Symptoms of Obstructive Sleep Apnea, Nasal Obstruction, and Enuresis in Children With Nonsyndromic Cleft Lip and Palate: A Prevalence Study

Fernandes, Marilyse de Bragança Lopes; Salgueiro, Alícia Graziela Noronha Silva; Bighetti, Eliete Janaína Bueno; Trindade‐Suedam, Ivy Kiemle; Trindade, Inge Elly Kiemle

doi:10.1177/1055665618776074

Cited by 15 publications

(30 citation statements)

References 62 publications

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“…Nasal congestion is considered to be a major factor interfering with sleep quality and inducing daytime somnolence. Previous studies suggest that nasal obstruction contributes to higher risks of OSA [48][49][50] and SDB [51,52]. The role of nasal congestion as a risk factor for snoring has also been confirmed by a population-based cohort study [53].…”

Section: Assessment Of Cumulative Evidencementioning

confidence: 70%

The association between allergic rhinitis and sleep: A systematic review and meta-analysis of observational studies

et al. 2020

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This systematic review and meta-analysis examines the associations of allergic rhinitis with sleep duration and sleep impairment. Observational studies published before August 2019 were obtained through English language literature searches in the PubMed, Embase, and CINAHL databases. Mean differences and odds ratios with 95% confidence intervals were extracted and used for meta-analysis. Heterogeneity was confirmed by the I 2-heterogeneity test. Subgroup analysis was conducted to evaluate the influence of study design. The Grading of Recommendations Assessment, Development, and Evaluation approach was used to determine the level of evidence. In total, 2544 records were identified through database searches; 914 duplicate records were excluded, 1452 records were removed after screening of titles and abstracts, 151 records were excluded after full-text screening, and 27 articles were included in the final meta-analyses. A total of 240,706,026 patients (19,444,043 with allergic rhinitis) were considered. No significant difference in sleep duration between the allergic rhinitis and the control groups was found. Patients with allergic rhinitis presented with significantly higher sleep quality scores, sleep disturbances scores, and sleep latency scores; more frequent use of sleep medications; and lower sleep efficiency as measured by the Pittsburgh Sleep Quality Index and polysomnography. Meta-analyses for adjusted odds ratios showed that allergic rhinitis was also associated with higher risks of nocturnal dysfunctions, including insomnia, nocturnal enuresis, restless sleep, sleep-disordered breathing, obstructive sleep apnea, and snoring. Meta-analysis for adjusted odds ratio also showed that allergic rhinitis was associated with daytime dysfunction, including difficulty waking up, daytime sleepiness, morning headache, and the use of sleep medications. The overall quality of evidence ranged from low to very low, indicating that caution is required when interpreting these results. This study demonstrates that there is a significant association of AR with sleep characteristics.

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Section: Assessment Of Cumulative Evidencementioning

confidence: 70%

The association between allergic rhinitis and sleep: A systematic review and meta-analysis of observational studies

et al. 2020

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“…According to the American Academy of Otolaryngology–Head and Neck Surgery (AAO–HNS), polysomnography is the gold standard for diagnosing sleep‐disordered breathing in children, including OSA. 23 Polysomnography is recommended before tonsillectomy in children with SDB who have conditions that increase their risk for complications of surgery, such as obesity, Down syndrome, 23 , 24 craniofacial abnormalities (eg, Pierre‐Robin sequence and cleft palate), 23 , 25 , 26 neuromuscular disorders (eg, muscular dystrophy), sickle cell disease (SCD), or mucopolysaccharidoses. 23 Children with Down syndrome have adenotonsillar hypertrophy, midface and mandibular hypoplasia, relative macroglossia, glossoptosis, generalized muscular hypotonia, and obesity, increasing their risk for airway obstruction.…”

Section: Diagnostic Evaluation Of Sdb and Osa Syndromementioning

confidence: 99%

Sleep‐Disordered Breathing and Cardiovascular Disease in Children and Adolescents

Smith¹,

Isaiah²,

Melendres³

et al. 2021

JAHA

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Obstructive sleep apnea (OSA) is a known risk factor for cardiovascular disease in adults. It is associated with incident systemic hypertension, arrhythmia, stroke, coronary artery disease, and heart failure. OSA is common in children and adolescents, but there has been less focus on OSA as a primary risk factor for cardiovascular disease in children and adolescents. This scientific statement summarizes what is known regarding the impact of sleep‐disordered breathing and, in particular, OSA on the cardiovascular health of children and adolescents. This statement highlights what is known regarding the impact of OSA on the risk for hypertension, arrhythmia, abnormal ventricular morphology, impaired ventricular contractility, and elevated right heart pressure among children and adolescents. This scientific statement also summarizes current best practices for the diagnosis and evaluation of cardiovascular disease–related complications of OSA in children and adolescents with sleep apnea and highlights potential future research in the area of sleep‐disordered breathing and cardiovascular health during childhood and adolescence.

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“…Several studies have indicated an association between nasal obstruction and increased risk of RSD, with a prevalence of this symptom being observed in up to 50% of non-syndromic patients diagnosed with OSA. 9 , 10 , 11 , 12 It is speculated that the airflow decreases during sleep, due to nasal pathologies, generates progressive negative pressures in the upper airways (UA), facilitating pharyngeal collapse, and, consequently, snoring, obstructive apnea, sleep fragmentation and excessive daytime sleepiness. 10 The relationship between the nasal obstruction intensity and greater severity and occurrence of OSA, however, remains controversial.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, patients with PRS show morphological alterations that increase the risk of OSA at different stages of life. 11 , 15 Moreover, it should be noted that the primary corrective surgery of the palate may further compromise the nasal and pharyngeal dimensions, generating a higher risk for RSD in this population. 6 , 11 , 16 , 17 …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Respiratory sleep disorders, nasal obstruction and enuresis in children with non-syndromic Pierre Robin sequence

Banhara¹,

Trindade²,

Trindade‐Suedam³

et al. 2022

Brazilian Journal of Otorhinolaryngology

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Symptoms of Obstructive Sleep Apnea, Nasal Obstruction, and Enuresis in Children With Nonsyndromic Cleft Lip and Palate: A Prevalence Study

Abstract: Children with nonsyndromic cleft lip and palate have high prevalence of nasal obstruction and enuresis and are at risk of OSA.

Cited by 15 publications

References 62 publications

The association between allergic rhinitis and sleep: A systematic review and meta-analysis of observational studies

The association between allergic rhinitis and sleep: A systematic review and meta-analysis of observational studies

Sleep‐Disordered Breathing and Cardiovascular Disease in Children and Adolescents

Respiratory sleep disorders, nasal obstruction and enuresis in children with non-syndromic Pierre Robin sequence

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