Laxative Effects of Triple-Fermented Barley Extracts (Fbe) in Normal Rats

Lim, Jong‐Min; Song, Chang‐Hyun; Park, Su‐Jin; Park, Dong-Chan; Jung, Go‐Woon; Cho, Hyung-Rae; Ku, Sae Kwang; Choi, Jae‐Suk

doi:10.1007/s13530-018-0353-5

Cited by 4 publications

(5 citation statements)

References 37 publications

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“…Various fermentation processes increase the bioavailability of phenolic compounds of barley and increase various antioxidantbased pharmacological activities (Giriwono et al, 2010(Giriwono et al, , 2011Hokazono, Omori, Yamamoto, et al, 2010;Iguchi et al, 2009;Kim et al, 2007). In our previous reports on the laxative effects of FBe on normal rats (Lim et al, 2018a) and loperamide-induced constipated rats (Lim et al, 2018b), FBe showed favorable laxative effects at dose levels of 300, 200, and 100 mg/kg. In this study, three different doses of (Grover et al, 2001) in this experiment.…”

Section: Discussionmentioning

confidence: 76%

“…In this study, three different doses of (Grover et al, 2001) in this experiment. The doses of FBe, 100, 200, and 300 mg/kg, were selected, similar to those in our previous reports on the laxative effects of FBe on normal rats (Lim et al, 2018a) and loperamide-induced constipated rats (Lim et al, 2018b), and the dose level of RA was also selected as 100 mg/kg according to a previous efficacy study (Grover et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…A number of barley extracts produced from fermentation have been reported to be potent pharmacological effects, especially antioxidant (Giriwono et al, 2011), uric acid lowering (Hokazono, Omori, Yamamoto, Akaoka, & Ono, 2010), antiatopic dermatitis Iguchi, Kawata, Watanabe, Mazumder, & Tanabe, 2009), hepatoprotective (Giriwono et al, 2010(Giriwono et al, , 2011, and immunostimulatory (Kim et al, 2007) activities, compared with nonfermented extracts. In our previous reports on the laxative effects of fermented barley extract (FBe) in normal rats (Lim et al, 2018a) and loperamide-induced constipation rats (Lim et al, 2018b), in which FBe showed favorable laxative effects at concentrations of 300, 200, and 100 mg/kg. However, there are no systemic assessments for gastroprotective effects of fermented barley extracts, to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 99%

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Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Lim¹,

Song

Park

et al. 2018

Food Science & Nutrition

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This study was designed to observe the possible protective effects of a triple‐fermented barley (Hordeum vulgare L.) extract (FBe) obtained by saccharification and using Saccharomyces cerevisiae and Weissella cibaria in alleviating gastric damage induced by a hydrochloric acid (HCl) and ethanol (EtOH) mixture in mice. After oral administration of FBe (300, 200, and 100 mg/kg) followed by 1 hr before and after the single treatment of HCl/EtOH (H/E) mixture, the hemorrhagic lesion scores, histopathology of the stomach, gastric nitrate/nitrite content, lipid peroxidation, and antioxidant defense systems including catalase and superoxide dismutase activities were observed. Following a single oral treatment of H/E‐induced gastric damages as measured by hemorrhagic gross lesions and histopathological gastric, ulcerative lesions were significantly and dose‐dependently (p < 0.01 or p < 0.05) inhibited in mice, when all three different doses of FBe were administered as compared to those in H/E control mice. In particular, FBe also increased gastric nitrate/nitrite content and strengthened the antioxidant defense, with a decrease in the level of gastric lipid peroxidation, but increased the activities of CAT and SOD. Moreover, the effects of FBe are comparable to that of ranitidine, a reference drug. The obtained results suggest that this fermented barley extract prevented mice from H/E‐induced gastric mucosal damages through the suppression of inflammatory responses and oxidative stress‐responsive free radicals. Thus, FBe can be useful to treat patients suffering from gastric mucosal disorders as a potent food supplement, and thereby, it would increase the necessity of application in the food industry.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Lim¹,

Song

Park

et al. 2018

Food Science & Nutrition

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“…The inhibitory effects were similar to the commercially available anti-ulcer drugs, such as ranitidine (100 mg kg − 1 ) and omeprazole (10 mg kg − 1 ). In our previously study, FBe (200 and 300 mg kg − 1 ) also indicated satisfactory laxative effects, mediated by the increase in gastrointestinal motility in normal rats [20]. Hence, FBe, as a potent food supplement, can be suitable for patients suffering from gastric mucosal disorders.…”

Section: Discussionmentioning

confidence: 94%

“…It is noted that fermented barley extract shows potent antioxidant potential in various in vivo models [20, 21], and indomethacin induces gastric ulcer in Sprague-Dawley animal models [6, 10]. This gained our attention to address the possible protective effect of fermented barley against IND-induced gastric ulcers in Sprague-Dawley rat model.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of triple fermented barley extract (FBe) on indomethacin-induced gastric mucosal damage in rats

Lim¹,

Song

Park

et al. 2019

BMC Complement Altern Med

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Background Hordeum vulgare L (barley) contains numerous phenolic substances with proven anticancer, antioxidant and gastroprotective activities. Saccharification increases the functionality and bioavailability of these compounds thus can aid in the development of a natural product based medicine. This study aimed to investigate the possible gastroprotective effects of saccharification on the indomethacin (IND)-induced gastric ulcers in rats using Weissella cibaria - and Saccharomyces cerevisiae -triple fermented H. vulgare extract (FBe). Methods In total, 60 healthy male 6-week old Sprague-Dawley SD (SPF/VAF Outbred CrljOri:CD1) rats were commercially purchased. The FBe extract (100, 200, and 300 mg kg − 1 ) was orally administered 30 min before an oral treatment of IND (25 mg kg − 1 ). Six hours after IND treatment, variations in the histopathology, myeloperoxidase (MPO) activity, gross lesion scores, lipid peroxidation, and antioxidant defense system component (superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH)) levels were measured. Results FBe treatment showed significant ( p < 0.01 or p < 0.05) and dose-dependent decrease in gastric mucosal damage. In the present study hemorrhagic gross lesions, gastric MPO activity, and histopathological gastric ulcerative lesions were observed in IND-treated rats compared to the IND control rats. In particular, FBe, in a dose-dependent manner, strengthened the antioxidant defense systems, decreased lipid peroxidation and CAT activity by increasing the GSH levels and SOD activity, respectively. The 200 mg kg − 1 dose of FBe was similarly gastroprotective as the 10 mg kg − 1 dose of omeprazole in rats with IND-induced gastric mucosal damage. Conclusions The findings of the present study show that an oral administration of FBe had positive gastroprotective effects through strengthening the body antioxidant defense system and anti-inflammatory effects.

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Elachi Lemon (Citrus limon) Peel and Pulp: Antioxidant, Antimicrobial, Anticoagulant Activities, Bioactive Compounds, Minerals, and Heavy Metals

Shahad

Kabir

Hasan

et al. 2021

CBC

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Background: According to a number of previous studies, citrus fruits are rich in phytochemicals, minerals and bioactive compounds. Objective: The aim of this study was to investigate the antioxidant, antimicrobial and anticoagulant activities, phytonutrients, bioactive compounds, mineral and heavy metals in peel and pulp of Elachi lemon (Citrus limon). Methods: Phytochemical screening was performed to estimate the total polyphenol, flavonoid, tannin, reducing sugar, total protein and vitamin C contents. High performance liquid chromatography was performed to determine the concentrations of phenolics and ascorbic acid. Antioxidant activities were evaluated by measuring 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, reducing power assay and ferric reducing antioxidant power (FRAP) assay. Antibacterial activity was evaluated by disc diffusion method and minimum inhibitory concentration (MIC). Besides estimating heavy metals and minerals, activated partial thromboplastin time (aPTT) and prothrombin time (PT) were observed for detecting anticoagulant activity. Results: In case of antioxidant and antimicrobial activities, pulp was found to be richer. Both the peel and pulp showed similar anticoagulant activities. Among the phytonutrients, protein content was richer in peel that in pulp. Catechin, rutin, tannic, gallic and vanilic acids were detected in peel whereas in pulp quercetin, tannic and gallic acids were found. Pb, Cr, Cd were present in a negligible amount whereas, Co, Cu and Fe content were high in both the peel and pulp. Conclusion: This study exhibits that both the peel and the pulp Citrus limon is a rich source of antioxidant, antimicrobial, anticoagulant, minerals and various bioactive compounds with nutritional values.

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Laxative Effects of Triple-Fermented Barley Extracts (Fbe) in Normal Rats

Cited by 4 publications

References 37 publications

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Protective effects of triple fermented barley extract (FBe) on indomethacin-induced gastric mucosal damage in rats

Elachi Lemon (Citrus limon) Peel and Pulp: Antioxidant, Antimicrobial, Anticoagulant Activities, Bioactive Compounds, Minerals, and Heavy Metals

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