Synergy of Non-antibiotic Drugs and Pyrimidinethiol on Gold Nanoparticles against Superbugs

Zhao, Yuyun; Chen, Zeliang; Chen, Yanfen; Xu, Jie; Li, Jinghong; Jiang, Xingyu

doi:10.1021/ja4058635

Cited by 170 publications

(131 citation statements)

References 33 publications

(37 reference statements)

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“…It was observed that bacteria moved away from the concentrated cells in the biofilm matrix and the upper regions of biofilms with NPs were detached, hence releasing some CeO 2 -NPs back to the bulk phase. 114 Hernandez-Delgadillo et al 115 showed that aqueous colloidal bismuth oxide NPs caused complete inhibition of biofilm formation. These investigators reported that citratecoated 6 nm platinum NPs, polyethylene glycol (PEG)-coated 11 nm gold NPs, and PEGcoated 8 nm iron oxide NPs considerably reduced bio-volume of the biofilm on the other hand citrate-coated 8 nm silver NPs have shown no significant impact in the reduction of volume of the pre-formed biofilms.…”

Section: Other Metal Nps Nms and Their Antibiofilm Prospectivementioning

confidence: 99%

Nanoparticles vs. biofilms: a battle against another paradigm of antibiotic resistance

2016

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Microbes form surface adherent community structures called biofilms and these biofilms play a critical role in infection. Biofilms impart antibiotic resistance and sometimes become recalcitrant to host immune system. It has reported by the National Institutes of Health that more than 80% of the bacterial infections caused by biofilms formation. Such kind of infection is also prevalent in biomedical devices which becomes a source of infection.The treatment of biofilm mediated infections is a big challenge that requires more sensitive and effective antibiofilm strategies for their removal. Nanoparticles targeted antibiofilm therapy has gained tremendous impetus in last decade due to their unique features. These are wonder particles having a wide spectrum biological applications and among these there antibiofilm activity is significantly useful. These particles are reactive entities and can easily infiltrate into the matrix which acts as a barrier for many antibiotics. Biomedical surfaces are also nano-functionalized by coating, impregnation or embedding nanomaterials to prevent biofilm formation. The study of interaction between nanoparticles and biofilm can provide us more insights about the mechanism of biofilm regulation. In this review article several classes of NPs effective against a broad range of microbial biofilms, both in vivo and in vitro are described. The application of nanoparticles against biofilm will help to fight resistant infections and will share its role in improving human health in the future.

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Section: Other Metal Nps Nms and Their Antibiofilm Prospectivementioning

confidence: 99%

Nanoparticles vs. biofilms: a battle against another paradigm of antibiotic resistance

2016

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“…Gold nanomaterials, in particular, serve as attractive materials for nucleic acid delivery2425, due to their advantages, including tunable sizes and surface properties, and multiple functional capabilities26272829. Gold nanoparticle (GNP)-based oligonucleotide delivery exhibited attractive biological properties and induced effective gene knockdown in cells and tissues without apparent cellular toxicity and off-target effects303132.…”

mentioning

confidence: 99%

Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer

et al. 2017

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Pancreatic cancer is one of the deadliest human cancers, whose progression is highly dependent on the nervous microenvironment. The suppression of gene expression of nerve growth factor (NGF) may have great potential in pancreatic cancer treatment. Here we show that gold nanocluster-assisted delivery of siRNA of NGF (GNC–siRNA) allows efficient NGF gene silencing and pancreatic cancer treatment. The GNC–siRNA complex increases the stability of siRNA in serum, prolongs the circulation lifetime of siRNA in blood and enhances the cellular uptake and tumour accumulation of siRNA. The GNC–siRNA complex potently downregulates the NGF expression in Panc-1 cells and in pancreatic tumours, and effectively inhibits the tumour progression in three pancreatic tumour models (subcutaneous model, orthotopic model and patient-derived xenograft model) without adverse effects. Our study constitutes a straightforward but effective approach to inhibit pancreatic cancer via NGF knockdown, suggesting a promising therapeutic direction for pancreatic cancer.

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“…aerogenes (Brown et al, ). Additionally, Zhao et al () reported that pyrimidinethiol‐modified AuNPs demonstrated synergistic antimicrobial effects against MDR E . faecium , MDR P .…”

Section: Treatments For Eskape Pathogensmentioning

confidence: 99%

Nanodelivery strategies for the treatment of multidrug‐resistant bacterial infections

Jiang

Lin

Taggart

et al. 2018

J of Interdiscip Nanomed

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One of the most important health concerns in society is the development of nosocomial infections caused by multidrug‐resistant pathogens. The purpose of this review is to discuss the issues in current antibiotic therapies and the ongoing progress of developing new strategies for the treatment of ESKAPE pathogen infections, which is acronymized for Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species. We not only examine the current issues caused by multidrug resistance but we also examine the barrier effects such as biofilm and intracellular localization exploited by these pathogens to avoid antibiotic exposure. Recent innovations in nanomedicine approaches and antibody antibiotic conjugates are reviewed as potential novel approaches for the treatment of bacterial infection, which ultimately may expand the useful life span of current antibiotics.

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Synergy of Non-antibiotic Drugs and Pyrimidinethiol on Gold Nanoparticles against Superbugs

Cited by 170 publications

References 33 publications

Nanoparticles vs. biofilms: a battle against another paradigm of antibiotic resistance

Nanoparticles vs. biofilms: a battle against another paradigm of antibiotic resistance

Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer

Nanodelivery strategies for the treatment of multidrug‐resistant bacterial infections

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