Synergic Effects of Magnetic Nanoparticles on Hyperthermia-Based Therapy and Controlled Drug Delivery for Bone Substitute Application

Salmani, Mohammad Mehdi; Hashemian, Mohammad; Yekta, Hamed Joneidi; Nejad, Mazyar Ghadiri; Saber‐Samandari, Saeed; Khandan, Amirsalar

doi:10.1007/s10948-020-05530-1

Cited by 39 publications

(13 citation statements)

References 57 publications

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“…In this study, the author loaded collagen microsphere containing BG nanopowder with different content of doped Ce into PCL fibrous scaffolds and their bioactivity and biocompatibility were evaluated in detail. The results confirmed the positive effect of the combination of Ce doped BG nanoparticles encapsulated collagen microspheres on the bioactivity and cell performance of PCL fibers for bone tissue engineering applications 41–62 …”

Section: Resultssupporting

confidence: 61%

Fabrication of fibrous poly (ɛ‐caprolactone) nano‐fibers containing cerium doped‐bioglasses nanoparticles encapsulated collagen

Sahrapeyma

Asefnejad

Azami

et al. 2021

J of Applied Polymer Sci

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Novel nanosized designed ceramic powders, cerium (Ce) doped bioglass (BG) with various doped Ce content, were synthesized by sol-gel method in order to be employed in the development of PCL fibrous scaffold for bone tissue engineering applications. Characterization techniques such as X-ray diffraction analysis, transmission electron microscopy, Fourier transform infrared spectroscopy, and energy-dispersive X-ray spectroscopy were employed to evaluate the developed Ce doped BG powders. The results confirmed successful doping of Ce inside BG structure. 0, 1, 3, and 10 wt% Ce doped 58S BG were successfully encapsulated in the collagen microspheres by water-in-oil emulsion method and the average particle size and hydrodynamic diameter of microspheres were determined using scanning electron microscopy and dynamic light scattering analysis, respectively. Next, 0, 1, 3, and 10 wt% Ce doped 58S BG encapsulated collagen microspheres were loaded inside the Poly(ϵ-caprolactone) fibrous scaf-

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Section: Resultssupporting

confidence: 61%

Fabrication of fibrous poly (ɛ‐caprolactone) nano‐fibers containing cerium doped‐bioglasses nanoparticles encapsulated collagen

Sahrapeyma

Asefnejad

Azami

et al. 2021

J of Applied Polymer Sci

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“…The average VAS score preoperatively was 4.9 (3-7), and it improved to 0.55 (0-2), including the patient with subluxation, the difference was statistically significant (Wilcoxon test, median = −6, P < 0.001). The average CMS preoperatively was 32.8 (27)(28)(29)(30)(31)(32)(33)(34)(35)(36), and it improved to 95.5 (92-99), the difference was statistically significant (t = 60.5, P < 0.001).…”

Section: Resultsmentioning

confidence: 95%

“…The advantages and limitations of the technique are provided (Table 3). In the future, we can use biological composite material instead of titanium cable to reconstruct coracoclavicular ligament, which is more in line with the biomechanics of coracoclavicular ligament [27].…”

Section: Discussionmentioning

confidence: 99%

Acute high-grade acromioclavicular joint dislocation patients treated with titanium cable insertion under a homemade guider

et al. 2021

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Backgrounds To describe a new technique for implanting a double-bundle titanium cable to treat acromioclavicular (AC) joint dislocation via the new guider, and evaluate clinic outcomes. Methods A retrospective study of patients treated for acute high-grade acromioclavicular joint dislocation from June 2016 to January 2020 in our trauma center, twenty patients with AC joint dislocation were managed with double-bundle titanium cable. It includes the following steps: (1) Put the guider under the coracoid close to the cortical; (2) drill proximal clavicle; (3) place the titanium cable; (4) perforate distal clavicle, (5) reset the acromioclavicular joint and lock titanium cable; and (6) suture the acromioclavicular ligament. An independent reviewer conducted functional testing of these patients, including the use of coracoclavicular distance (CCD), visual analog scale (VAS) scores, and Constant–Murley scores (CMS). Results All patients are presented following at a median duration of 15 months (12-24months) after the surgery. All patients based on X-ray evaluation and clinic evaluation. The median CCD was 7.5 (6–14) mm, the VAS score was 0.55 (0-2), the CMS score was 95.5 (92-99). One patient had subluxation again at the final follow-up based on X-ray examination. Conclusions This study demonstrates that the AC joint fixation anatomically with double-bundle titanium, acquired excellent outcomes in terms of the recovery of shoulder joint function and radiographic outcomes. It has a low complication rate and need not remove the hardware.

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“…84 The growth of apatite from SBF can be understood from a series of mechanisms put forward by various researchers. 89,91,92 The isoelectric point of HAP lies between 5 -7, much lower than the SBF (buffered at 7.4). 93 When synthetic HAP compact discs are incubated in SBF, it exposes the negatively charged OH − and (PO 4 ) 3 − ions in its crystal structure, which tends to impart an overall negative charge on the surface (measurements of zeta potential of selected specimens have shown negative charge and have been included in section F (protein adsorption)).…”

Section: In Vitro Bone-like Apatite Formationmentioning

confidence: 97%

“…76 Based on such evidence, the apatite nucleation ability of the specimens is studied. Following incubation, the specimens are washed thoroughly in deionized water to dissolve the nucleated salts [86][87][88][89] and ensure that the deposited layers on the discs are composed entirely of bonelike apatite. SBF solution triggers the deposition of layers of bone-like apatite on the surface of incubated specimens.…”

Section: In Vitro Bone-like Apatite Formationmentioning

confidence: 99%

Physical, chemical, and biological investigations of composites for biomedical applications

et al. 2021

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In this article, the interplay between structural, electrical, and surface properties in determining the collective behavior of Ca 10 (PO 4 ) 6 (OH) 2 (hydroxyapatite, HAP) and SrTiO 3 (strontium titanate, ST) composites was reported. The monoliths HAP and ST were synthesized using sol-gel and solid-state reaction, respectively, and were mixed in different atomic concentrations (20,40,60, and 80 at.%) to prepare a series of composites. The prepared composites were then subjected to x-ray diffraction (XRD) and Raman analysis for probing the microstructural aspects. The analysis revealed no evidence of a phase that the reaction between the two monoliths might form. The crystallite sizes were in the range of 27.2-37.3 nm, and it increased with the content of ST in the composites. The Raman analysis revealed the presence of rutile TiO 2 that was later found to be the link in the display of bone-like apatite nucleation ability in the monolith ST and its composites. The FESEM analysis revealed that the grain sizes were 64-144 nm between the monoliths and were found to follow a similar trend to the crystallite size. The dielectric constant ( r ) varied with temperature ranging from 5 to 35 (1 MHz) at 310 K for all the specimens. The dependence of r on the grain size of the composites followed a nearly exponential relation. The bone-like apatite forming ability of the composites was studied by incubating the specimens in simulated body fluid (SBF). Additionally, the cytocompatibility (MG63 cell lines) and protein adsorption (bovine serum albumin [BSA]) of the selected specimens were also studied to comprehensively understand the delicate relationship between the electrical and biological properties. The protein adsorption was primarily related to the surface charge, and its dependence was found to be linear. Additionally, the r of the composites was ≤35, which compliments the protein adsorption behavior of the specimens.The amount of adsorbed protein for all the specimens considered in this study was in the range of 3-32 μ g/ml. Furthermore, the specimens exhibited excellent cell viability of more than 90%. Based on the physical and biological investigations, 20H-80S was established as the best specimen that blends the characteristic feature of both the monoliths. Finally, the TEM and STEM mapping of the best specimen, projecting the suitability of 20H-80S in the design of electrically active scaffolds and possibly bioelectrets for biomedical applications, was also studied.

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Synergic Effects of Magnetic Nanoparticles on Hyperthermia-Based Therapy and Controlled Drug Delivery for Bone Substitute Application

Cited by 39 publications

References 57 publications

Fabrication of fibrous poly (ɛ‐caprolactone) nano‐fibers containing cerium doped‐bioglasses nanoparticles encapsulated collagen

Fabrication of fibrous poly (ɛ‐caprolactone) nano‐fibers containing cerium doped‐bioglasses nanoparticles encapsulated collagen

Acute high-grade acromioclavicular joint dislocation patients treated with titanium cable insertion under a homemade guider

Physical, chemical, and biological investigations of composites for biomedical applications

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