Swimming reduces fatty acids-associated hypothalamic damage in mice

Nogueira, Pedro Augusto Silva; Pereira, Miriam Pimenta; Soares, Jeferson José Gomes; Gomes, Juliana de Assis Silva; Ribeiro, Daniele Lisboa; Razolli, Daniela S.; Velloso, Lı́cio A.; Neto, Morun Bernardino; Zanon, Renata Graciele

doi:10.1016/j.jchemneu.2019.101713

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…Microglial activation induced interleukin-1 and TNF-α expression, then activated A1-reactive astrocytes and released neurotoxins and cytokines to promote apoptosis of neurons and oligodendrocytes [18,20,42]. Nogueira et al showed that swimming could protect the synapses and reduce astrogliosis in the hypothalamus of high-fat diet animals [43]. We confirmed that the overexpression of TNF-α, IL-1β, MMP-2 and MMP-9 induced by high-fat diet in the hypothalamus could be suppressed by swimming exercise and diet control.…”

Section: Discussionmentioning

confidence: 99%

The effect of swimming exercise and diet on the hypothalamic inflammation of ApoE-/- mice based on SIRT1-NF-κB-GnRH expression

Wang

Yang

et al. 2020

Aging

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A high-fat diet and sedentary lifestyle could accelerate aging and hypothalamic inflammation. In order to explore the regulatory mechanisms of lifestyle in the hypothalamus, swimming exercise and diet control were applied in the high-fat diet ApoE-/-mice in our study. 20-week-old ApoE-/-mice fed with 12-week high-fat diet were treated by high-fat diet, diet control and swimming exercise. The results showed that hypothalamic inflammation, glial cells activation and cognition decline were induced by high-fat diet. Compared with the diet control, hypothalamic inflammation, glial cells activation and learning and memory impairment were effectively alleviated by swimming exercise plus diet control, which was related to the increasing expression of SIRT1, inhibiting the expression of NF-κB and raising secretion of GnRH in the hypothalamus. These findings supported the hypothesis that hypothalamic inflammation was susceptible to exercise and diet, which was strongly associated with SIRT1-NF-κB-GnRH expression in the hypothalamus.

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Section: Discussionmentioning

confidence: 99%

The effect of swimming exercise and diet on the hypothalamic inflammation of ApoE-/- mice based on SIRT1-NF-κB-GnRH expression

Wang

Yang

et al. 2020

Aging

View full text Add to dashboard Cite

show abstract

“…Loss or inhibition of TLR4 or myeloid differentiation primary response 88 in the hypothalamus restores energy homeostasis in rodents exposing high-fat diet (HFD) ( 37 , 42 , 43 ). Inhibition of TLR4-induced inflammation has been reported to reduce fatty acid-induced hypothalamic inflammation and hypothalamic injury ( 44 ). Knockdown of TLR4 in ARH protects obese rats from diet-induced weight gain, and energy intake has been demonstrated ( 35 ).…”

mentioning

confidence: 99%