other developing countries. However, very little information on demography and organizational models for haemophilia care in developing countries are available in the literature. Our aim is a comprehensive report of haemophilia status and its management in Iran.Material and methodsThe Management Center of Transplantation and Special Diseases (MCTSD) of the Ministry of Health of Iran decided to carry out a complete review and compilation of all of the published or available data about patients with haemophilia (PWH) in Iran: their health status, their management planning, organizations, treatment products, facilities and care problems during 2007.Results6496 patients with congenital bleeding disorders were registered. Most of them had haemophilia A and B and von Willebrand disease (vWD). However, rare bleeding disorders are seen more than expected. Inhibitor development is 14–28%. There are different data about virological status of PWH. Factor products and facilities are fairly available with more than 1.5 units per capita of inhabitant factor consumption.ConclusionsA national formulary based on facilities of the country should be considered and followed by collaboration among the Ministry Of Health, universities and non-governmental organizations.

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“…performed 66 radioisotopic synovectomy procedures in 53 patients. It effectively reduced the intra-articular bleeding rate and factor concentrate use [41]. …”

Section: Resultsmentioning

confidence: 99%

Haemophilia in the developing countries: the Iranian experience

Eshghi¹,

Mahdavi‐Mazdeh²,

Karimi³

et al. 2010

aoms

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“…RS is the optimal choice for treatment of patients with CHS, even in patients with anti-factor antibodies (inhibitors) [19][20][21][22][23] . The current recommendation is to use Yttrium-90 for the knees and Rhenium-186 for elbows and ankles and is supported by more than 40-years of experience with RS by the authors, who believe that the procedure is safe, easy to perform and economical technique for the management of CHS.…”

Section: Rsmentioning

confidence: 99%

Orthopedic disorders of the knee in hemophilia: A current concept review

Rodríguez-Merchán

Valentino

2016

WJO

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The knee is frequently affected by severe orthopedic changes known as hemophilic arthropathy (HA) in patients with deficiency of coagulation factor Ⅷ or Ⅸ and thus this manuscript seeks to present a current perspective of the role of the orthopedic surgeon in the management of these problems. Lifelong factor replacement therapy (FRT) is optimal to prevent HA, however adherence to this regerous treatment is challenging leading to breakthrough bleeding. In patients with chronic hemophilic synovitis, the prelude to HA, radiosynovectomy (RS) is the optimal to ameliorate bleeding. Surgery in people with hemophilia (PWH) is associated with a high risk of bleeding and infection, and must be performed with FRT. A coordinated effort including orthopedic surgeons, hematologists, physical medicine and rehabilitation physicians, physiotherapists and other team members is key to optimal outcomes. Ideally, orthopedic procedures should be performed in specialized hospitals with experienced teams. Until we are able to prevent orthopedic problems of the knee in PWH will have to continue performing orthopedic procedures (arthrocentesis, RS, arthroscopic synovectomy, hamstring release, arthroscopic debridement, alignment osteotomy, and total knee arthroplasty). By using the aforementioned procedures, the quality of life of PWH will be improved.

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“…Several radioisotopes can be used for radiosynovectomy and the ideal radioisotope should be a pure beta emitter, with a limited range of penetration through the tissues and a moderate physical half‐life. The most commonly used radioisotopes are Yttrium‐90 citrate colloid ( 90 Y), rhenium‐186 sulphide colloid ( 186 Re) and phosphorus chromic phosphate colloid ( 32 P) …”

Section: Introductionmentioning

confidence: 99%