Synergic effects of aerobic exercise and eugenol supplement on germ cell development and testicular tissue structure in chlorpyrifos-treated animal model

Nikbin, Sina; Derakhshideh, Armin; Tarighe, Mahsa Hozouri; Khojasteh, Zohreh; Kanozi, Foad; Mousavi, Niloufar; Afshar, Tayebeh; Karami, M.; Zolfaghari, Fatemeh; Azarbayjani, Mohammad Ali

doi:10.1007/s11356-020-08222-4

Cited by 9 publications

(1 citation statement)

References 46 publications

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“…Nikbin et al in 2020, in their study, showed that eugenol supplements when given with exercise training work by improving the destructive effects of CPF (chlorpyrifos) on testicular tissue at the cellular level, by enhancing PLZF (promyelocytic leukemia zinc finger) and IGF α (insulin-like growth factor α ). This improves the anatomy of the testis, thereby increasing spermatogenesis in males [ 101 ].…”

Section: Mechanism Of Action Of Selected Plant Constituents For Treat...mentioning

confidence: 99%

Phytochemicals: Alternative for Infertility Treatment and Associated Conditions

Chorosho,

Malik,

Panesar

et al. 2023

Oxidative Medicine and Cellular Longevity

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Infertility and obstetric complications have become global health issues in the past few years. Infertility is defined as the inability of a couple to conceive even after twelve months or more of regular and unprotected intercourse. According to WHO data published in the year 2020, 186 million people have infertility globally. Factors leading to infertility are variable in both males and females. But some common factors include smoking, alcohol consumption, obesity, and stress. Various synthetic drugs and treatment options are available that are effective in treating infertility, but their prolonged usage produces various unwanted adverse effects like hot flashes, mood swings, headaches, and weight gain. In extreme cases, these may also lead to the development of anxiety and depression. Herbal remedies have gained a lot of popularity over the years, and people’s inclination toward them has increased all over the world. The prime reason is that these show significant therapeutic efficacy and have fewer side effects. The therapeutic efficacy of plants can be attributed to the presence of diverse phytochemical classes of constituents like alkaloids, flavonoids, and volatile oils. These secondary metabolites, or phytomolecules, can be used to develop herbal formulations. The review highlights the applications and mechanisms of action of various phytochemicals for treating infertility. Also, it focuses on the various future prospects associated with it.

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Section: Mechanism Of Action Of Selected Plant Constituents For Treat...mentioning

confidence: 99%