Synchronous benign Brenner's tumor of ovary with leiomyoma and endometrial adenocarcinoma in a postmenopausal female

Gaur, Jyotsana Harit; Hassan, Mohammad Jaseem; Elahi, Arifa Anwar; Khetrapal, Shaan; Khan, Sabina; Jetley, Sujata

doi:10.4103/jcrt.jcrt_109_18

Cited by 5 publications

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“…Neoplaziniai dariniai kiaušidėse yra dažna patologija, kuri sudaro apie 30 proc. visų navikinių darinių moters lytiniuose takuose [5]. Brenerio navikas yra retas ir sudaro tik 2 proc.…”

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“…Mikroskopiškai Brenerio navikas susidaro iš gerai ribotų epitelio ląstelių lizdelių, apsuptų tankia fibrozine stroma. Epitelio ląstelės turi būdingą kavos pupelės formos branduolį su išilginiais grioveliais ir jį supančią blyškią citoplazmą [4,5]. Šio naviko epitelio ląstelės yra panašios į urotelio ląsteles, todėl PSO šį naviką priskiria pereinamojo epitelio navikų tipui [5].…”

Section: Diskusijaunclassified

“…Epitelio ląstelės turi būdingą kavos pupelės formos branduolį su išilginiais grioveliais ir jį supančią blyškią citoplazmą [4,5]. Šio naviko epitelio ląstelės yra panašios į urotelio ląsteles, todėl PSO šį naviką priskiria pereinamojo epitelio navikų tipui [5]. Gali būti matomi ryškūs kalcifikatai [4].…”

Section: Diskusijaunclassified

“…Kompiuterinės tomografijos vaizduose matomas kaip nedidelis, solidinis tumoras, gali būti tiek homogeniškos, tiek nehomogeniškos struktūros [5,9]. Dažnai gali būti matomi ir dauginiai kalcifikacijos židinukai solidiniame naviko plote [5]. Brenerio navikas gali turėti ir kitų tipų navikų komponentų, dažniausiai kiaušidžių cistadenomos [9,10].…”

Section: Diskusijaunclassified

“…Brenerio navikas gali turėti ir kitų tipų navikų komponentų, dažniausiai kiaušidžių cistadenomos [9,10]. Tokiais atvejais gali būti matomas kaip solidinis -cistinis tumoras arba cistinis tumoras su dauginiais kalcifikacijos židinėliais [5,9].…”

Section: Diskusijaunclassified

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Brenerio Naviko Radiologinės Diagnostikos Ypatumai. Klinikinis Atvejis

Pavilionė¹,

Dobrovaitė²,

Klimaitė³

2021

Health Sciences

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Brenerio navikas priskiriamas epitelinių kiaušidžių navikų grupei. Dažniausiai tai gerybinis navikas, įprastai randamas atsitiktinai, itin retais atvejais gali būti randamos ir piktybinės jo formos. Brenerio naviko dažnai nepavyksta diferencijuoti nuo kitų kiaušidžių neoplastinių darinių, remiantis vien klinikiniais ir radiologiniais tyrimais – diagnozei patikslinti reikalingas histologinis tyrimas. Pagrindinis šio naviko gydymas yra chirurginis, todėl labai svarbi priešoperacinė diagnozė, kuri lemia operacijos radikalumą. Šiuo klinikiniu atveju Brenerio navikas rastas magnetinio rezonanso metu ir diagnozė patikslinta histologiniu tyrimu.

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Brenerio Naviko Radiologinės Diagnostikos Ypatumai. Klinikinis Atvejis

Pavilionė¹,

Dobrovaitė²,

Klimaitė³

2021

Health Sciences

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Rare case of coexisting ovarian Brenner tumour and ovarian stromal hyperplasia presenting with persistent endometrial hyperplasia following treatment with levonorgestrel-intrauterine system

Mok

Chin

2022

BMJ Case Rep

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Endometrial hyperplasia (EH) is a precursor of endometrial cancer. It arises in an environment of unopposed oestrogen. Treatment is based on a combination of weight management, diet and exercise, and the use of progestogens either via a levonogestrel-intrauterine system (LNG-IUS) or orally. The LNG-IUS is the first-line recommendation for EH without atypia. Recurrences are rare, and any recurrences despite prolonged treatment and control of risk factors necessitate a thorough consideration of other oestrogenic sources. This case report presents a rare case of a coexisting ovarian Brenner tumour and ovarian stromal hyperplasia in a menopausal patient in her 50s with recurrent EH despite earlier regression. The above histology may have provided the additional oestrogenic influence. This patient subsequently underwent a definitive hysterectomy and bilateral salpingo-oophorectomy (BSO). It is important to maintain a high index of suspicion for potential oestrogenic influences in cases of refractory EH that are not identifiable on imaging. BSO should be considered at the time of hysterectomy in such cases of unidentified oestrogenic foci.

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Clinicopathological spectrum of ovarian neoplasms in pre and post menopausal Indian women

Bobde

Kawthalkar²,

Kumbhalkar³

2022

ACHR

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Ovarian cancers are the third most common cancers in women trailing behind cervical and breast cancer. Various molecular insults are seen in hereditary cancer syndromes that results in different morphological types of ovarian cancer.Accurate histological typing suggests screening of the first degree relatives and also targeted therapy for the same. Age specific incidence rate showed that ovarian cancer increases from 35 years of age and peaks between 55 to 64 years of age. Present study was conducted to know the clinical and histopathological spectrum of ovarian neoplasms. To correlate the histopathological subtype with the pre and post menopausal age group. This is a retrospective observational study of 196 cases found over 2.5 years during January 2018 to June 2020. Surface epithelial tumors(SET) are commonest in our study (benign 50%, borderline 6% and malignant 17%) followed by germ cell tumors (12%), sex cord stromal tumors (9%), secondary tumors (5%) and mixed epithelial and mesenchymal tumor (0.5%). Benign SET and germ cell tumors are significantly associated with premenopausal age whereas malignant SET has significant association with post menopausal age. However sex cord stromal tumors did not show any significant association with both the groups. Bilateral involvement was commonest with secondary tumors followed by malignant SET. Mean age of presentation was 41 years with maximum cases presenting in 4 and 5 decade. Various histomorphological parameters were evaluated in detail along with immunohistochemistry(IHC). Inhibin negativity helped to differentiate sertoliform variant of endometrial carcinoma from sertoli cell tumor. WT1 positivity in serous carcinoma ruled out poorly differentiated endometrioid carcinoma in two cases. Thirteen cases show extraovarian spread. Synchronous neoplasms of female genital tract (fibroma with uterine endometrial carcinoma and Brenner with basaloid carcinoma cervix ) were found. Collision tumors (sex cord stromal tumors with germ cell tumors) were also found in present study. Using WHO classification, ovarian tumors can be precisely subcategorized into different morphological subtypes. However overlapping features may need IHC to pinpoint the correct diagnosis. Age specific occurrence of different morphological subtypes may suggest other ancillary investigations and different treatment modalities

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Synchronous benign Brenner's tumor of ovary with leiomyoma and endometrial adenocarcinoma in a postmenopausal female

Cited by 5 publications

References 0 publications

Brenerio Naviko Radiologinės Diagnostikos Ypatumai. Klinikinis Atvejis

Brenerio Naviko Radiologinės Diagnostikos Ypatumai. Klinikinis Atvejis

Rare case of coexisting ovarian Brenner tumour and ovarian stromal hyperplasia presenting with persistent endometrial hyperplasia following treatment with levonorgestrel-intrauterine system

Clinicopathological spectrum of ovarian neoplasms in pre and post menopausal Indian women

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