2010
DOI: 10.1016/j.phymed.2009.07.008
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Synergism and postantibiotic effect of tobramycin and Melaleuca alternifolia (tea tree) oil against Staphylococcus aureus and Escherichia coli

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Cited by 124 publications
(87 citation statements)
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“…The primary one is likely responsible for the inhibition of protein synthesis whereas the secondary one is related to the misreading of the messenger RNA [29]. Tob has also previously been used to treat P. aeruginosa infections in patients with cystic fibrosis [30,31], and has been described by D'Arrigo et al to show excellent in vitro and clinical activities against susceptible strains of E. coli and S. aureus by inhibiting plasma membrane functions and by targeting ribosomal sites [32]. However, overuse of antibiotics in medicine promoted the evolution of some species of bacteria to infer resistance.…”
Section: Resultsmentioning
confidence: 99%
“…The primary one is likely responsible for the inhibition of protein synthesis whereas the secondary one is related to the misreading of the messenger RNA [29]. Tob has also previously been used to treat P. aeruginosa infections in patients with cystic fibrosis [30,31], and has been described by D'Arrigo et al to show excellent in vitro and clinical activities against susceptible strains of E. coli and S. aureus by inhibiting plasma membrane functions and by targeting ribosomal sites [32]. However, overuse of antibiotics in medicine promoted the evolution of some species of bacteria to infer resistance.…”
Section: Resultsmentioning
confidence: 99%
“…The time-kill test was performed according to D Arrigo and others 26 to determine the killing kinetics of 1-octen-…”
Section: Time-kill Analysismentioning
confidence: 99%
“…The most of them are able to suppress a number of microbial virulence factors (such as inhibition of biofilm formation, reduction of host ligands adhesion and neutralization of bacterial toxins) and show synergistic effect with antibiotics [38]. Several studies on the antibacterial activity of flavonoid-rich products was reported that new compounds of flavonoid with bactericidal rather than bacteriostatic effect was increasing the activity of antibiotics through synergistic interactions [5,16,21]. Staphylococcus aureus and methicillin resistant S. aureus (MRSA) are among the most significant gram-positive pathogens.…”
Section: Introductionmentioning
confidence: 99%