Dynamics of murine B lymphocytes is modulated by in vivo treatment with steroid ouabain

Silva, Joyle Moreira Carvalho da; Azevedo, Augusto das Neves; Barbosa, Rebeca Pinheiro dos Santos; Vianna, Thais Andressa Gonçalves; Fittipaldi, Juliana; Teixeira, Mariana Pires; Canto, Fábio Barrozo do; Costa, Kelli Monteiro da; Pozzatti, Rodrigo Roitman; Cabral, Vinicius Ribeiro; Rumjanek, Vivian M.; Paiva, Luciana Souza de

doi:10.1016/j.imbio.2015.09.020

Cited by 9 publications

(3 citation statements)

References 44 publications

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“…Ouabain is also able to modulate in vivo B lymphocytes dynamics, decreasing mature B cells in the bone marrow, spleen and peripheral blood (de Paiva et al, 2011 ), although IgG and IgM levels were not affected by ouabain. On the other hand, there was an increase in B lymphocytes of mesenteric lymph node, probably by CD62L reduced and CXCR5 increased expression (da Silva et al, 2015 ).…”

Section: Ouabain and Immune Systemmentioning

confidence: 99%

Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain

et al. 2017

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Since the discovery of ouabain as a cardiotonic steroid hormone present in higher mammals, research about it has progressed rapidly and several of its physiological and pharmacological effects have been described. Ouabain can behave as a stress hormone and adrenal cortex is its main source. Direct effects of ouabain are originated due to the binding to its receptor, the Na+/K+-ATPase, on target cells. This interaction can promote Na+ transport blockade or even activation of signaling transduction pathways (e.g., EGFR/Src-Ras-ERK pathway activation), independent of ion transport. Besides the well-known effect of ouabain on the cardiovascular system and blood pressure control, compelling evidence indicates that ouabain regulates a number of immune functions. Inflammation is a tightly coordinated immunological function that is also affected by ouabain. Indeed, this hormone can modulate many inflammatory events such as cell migration, vascular permeability, and cytokine production. Moreover, ouabain also interferes on neuroinflammation. However, it is not clear how ouabain controls these events. In this brief review, we summarize the updates of ouabain effect on several aspects of peripheral and central inflammation, bringing new insights into ouabain functions on the immune system.

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Section: Ouabain and Immune Systemmentioning

confidence: 99%

Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain

et al. 2017

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“…Therefore, ouabain regulates the dynamic of В-lymphocyte settling in peripheral organs. It was noted that production of total IgM и IgG in serum of animal injected with ouabain in vivo did not change [118]. Beside this bufalin increased B-cell proliferation from leukemic BALB/c mice compared with the leukemic control group at doses 0.1 and 0.2 mg/kg.…”

Section: B Cellsmentioning

confidence: 92%

Mechanisms providing effects of cardiotonic steroids in mammalian cells with special attention to blood cells

Poluektov,

Lopina,

Strelkova

et al. 2023

Preprint

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Cardiotonic steroids (CTS) are a group of steroid compounds derived from certain plants and animals. CTS are selective inhibitors of Na,K-ATPase, so for a long time they were widely used for medical purposes to treat heart failure and some other diseases. However, over time, doctors gradually began to refuse this group of drugs due to their narrow therapeutic range and a number of serious side effects. However, in parallel with the rise and fall of interest in CTS as a drug, interest in them as a single class of high-affinity Na,K-ATPase inhibitors has only increased. Numerous data on the effect of CTS on signaling cascades and cell viability made impelling a search for a rationale for the existence of such a subtle biological regulator. A large number of studies devoted to the potential use of CTS in the treatment of neurodegenerative, oncological, immune and other diseases "revitalized" the already "written off" group of the drugs. If initially the role of exogenous (mainly plant origin) CTS was studied, then by the 90s of the XX century the study of the role of endogenous CTS and their regulatory effects became a popular trend in biology and physiology. The role of endogenous CTS was studied in details in the pathogenesis of cardiovascular diseases [1]. A large number of researchers have unanimously stated that endogenous CTS are very complex regulators of the development of pathological processes; however, the exact cause-and-effect relationship that would unambiguously explain the processes of synthesis, utilization, and the role of endogenous CTS has not yet been established. The effects of CTS in the frame of various regulatory schemes have been described, but the predominant number of studies was devoted to arterial hypertension, heart and renal failure, cancer [2–4], aging [5,6], and neuroinflammation. The effects of both endo- and exogenous CTS on blood cells and have been studied to a much lesser extent.

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“…Furthermore, it was also evidenced that ouabain negatively modulates the number of B lymphocytes in the bone marrow, spleen, and peripheral blood (de Paiva et al, 2011), without, however, changing the levels of immunoglobulin G (IgG) and M (IgM). On the other hand, ouabain induces an increase in the number of B lymphocytes in the mesenteric lymph nodes, probably due to the reduction in the expression of the adhesion molecule CD62L and the chemokine receptor CXCR5 (da Silva et al, 2016).…”

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confidence: 99%

Neuroinflammation and Neutrophils: Modulation by Ouabain

et al. 2022

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Cardiotonic steroids are natural compounds that present many physiological and pharmacological functions. They bind Na+/K+-ATPase (NKA) modifying cellular ion concentration and trigger cell signaling mechanisms without altering ion balance. These steroids are known to modulate some immune responses, including cytokine production, neutrophil migration, and inflammation (peripherally and in the nervous system). Inflammation can occur in response to homeostasis perturbations and is related to the development of many diseases, including immune-mediated diseases and neurodegenerative disorders. Considering the neutrophils role in the general neuroinflammatory response and that these cells can be modulated by cardiac steroids, this work aims to review the possible regulation of neutrophilic neuroinflammation by the cardiac steroid ouabain.

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Dynamics of murine B lymphocytes is modulated by in vivo treatment with steroid ouabain

Cited by 9 publications

References 44 publications

Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain

Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain

Mechanisms providing effects of cardiotonic steroids in mammalian cells with special attention to blood cells

Neuroinflammation and Neutrophils: Modulation by Ouabain

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