Synergistic laxative effect of fermented rice extracts with probiotic-containing yogurt in normal rats

Lee, Jongkwang; Kim, Joo Wan; Kim, Ki‐Young; Ha, Yu-Mi; Sohn, Jae Hak; Ku, Sae‐Kwang; Choi, Jae‐Suk

doi:10.1007/s13530-014-0192-y

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…The increased fecal water content and fecal pellet number discharged detected in rats treated with FBe (100–300 mg/kg) compared with LP control rats suggest that FBe has promising laxative properties on spastic constipation. Decreases in fecal surface mucous content and increases in remnant fecal pellet number in the colon lumen have previously been observed in constipation [20, 36, 46, 58] as well as treatment with LP [21, 22]. Our results showed decreases in remnant fecal pellet number in the colon lumen and increases in surface mucous content following treatment with FBe (100–300 mg/kg), providing support for the hypothesis that FBe has promising laxative effects at these doses.…”

Section: Discussionmentioning

confidence: 98%

“…Reduction in mucous production in the colonic mucosa on histopathological assessments are directly related with constipation [58]; specifically, marked decreases in the thickness of the colonic mucosa layer and mucous-producing cells have been observed [20–22, 36, 59]. Additionally, treatment with 3 mg/kg of LP has been associated with marked decreases in mucosa thickness and colonic mucous-producing cells [21, 22].…”

Section: Discussionmentioning

confidence: 99%

“…Dietary habits, chemical compounds such as morphine, and psychological stress have been considered as the causes of constipation [2, 20–22]. Normal rats are also useful experimental animals with regard to detecting various digestive disorders [20, 34–36]. It has been established that loperamide (LP) can induce delays in colonic transit due to its inhibition of stool frequency in mice and increase in colonic contractions, resulting in spastic constipation [37].…”

Section: Introductionmentioning

confidence: 99%

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Laxative effects of triple fermented barley extracts (FBe) on loperamide (LP)-induced constipation in rats

Lim¹,

Song

Park

et al. 2019

BMC Complement Altern Med

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Background Constipation, a common health problem, causes discomfort and affects the quality of life. This study intended to evaluate the potential laxative effect of triple fermented barley ( Hordeum vulgare L.) extract (FBe), produced by saccharification, Saccharomyces cerevisiae, and Weissella cibaria , on loperamide (LP)-induced constipation in Sprague-Dawley (SD) rats, a well-established animal model of spastic constipation. Methods Spastic constipation was induced via oral treatment with LP (3 mg/kg) for 6 days 1 h before the administration of each test compound. Similarly, FBe (100, 200 and 300 mg/kg) was orally administered to rats once a day for 6 days. The changes in number, weight, and water content of fecal, motility ratio, colonic mucosa histology, and fecal mucous contents were recorded. The laxative properties of FBe were compared with those of a cathartic stimulant, sodium picosulfate. A total of 48 (8 rats in 6 groups) healthy male rats were selected and following 10 days of acclimatization. Fecal pellets were collected one day before administration of the first dose and starting from immediately after the fourth administration for a duration of 24 h. Charcoal transfer was conducted after the sixth and final administration of the test compounds. Results In the present study, oral administration of 100–300 mg/kg of FBe exhibited promising laxative properties including intestinal charcoal transit ratio, thicknesses and mucous producing goblet cells of colonic mucosa with decreases of fecal pellet numbers and mean diameters remained in the lumen of colon, mediated by increases in gastrointestinal motility. Conclusion Therefore, FBe might act as a promising laxative agent and functional food ingredient to cure spastic constipation, with less toxicity observed at a dose of 100 mg/kg.

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