Purpose: To perform a quantitative analysis of choriocapillaris (CC) flow deficits (FDs) in patients with uveitis.
Design: Retrospective cross-sectional studyMethods: Swept-source optical coherence tomography based angiography (SS-OCTA) macular volume scans (3×3 mm and 6×6 mm) were obtained using the PLEX® Elite 9000: En face CC images were generated and analyzed using an automated flow deficit identification algorithm. Three quantitative metrics were determined for each eye: FD number (FDN), mean FD size (MFDS), and FD density (FDD). Quantitative metrics were compared between uveitis and control eyes. The uveitis cohort was further subdivided by the presence or absence of choroidal involvement, and quantitative metrics were compared between subgroups and normal controls Results: A total of 38 eyes from 38 controls and 73 eyes from 73 uveitis subjects were included in this study. Eyes with uveitis have significantly larger CC MFDS (3×3 mm, p<0.0001; 6×6 mm, p<0.0001) and higher FDD (p=0.0002; p=0.0076) when compared to control eyes. Additional analysis determined that these differences are due to the choroidal disease subgroup, which demonstrates significantly larger MFDS (3×3 =1108 μm 2 ; 6×6 =1104 μm 2 ) compared to both normal controls (752 μm 2 , p<0.0001; 802 μm 2 , p<0.0001) and uveitis patients without choroidal involvement (785 μm 2 , p<0.0001; 821 μm 2 , p<0.0001). No significant differences were found between the quantitative metrics of controls and patients without choroidal involvement.Conclusions: Automated quantification of CC can identify pathological FDs and provide quantitative metrics describing such lesions in patients with uveitis. Posterior uveitis patients have significantly larger CC FDs than patients with other forms of uveitis.