Interaction with Polyphenols and Antibiotics

Abstract

aureus) and gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa).These are found to be more efficient against the E. coli, L. monocytogenes, P. aeruginosa and S. aureus than antibiotics such as gentamicin and streptomycin. The kaempferol and quercetin showed synergistic effect with ciprofloxacin and rifampicin against S. aureus and methicillin resistant S. aureus (MRSA). Epigallocatechin gallate (EGCG) acts synergistically with various β-lactam antibiotics against MRSA. In particular, the epicatechin, epigallocatechin (EGC), EGCG and gallocatechin gallate from Korean green tea has antibacterial activity against MRSA clinical isolates and the combination of tea polyphenols and oxacillin was synergistic for all the clinical MRSA isolates.

Global Downregulation of Penicillin Resistance and Biofilm Formation by MRSA Is Associated with the Interaction between Kaempferol Rhamnosides and Quercetin

“…Interestingly, neither the combination of quercetin and penicillin G nor the combination of kaempferol-3,7-dirhamnoside and penicillin G appeared to synergistically inhibit the growth of representative strains tested in this study (data not shown). This is in agreement with a previous finding that kaempferol and quercetin had mild inhibitory effects on β-lactamase when used alone but exhibited excellent β-lactamase inhibition when used in combination with rifampicin ( 27 ). Therefore, the combined antibacterial effect of GE-EE with penicillin G was likely to depend on the interaction of kaempferol glycosides and quercetin with penicillin G. The combination of GE-EE with ceftazidime, erythromycin, levofloxacin, or vancomycin did not show a synergistic inhibitory activity against MRSA strains.…”

Effect of Marination with Black Currant Juice on the Formation of Biogenic Amines in Pork Belly during Refrigerated Storage

“…Ferulic acid is one of several phenols with antibacterial activity against pathogenic bacteria. Several reports found that ferulic acid had high antibacterial activity against E. coli and P. aeruginosa (MIC of E. coli and P. aeruginosa were 100 μg/mL) ( Borges et al, 2013 ; Cho et al, 2017 ). The possible mechanism for antimicrobial effect of phenolic compounds are known as altering microbial cell permeability, which interfering with membrane function such as nutrient uptake, electron transport, enzyme activity, protein and nucleic acid synthesis ( Abu-Salem et al, 2011 ).…”

The Structural Changes in the Membranes of Staphylococcus aureus Caused by Hydrolysable Tannins Witness Their Antibacterial Activity

“…The use of combinations of antibiotics and natural substances with antimicrobial properties may be an effective strategy. From these perspectives, polyphenols may increase the activity of traditional antibiotics used against a wide set of bacteria [27][28][29][30].…”