Synergistic  locoregional chemoradiotherapy using a composite liposome-in-gel system as an injectable drug depot

GuhaSarkar, Shruti; Pathak, K. A.; Sudhalkar, Niyati; More, Prachi; Goda, Jayant Sastri; Gota, Vikram; Banerjee, Rinti

doi:10.2147/ijn.s110525

Cited by 18 publications

(6 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intravesical liposome-in-gel systems have been developed to enhance drug retention in the bladder while reducing systemic levels, presenting a promising approach for intravesical applications [58]. Similarly, liposome-in-gel-paclitaxel systems have been investigated for regional delivery in chemoradiotherapy, resulting in increased cytotoxicity and reduction in tumor volume [59].…”

Section: Drug Deliverymentioning

confidence: 99%

“…Injectable hydrogels have gained popularity as versatile platforms for drug delivery due to their gelation upon injection, which enables localized and sustained drug release [4,55,56,60,63,64,[73][74][75][76][77][78]80,103]. Achieving targeted and localized drug delivery to specific sites, such as tumor cells or pathological areas, has been a major focus of research, and various strategies have been explored to achieve this objective [40,41,59,62,73,75,77].…”

Section: Perspectivementioning

confidence: 99%

See 1 more Smart Citation

Advancements and Applications of Injectable Hydrogel Composites in Biomedical Research and Therapy

Omidian

Chowdhury

2023

Gels

View full text Add to dashboard Cite

Injectable hydrogels have gained popularity for their controlled release, targeted delivery, and enhanced mechanical properties. They hold promise in cardiac regeneration, joint diseases, postoperative analgesia, and ocular disorder treatment. Hydrogels enriched with nano-hydroxyapatite show potential in bone regeneration, addressing challenges of bone defects, osteoporosis, and tumor-associated regeneration. In wound management and cancer therapy, they enable controlled release, accelerated wound closure, and targeted drug delivery. Injectable hydrogels also find applications in ischemic brain injury, tissue regeneration, cardiovascular diseases, and personalized cancer immunotherapy. This manuscript highlights the versatility and potential of injectable hydrogel nanocomposites in biomedical research. Moreover, it includes a perspective section that explores future prospects, emphasizes interdisciplinary collaboration, and underscores the promising future potential of injectable hydrogel nanocomposites in biomedical research and applications.

show abstract

Section: Drug Deliverymentioning

confidence: 99%

Section: Perspectivementioning

confidence: 99%

Advancements and Applications of Injectable Hydrogel Composites in Biomedical Research and Therapy

Omidian

Chowdhury

2023

Gels

View full text Add to dashboard Cite

show abstract

“…[57] Also beta-lapachone-loaded polymer implants were used for the treatment of prostate cancer. [58] Other applications have included, composite liposome-in-gel systems as injectable drug depots, [59] injectable in situ formation of carboxymethyl chitin hydrogel implants for 3D cell culture, [60] PLGA based DOX-loaded implants for local DOX release, [61] poly(D,L-lactide-co-glycolide)-based methotrexateloaded implants for enhanced anti-tumor efficacy against sarcoma 180, [62] paclitaxel-loaded injectable in situ-forming gels, [63] and injectable in situ-forming hydrogels for osteogenic differentiation of human turbinate mesenchymal stem cells. [64] An advanced hydrogel based on self-assembling peptides tethered with RADA16-GGQQLK (QLK) and RADA16-GGLRK-KLGKA (LRK) sequences was synthesized to promote the formation of capillary-like tubular endothelial structures, as well as supporting the survival of the embedded cells.…”

Section: Hydrogels For Local (In Situ) Administrationmentioning

confidence: 99%

Potential Applications of Advanced Nano/Hydrogels in Biomedicine: Static, Dynamic, Multi‐Stage, and Bioinspired

Ayoubi‐Joshaghani

Seidi

Azizi

et al. 2020

Adv Funct Materials

View full text Add to dashboard Cite

Novel advanced hydrogels can provide a versatile platform for controlled delivery and release of various cargos, with a myriad of biomedical applications. These gel-based nanostructures possess good biocompatibility, biodegradability, flexibility, multifunctionality, can respond to internal or external stimuli, and can adapt to their surrounding environment. This new generation of hydrogels is not only capable of serving as targeted drug delivery vehicles, but they can also perform a variety of tasks within living cells and organisms. In this review, advanced hydrogels are classified as static, dynamic, multistage, or bioinspired. They can be used as cell-free gene expression platforms for gene therapy. Administration of nanogel-based sprays can act as an immunovaccine priming macrophages toward the M1 phenotype to avoid cancer recurrence following surgery. Nanogels can also serve as a dual biosensing and capture platform for liquid biopsies, and can recognize and remove circulating cancer cells from the blood of cancer patients.

show abstract

“…On the other hand, the encapsulated liposomes act as drug pockets with enhanced stability, leading to a more sustained and prolonged drug release comparatively than that found for conventional liposomes [ 39 , 40 , 41 , 42 ] or native hydrogel matrices [ 25 ]. Liposomal hydrogel delivery systems have shown improved efficiency for the treatment of several inflammatory diseases [ 43 ] and chemotherapy [ 44 , 45 ] comparatively to conventional therapies, ascribed to their ability to provide longer-term and in situ release of the target therapeutic compound, minimizing the toxic side effects due to drug leakage.…”

Section: Introductionmentioning

confidence: 99%

Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules—An Insight into the Release Kinetics

et al. 2023

View full text Add to dashboard Cite

This work explores the unique features of magnetic-responsive hydrogels to obtain liposomal hydrogel delivery platforms capable of precise magnetically modulated drug release based on the mechanical responses of these hydrogels when exposed to an external magnetic field. Magnetic-responsive liposomal hydrogel delivery systems were prepared by encapsulation of 1,2-dipalmitoyl-sn-glycero-3-phosphocoline (DPPC) multilayered vesicles (MLVs) loaded with ferulic acid (FA), i.e., DPPC:FA liposomes, into gelatin hydrogel membranes containing dispersed iron oxide nanoparticles (MNPs), i.e., magnetic-responsive gelatin. The FA release mechanisms and kinetics from magnetic-responsive liposomal gelatin were studied and compared with those obtained with conventional drug delivery systems, e.g., free liposomal suspensions and hydrogel matrices, to access the effect of liposome entrapment and magnetic field on FA delivery. FA release from liposomal gelatin membranes was well described by the Korsmeyer–Peppas model, indicating that FA release occurred under a controlled diffusional regime, with or without magnetic stimulation. DPPC:FA liposomal gelatin systems provided smoother controlled FA release, relative to that obtained with the liposome suspensions and with the hydrogel platforms, suggesting the promising application of liposomal hydrogel systems in longer-term therapeutics. The magnetic field, with low intensity (0.08 T), was found to stimulate the FA release from magnetic-responsive liposomal gelatin systems, increasing the release rates while shifting the FA release to a quasi-Fickian mechanism. The magnetic-responsive liposomal hydrogels developed in this work offer the possibility to magnetically activate drug release from these liposomal platforms based on a non-thermal related delivery strategy, paving the way for the development of novel and more efficient applications of MLVs and liposomal delivery systems in biomedicine.

show abstract

Synergistic locoregional chemoradiotherapy using a composite liposome-in-gel system as an injectable drug depot

Cited by 18 publications

References 44 publications

Advancements and Applications of Injectable Hydrogel Composites in Biomedical Research and Therapy

Advancements and Applications of Injectable Hydrogel Composites in Biomedical Research and Therapy

Potential Applications of Advanced Nano/Hydrogels in Biomedicine: Static, Dynamic, Multi‐Stage, and Bioinspired

Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules—An Insight into the Release Kinetics

Contact Info

Product

Resources

About