2006
DOI: 10.1007/s10540-006-9012-1
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Abstract: The present report shows that thymocyte death, induced by glucocorticoids, may be modulated in vivo by ouabain. Young, ten days old, mice injected with 140 mg/kg sodium succcinate of hydrocortisone (HC) intraperitonially (i.p.) displayed, 24 h after the injection, a decrease in thymus size and cellular content, an effect that was magnified when ouabain (OUA) 0.56 mg/kg, i.p. was given 1 h prior to the HC injection. Ouabain per se was not capable of producing these changes. Both HC and the combination OUA plus … Show more

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Cited by 26 publications
(24 citation statements)
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“…The interactions between signaling through the Na + /K + -ATPase and cell death seem to be both complex and variable, depending on cell type and on treatment conditions (Winnicka et al, 2007; Newman et al, 2008). It should also be noted that beyond death signals, the Na + /K + -ATPase signal cascade seems to be involved in a variety of cell biological functions including adhesion and differentiation (Zhang et al, 1991; Numazawa et al, 1994; Kawazoe et al, 1999; Ghoumari et al, 2006; Larre et al, 2006; Rodrigues-Mascarenhas et al, 2006). …”
Section: Endogenous Cardiotonic Steroids and Cell Signalingmentioning
confidence: 99%
“…The interactions between signaling through the Na + /K + -ATPase and cell death seem to be both complex and variable, depending on cell type and on treatment conditions (Winnicka et al, 2007; Newman et al, 2008). It should also be noted that beyond death signals, the Na + /K + -ATPase signal cascade seems to be involved in a variety of cell biological functions including adhesion and differentiation (Zhang et al, 1991; Numazawa et al, 1994; Kawazoe et al, 1999; Ghoumari et al, 2006; Larre et al, 2006; Rodrigues-Mascarenhas et al, 2006). …”
Section: Endogenous Cardiotonic Steroids and Cell Signalingmentioning
confidence: 99%
“…The inhibitory effect observed on CFU-S cells when bone marrow was treated in vitro with ouabain and subsequently transferred in vivo, was produced when concentrations of 10 −11 , 10 −9 or 10 −6 M were used (Spivak et al 1980). The dose of ouabain used in vivo in this study was previously determined by Rodrigues-Mascarenhas et al (2006) and coincides with pharmacological concentration (10 −7 M). In stress situations the concentration can rise above 10 −7 M which corresponds to the dose used in vivo in this study (Bauer et al 2005), however, physiological concentrations of ouabain are between 10 −11 and 10 −9 M in plasma (Hansen 2003).…”
Section: Discussionmentioning
confidence: 99%
“…Both groups were treated for 3 consecutive days. The concentrations used throughout this study were determined before (Rodrigues-Mascarenhas et al 2006). To use as a positive control, in some experiments a third group was added and treated with 140 mg/kg hydrocortisone i.p.…”
Section: Treatment In Vivo With Ouabainmentioning
confidence: 99%
See 1 more Smart Citation
“…In vivo administration of ouabain alone does not induce cell death in double-positive thymocytes in mice but synergizes with glucocorticoids inducing apoptosis of these cells (Rodrigues-Mascarenhas et al, 2006).…”
Section: Introductionmentioning
confidence: 98%