Advancements and Applications of Injectable Hydrogel Composites in Biomedical Research and Therapy

Omidian, Hossein; Chowdhury, Soumi Roy

doi:10.3390/gels9070533

Cited by 23 publications

(9 citation statements)

References 163 publications

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“…The evaluation of drug release kinetics from injectable hydrogels involves the study of factors such as gelation time, drug loading efficiency, and drug release profiles (Singh et al, 2020). Researchers have employed techniques like diffusion studies, release kinetics analysis, and mathematical modeling to understand and optimize drug release from Tragacanth gum-based injectable hydrogels (Omidian and Chowdhury, 2023). Several examples demonstrate the effectiveness of injectable drug delivery using Tragacanth gum-based hydrogels.…”

Section: Tragacanth Gum-based Hydrogels For Injectable Drug Deliverymentioning

confidence: 99%

Tragacanth gum-based hydrogels for drug delivery and tissue engineering applications

Abdi,

Jain,

Patil

et al. 2024

Front. Mater.

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Natural polymers have many uses, and Tragacanth gum is just one of them. Many people are interested in natural gums because of their many attractive characteristics, such as being ‘green’ bio-based renewable materials, being easily accessible, inexpensive, and structurally diverse. One class of naturally occurring polysaccharides is called gum because of its tendency to create a gel or a thick solution. Among the many plant-based raw materials, these polysaccharide gums are abundant. Hydrogels, which are three-dimensional polymeric webs that can imitate live tissues, have demonstrated remarkable potential as adjustable biomaterials in numerous regenerative techniques due to their high water or biological exudate absorption capacities. Natural polysaccharides, often known as gums, are present in many different types of trees and possess many desirable properties, such as being renewable, biocompatible, biodegradable, non-toxic, and amenable to chemical modification. Many people are curious about certain parts of the food, water, energy, biotech, environmental, and healthcare sectors as of now. Gum, a type of very important and unique food ingredient, has many vital uses in the food business. Cosmetics, coating, photosensitive resin, fertilizer, casting, pharmaceuticals, and tobacco are just a few of the non-food businesses that make use of their strong water-affinity and structural plasticity. There are a lot of benefits to hydrogels made from natural gums as opposed to those made from synthetic sources. Synthesis hydrogel polymers have been the center of interest among these non-food applications because of their extensive use in the pharmaceutical and medical fields. The Tragacanth gum hydrogels used for medication delivery and tissue engineering have been the focus of this study. We also paid close attention to drug delivery, physical-chemical properties, and the extraction of Tragacanth gum. Our research has a wide range of biomedical applications, including tissue engineering for bone, skin, fixation of bone, periodontal, and cartilage. Possible futures based on hydrogels made of Tragacanth gum were likewise our primary focus.

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Section: Tragacanth Gum-based Hydrogels For Injectable Drug Deliverymentioning

confidence: 99%

Tragacanth gum-based hydrogels for drug delivery and tissue engineering applications

Abdi,

Jain,

Patil

et al. 2024

Front. Mater.

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“…Therefore, some substances with coagulation-promoting properties are added to the hemostatic material, such as gelatin, silk fibroin, Ca 2+ , nano clay, etc. − Hydroxyapatite (HAp) is an inorganic mineral that exists in bone tissue. It has good biocompatibility and can promote bone tissue repair, so it is often used as bone tissue engineering biomaterials . In, addition, HAp has the property of releasing Ca 2+ , so it can not only promote bone tissue repair but also promote blood coagulation. , …”

Section: Introductionmentioning

confidence: 99%

“…It has good biocompatibility and can promote bone tissue repair, so it is often used as bone tissue engineering biomaterials. 27 In, addition, HAp has the property of releasing Ca 2+ , so it can not only promote bone tissue repair but also promote blood coagulation. 28,29 On the other hand, a simple and efficient hydrogel preparation process is desirable.…”

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confidence: 99%

Terpolymer-Hydroxyapatite Hybrid Hydrogel Prepared by Photopolymerization Under Green LED Irradiation for Wound Hemostasis

Zhao,

Deng,

et al. 2024

ACS Appl. Polym. Mater.

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Multifunctional materials with hemostasis, adhesive, and antibacterial properties must be developed to meet the demand for wound hemostasis. In this work, a hybrid hydrogel (ATD-HAp hydrogel) based on a terpolymer and hydroxyapatite (HAp) was prepared by photopolymerization within 1 min under green LED irradiation. The polymer chains of ATD-HAp hydrogel with adjustable tensile and adhesion properties and antibacterial properties were formed by copolymerization of acrylamide, N-[tris(hydroxymethyl)methyl] acrylamide, and dimethyldiallylammonium chloride and methacrylated carboxymethyl chitosan as a cross-linking agent. HAp was added to the hydrogel to release Ca 2+ to promote coagulation. The results showed that ATD-HAp hydrogel had good tensile (196.7 kPa), wet-adhesive (10.3 kPa), self-healing, antibacterial properties, and coagulation. And the ATD-HAp hydrogel had excellent blood compatibility and biocompatibility. Furthermore, the experimental results of the hemostasis model in mice proved that the ATD-HAp hydrogel can significantly shorten the hemostasis time and reduce blood loss. Therefore, the ATD-HAp hydrogel has great potential in the field of wound hemostasis.

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“…Furthermore, injectable hydrogels can fill minor and irregular wounds caused by injuries and can also be implanted into treatment sites that are difficult to access. Equally significant, the injectable hydrogel benefits from gradually undergoing the "sol-gel" phase transition in physiological conditions, thereby accomplishing precise treatment (Liao et al 2020;Omidian and Chowdhury 2023).…”

Section: Introductionmentioning

confidence: 99%

Thermosensitive injectable polysaccharide-based hydrogels: Gelation mechanisms, synthetic strategies, biomedical applications, and challenges

Sun,

Jiang

et al. 2024

BioRes

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In recent years, thermosensitive polysaccharide-based injectable hydrogels have gained increasing attention in biomedical applications, including wound healing, drug delivery, and cartilage repair. These hydrogels have favorable biocompatibility, biodegradability, and tunable physical and chemical properties. Thermosensitive polysaccharide-based injectable hydrogels are a class of intelligent soft matter material. They can undergo a reversible liquid-solid transition when exposed to temperature stimuli. Therefore, their precursor solutions can be accurately inserted into target sites with irregular geometries in a minimally invasive way and then transformed into gels in situ by the organism’s temperature stimulation to deliver biologically active molecules. This review summarizes the recent developments of thermosensitive injectable polysaccharide-based hydrogels. The focus is on the mechanism of sol-gel phase transition, as well as the design and preparation of thermosensitive polysaccharides and their applications in biomedical fields. In addition, the outlook of the challenges in biomedical applications is provided at the end of the paper.

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Advancements and Applications of Injectable Hydrogel Composites in Biomedical Research and Therapy

Cited by 23 publications

References 163 publications

Tragacanth gum-based hydrogels for drug delivery and tissue engineering applications

Tragacanth gum-based hydrogels for drug delivery and tissue engineering applications

Terpolymer-Hydroxyapatite Hybrid Hydrogel Prepared by Photopolymerization Under Green LED Irradiation for Wound Hemostasis

Thermosensitive injectable polysaccharide-based hydrogels: Gelation mechanisms, synthetic strategies, biomedical applications, and challenges

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