Swietenine: A potential oral hypoglycemic from Swietenia macrophylla seed

Dewanjee, Saikat; Maiti, Anup; Das, Anup Kumar; Mandal, Subhash C.; Dey, Sourav

doi:10.1016/j.fitote.2009.02.004

Cited by 49 publications

(40 citation statements)

References 6 publications

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“…Unique to the AA extracts, swietenine was also detected in this study. Swietenine found in the seed of the sky fruit, Swietenia macrophylla, has been reported to display anti-inflammatory, anti-mutagenicity, and antitumor activities (Dewanjee et al, 2009). Our study also detected tyrosol, or 4-hydroxyphenylethanol, in the PS extract.…”

Section: Discussionsupporting

confidence: 59%

Antioxidant activity, anti-proliferative activity, and amino acid profiles of ethanolic extracts of edible mushrooms

2016

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ABSTRACT. Biological activities of various mushrooms have recently been discovered, particularly, immunomodulatory and antitumor activities. Herein, three edible mushrooms, Auricularia auricula-judae (AA), Pleurotus abalonus (PA) and Pleurotus sajor-caju (PS) extracted using Soxhlet ethanol extraction were evaluated for their antioxidative, anti-proliferative effects on leukemia cells. Using the Folin-Ciocalteau method and Trolox equivalent antioxidant capacity assay, phenolics and antioxidant activity were found in all sample mushrooms. Additionally, anti-proliferative activity of mushroom extracts against U937 leukemia cells was determined using a viability assay based on mitochondrial activity. PA (0.5 mg/mL) and AA (0.25-0.5 mg/mL) significantly reduced cell viability. Interestingly, PS caused a hormeticlike biphasic dose-response. Low doses (0-0.25 mg/L) of PS promoted cell proliferation up to 140% relative to control, whereas higher doses (0.50 mg/mL) inhibited cell proliferation. Against U937 cells, AA IC 50 was 0.28 ± 0.04 mg/mL, which was lower than PS or PA IC 50 (0.45 ± 0.01 and 0.49 ± 0.001 mg/mL, respectively). Furthermore, lactate dehydrogenase (LDH) leakage conferred cytotoxicity. PS and PA were not toxic to U937 cells at any tested concentration; AA (0.50 mg/mL) showed high LDH levels and caused 50% cytotoxicity. Additionally, UPLC-HRMS data indicated several phytochemicals known to support functional activities as either antioxidant or anti-proliferative. Glutamic acid was uniquely found in ethanolic extracts of AA, and was considered an anti-cancer amino acid with potent anti-proliferative effects on U937 cells. Collectively, all mushroom extracts exhibited antioxidant effects, but their anti-proliferative effects were dose-dependent. Nevertheless, the AA extract, with highest potency, is a promising candidate for future applications.

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Section: Discussionsupporting

confidence: 59%

Antioxidant activity, anti-proliferative activity, and amino acid profiles of ethanolic extracts of edible mushrooms

2016

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“…Chemical profiling of the Swietenia macrophylla extract used in this present study reveals the putative presence of 3,6-di-O-acetylswietenolide and other limonoids (Fowles et al, 2007). Elsewhere, numerous studies have reported anti inflammatory, anti malaria and anti diabetic properties of Swietenia macrophylla limonoids (Dewanjee et al, 2009;Chen et al, 2010).…”

Section: Discussionmentioning

confidence: 57%

Swietenia macrophylla extract promotes the ability of Caenorhabditis elegans to survive Pseudomonas aeruginosa infection

Dharmalingam

Tan

Mahmud

et al. 2012

Journal of Ethnopharmacology

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“…There are two main forms of diabetes namely type 1 and type 2. Among them later is more prevalent and account for about 90% to 95% of all diagnosed cases of diabetes [2]. According to the hottest postulation, the global population is approaching to the diabetes endemic.…”

Section: Introductionmentioning

confidence: 99%

Rohu Fish (Labio Rohita) Bile Attenuates Streptozotocin- Induced Diabetes Mellitus in Rats: Evidence from Biochemical and Oxidative Stress Markers

Pottoo¹

2017

Austin J Pharmacol Ther

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Aim: Present study was undertaken to validate folklore claims regarding antidiabetic activity of the bile of 'Rohu' (Labeo rohita) fish.Method: Diabetes was induced by single injection of Streptozotocin (50 mg/ kg) in Wistar rats. Diabetic rats were screened and treated with bile (0.08 and 0.16 ml/kg, p.o) daily for 14 days. Fasting blood glucose level was estimated at specific intervals. Serum lipid profiles, serum biochemical parameters related to diabetic pathophysiology and hepatic redox makers were estimated.Result: Oral administration of bile to diabetic rats caused significant and dose dependant hypoglycaemic activity with a maximum reduction of blood glucose level (~77 %, p < 0.001) on day 15 at the dose of 0.16ml/kg. Bile treatment also could significantly (p < 0.001) control hyperlipidemia and restore serum biochemical parameters near to normal values. Diabetic control rats showed a significant (p < 0.001) rise in lipid peroxidation and depletion (p < 0.001) of antioxidant enzymes in hepatic tissue of diabetic rats as compared with normal rats. Bile treatment, however, could significantly (p < 0.05-0.01) revert these changes near to the normal status. Conclusion:The Labeo rohita fish bile is capable of managing hyperglycaemia, hyperlipidemia and associated complications in diabetes.

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Swietenine: A potential oral hypoglycemic from Swietenia macrophylla seed

Cited by 49 publications

References 6 publications

Antioxidant activity, anti-proliferative activity, and amino acid profiles of ethanolic extracts of edible mushrooms

Antioxidant activity, anti-proliferative activity, and amino acid profiles of ethanolic extracts of edible mushrooms

Swietenia macrophylla extract promotes the ability of Caenorhabditis elegans to survive Pseudomonas aeruginosa infection

Rohu Fish (Labio Rohita) Bile Attenuates Streptozotocin- Induced Diabetes Mellitus in Rats: Evidence from Biochemical and Oxidative Stress Markers

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