Synergistic osteogenic and angiogenic effects of KP and QK peptides incorporated with an injectable and self-healing hydrogel for efficient bone regeneration

Li, Runze; Zhou, Chen; Luo, H.; Li, Ruoyu; Chen, Danying; Zou, Xuenong; Wang, Weicai

doi:10.1016/j.bioactmat.2022.02.011

Cited by 43 publications

(41 citation statements)

References 74 publications

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“…1h). 36 However, G′ and G″ immediately recovered when the shear rate was reduced to 0.1%. This rapid recovery was also observed when the strain increased to 100%.…”

Section: Paper Biomaterials Sciencementioning

confidence: 94%

An injectable vitreous substitute with sustained release of metformin for enhanced uveal melanoma immunotherapy

Liu

Zhang

et al. 2022

Biomater. Sci.

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“…1h). 36 However, G′ and G″ immediately recovered when the shear rate was reduced to 0.1%. This rapid recovery was also observed when the strain increased to 100%.…”

Section: Paper Biomaterials Sciencementioning

confidence: 94%

An injectable vitreous substitute with sustained release of metformin for enhanced uveal melanoma immunotherapy

Liu

Zhang

et al. 2022

Biomater. Sci.

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“…More importantly, the degradation of these hydrogels results in amino acids that are safe and will not induce side effects or immune or inflammatory reactions inside the body [ 1 ]. In 2022, Li et al developed a novel self-healing and injectable hydrogel (GMO hydrogel) containing loaded KP and QK peptides to improve the vascularized regeneration of minor, irregular defects of bone [ 132 ]. In this hydrogel, the imine bonds between gelatin methacryloyl and oxidized dextran provides an excellent injectability and fittability.…”

Section: Biomedical Applications Of Peptide-based Hydrogelsmentioning

confidence: 99%

Peptide-Based Hydrogels: New Materials for Biosensing and Biomedical Applications

et al. 2022

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Peptide-based hydrogels have attracted increasing attention for biological applications and diagnostic research due to their impressive features including biocompatibility and biodegradability, injectability, mechanical stability, high water absorption capacity, and tissue-like elasticity. The aim of this review will be to present an updated report on the advancement of peptide-based hydrogels research activity in recent years in the field of anticancer drug delivery, antimicrobial and wound healing materials, 3D bioprinting and tissue engineering, and vaccines. Additionally, the biosensing applications of this key group of hydrogels will be discussed mainly focusing the attention on cancer detection.

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“…Injectable hydrogels allow in situ repair of cartilage defects by invasive techniques, wherein progenitor cells and growth factors can be delivered through hydrogel to enhance the clinical efficiency ( Li et al, 2022 ; Luo et al, 2022 ). In comparison to rigid scaffold implantation, hydrogel injection has more advantages in tissue engineering due to its flexible traits in shape adaptability, which is more potential in clinical applications ( Taymouri et al, 2021 ).…”

Section: Fabrication Strategymentioning

confidence: 99%

Advanced Hydrogels With Nanoparticle Inclusion for Cartilage Tissue Engineering

Zhang

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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Cartilage dysfunctions caused by congenital disease, trauma and osteoarthritis are still a serious threat to joint activity and quality of life, potentially leading to disability. The relatively well-established tissue engineering technology based on hydrogel is a promising strategy for cartilage defect repairing. However, several unmet challenges remain to be resolved before its wide application and clinical translation, such as weak mechanical property and compromised bioactivity. The development of nanomedicine has brought a new dawn to cartilage tissue engineering, and composite hydrogel containing nanoparticles can substantially mimic natural cartilage components with good histocompatibility, demonstrating unique biological effects. In this review, we summarize the different advanced nanoparticle hydrogels currently adopted in cartilage tissue engineering. In addition, we also discuss the various application scenarios including injection and fabrication strategies of nanocomposite hydrogel in the field of cartilage repair. Finally, the future application prospects and challenges of nanocomposite hydrogel are also highlighted.

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Synergistic osteogenic and angiogenic effects of KP and QK peptides incorporated with an injectable and self-healing hydrogel for efficient bone regeneration

Cited by 43 publications

References 74 publications

An injectable vitreous substitute with sustained release of metformin for enhanced uveal melanoma immunotherapy

An injectable vitreous substitute with sustained release of metformin for enhanced uveal melanoma immunotherapy

Peptide-Based Hydrogels: New Materials for Biosensing and Biomedical Applications

Advanced Hydrogels With Nanoparticle Inclusion for Cartilage Tissue Engineering

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