Swelling Behaviors of 3D Printed Hydrogel and Hydrogel-Microcarrier Composite Scaffolds

Bittner, Sean M.; Pearce, Hannah A.; Hogan, Katie; Smoak, Mollie M.; Guo, Jason; Melchiorri, Anthony J.; Scott, David W.; Mikos, Antonios G.

doi:10.1089/ten.tea.2020.0377

Cited by 20 publications

(13 citation statements)

References 42 publications

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“…Various secondary components such as interpenetrating (IPN) hydrogels, nanomaterials, and microcarriers, along with living cells, can be incorporated with GelMA hydrogels to tailor specific physical and biological requirements for tissue bioprinting. 30,[42][43][44] Ceramic nanoparticles such as bioactive glass and calcium phosphate-incorporated hybrid bioinks have been used to mimic the natural ECM of bone tissue via 3D bioprinting. 25,45 3.1 HAp nanopowders synthesized without the use of surfactant…”

Section: Resultsmentioning

confidence: 99%

Extrusion‐based 3D printing of gelatin methacryloyl with nanocrystalline hydroxyapatite

Das

Basu

2021

Int J Applied Ceramic Tech

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The particle shape and size distribution of inorganic fillers play a crucial role in the scaffold buildability when those are incorporated in the viscoelastic polymers. In order to address this issue, the phase pure rod-shaped nanocrystalline hydroxyapatite (HAp) powders with varying particle sizes and shapes were synthesized by a one-pot hydrothermal method without any regulatory surfactant at an initial solution pH of 9. As-synthesized nanocrystalline HAp particles (0-5 wt%) were incorporated into 15 wt% pre-cross-linked gelatin methacryloyl (GelMA) hydrogel matrix to fabricate a predesigned scaffold architecture using a custom-made 3D bioprinter. The printing parameters (nozzle diameter, extrusion pressure, and printing speed) were optimized for each composition. The biophysical properties (uniaxial compression behavior, swelling ratio, and in vitro degradation) of the composite hydrogel scaffolds were critically analyzed to unravel the role of nano-sized HAp addition. The compression strength and modulus were substantially improved, while the rate of water uptake and bioenzymatic degradation significantly reduced with HAp content. We propose that the inorganic-organic nanocomposite hydrogel could be efficiently assembled to formulate a potential bioink for 3D bioprinting applications toward tissue regeneration.

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Section: Resultsmentioning

confidence: 99%

Extrusion‐based 3D printing of gelatin methacryloyl with nanocrystalline hydroxyapatite

Das

Basu

2021

Int J Applied Ceramic Tech

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“…Water uptake and swelling ability of hydrogel are important, since they impact nutrient transport, shape retention and evaluation of the affinity of biofabricated 3D constructs with adjacent tissues. 45 SilMA-PEGDA printed hydrogel constructs indicated excellent swelling properties with swelling ratio~8 times than original weight with maintained 3D structure. Higher equilibrium swelling ratio provides benefit in terms of more space for cell growth, migration withing the printed construct in cell-laden printing.…”

Section: Immunohistochemical and Histological Evaluation Of Constructsmentioning

confidence: 97%

3D bioprinting of photo‐crosslinkable silk methacrylate (SilMA)‐polyethylene glycol diacrylate (PEGDA) bioink for cartilage tissue engineering

Bandyopadhyay

Mandal

Bhardwaj

2021

J Biomedical Materials Res

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Articular cartilage damage poses huge burden on healthcare sector globally due to its extremely weak inherent regenerative ability. Three-dimensional (3D) bioprinting for development of cartilage mimic constructs using composite bioinks serves as an emerging perspective. However, difficulty in development of suitable bioink and chemical crosslinking associated inherent toxicity hamper widespread adoption of this technique. To circumvent this, a photo-polymerizable hydrogel-based bioink

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“…Therefore, gelatin is often used in biomedical fields, such as in the production of drug capsules. In particular, gelatin is used in microparticles and microspheres to provide the controlled release of drugs [ 168 , 169 ]. In the 1960s, Tanaka et al.…”

Section: Microsphere Processing Materialsmentioning

confidence: 99%

Progress in the application of sustained-release drug microspheres in tissue engineering

Ruan¹,

Su²,

Qin³

et al. 2022

Materials Today Bio

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Swelling Behaviors of 3D Printed Hydrogel and Hydrogel-Microcarrier Composite Scaffolds

Cited by 20 publications

References 42 publications

Extrusion‐based 3D printing of gelatin methacryloyl with nanocrystalline hydroxyapatite

Extrusion‐based 3D printing of gelatin methacryloyl with nanocrystalline hydroxyapatite

3D bioprinting of photo‐crosslinkable silk methacrylate (SilMA)‐polyethylene glycol diacrylate (PEGDA) bioink for cartilage tissue engineering

Progress in the application of sustained-release drug microspheres in tissue engineering

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