Progress in the application of sustained-release drug microspheres in tissue engineering

Ruan, Lian; Su, Mengrong; Qin, Xinyun; Ruan, Qingting; Lang, Wen; Wu, Minhui; Chen, Yujie; Lv, Qizhuang

doi:10.1016/j.mtbio.2022.100394

Cited by 29 publications

(21 citation statements)

References 215 publications

(209 reference statements)

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“…Therefore, the active ingredient can be diffused into the surrounding environment at an optimal release rate within a certain period of time. 40 Though remarkable achievements have been made, it is worth putting in sustained efforts in this area to make the following improvements: (1) simplify the preparation processes of carrier systems, and reduce the preparation costs. The controlled-release system AVM@(CH + SL) n prepared in the current study does not require complex processes, and the preparation conditions, as well as equipment, are quite normal, which enables it to be used at a low cost and on a large scale.…”

Section: Resultsmentioning

confidence: 99%

Dual-responsive microcapsules with tailorable shells from oppositely charged biopolymers for precise pesticide release

Wang

et al. 2023

Mater. Adv.

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Section: Resultsmentioning

confidence: 99%

Dual-responsive microcapsules with tailorable shells from oppositely charged biopolymers for precise pesticide release

Wang

et al. 2023

Mater. Adv.

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“…The structure of the microspheres was then greatly disassembled, causing the drug to undergo secondary release as the hydrogel structure slips [ 43 , 44 ]. Microspheres with sustained release capability are especially suitable for drug delivery in long-term clinical treatment operations to control the release of locally delivered drugs and improve the treatment efficiency [ 45 ]. For example, cartilage regeneration requires more than 30 days of growth factor release to achieve repair [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

In Vitro Characterizations of Post-Crosslinked Gelatin-Based Microspheres Modified by Phosphatidylcholine or Diammonium Phosphate as Antibiotic Delivery Vehicles

Chang

Chen

et al. 2023

Polymers

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Hydrogel-based microspheres prepared by emulsification have been widely used as drug carriers, but biocompatibility remains a challenging issue. In this study, gelatin was used as the water phase, paraffin oil was used as the oil phase, and Span 80 was used as the surfactant. Microspheres were prepared using a water-in-oil (W/O) emulsification. Diammonium phosphate (DAP) or phosphatidylcholine (PC) were further used to improve the biocompatibility of post-crosslinked gelatin microspheres. The biocompatibility of DAP-modified microspheres (0.5–10 wt.%) was better than that of PC (5 wt.%). The microspheres soaked in phosphate-buffered saline (PBS) lasted up to 26 days before fully degrading. Based on microscopic observation, the microspheres were all spherical and hollow inside. The particle size distribution ranged from 19 μm to 22 μm in diameter. The drug release analysis showed that the antibiotic gentamicin loaded on the microspheres was released in a large amount within 2 h of soaking in PBS. It was stabilized until the amount of microspheres integrated was significantly reduced after soaking for 16 days and then released again to form a two-stage drug release curve. In vitro experiments showed that DAP-modified microspheres at concentrations less than 5 wt.% had no cytotoxicity. Antibiotic-impregnated and DAP-modified microspheres had good antibacterial effects against Staphylococcus aureus and Escherichia coli, but these drug-impregnated groups hinder the biocompatibility of hydrogel microspheres. The developed drug carrier can be combined with other biomaterial matrices to form a composite for delivering drugs directly to the affected area in the future to achieve local therapeutic effects and improve the bioavailability of drugs.

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“…Natural material-based hydrogels with better biocompatibility were classified into polysaccharides and proteins. Polysaccharides mainly include chitosan (Chi), alginates (Alg), hyaluronic acid (HA), heparin (Hep), CS, dextran (Dex), 88,[92][93][94] etc. Proteins mainly contain collagen (Col), gelatin (Gel),…”

Section: Hydrogelmentioning

confidence: 99%

Functional biomaterials for osteoarthritis treatment: From research to application

et al. 2022

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Osteoarthritis (OA) is a common disease that endangers millions of middle‐aged and elderly people worldwide. Researchers from different fields have made great efforts and achieved remarkable progress in the pathogenesis and treatment of OA. However, there is still no cure for OA. In this review, we discuss the pathogenesis of OA and summarize the current clinical therapies. Moreover, we introduce various natural and synthetic biomaterials for drug release, cartilage transplantation, and joint lubricant during the OA treatment. We also present our perspectives and insights on OA treatment in the future. We hope that this review will foster communication and collaboration among biological, clinical, and biomaterial researchers, paving the way for OA therapeutic breakthroughs.

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Progress in the application of sustained-release drug microspheres in tissue engineering

Cited by 29 publications

References 215 publications

Dual-responsive microcapsules with tailorable shells from oppositely charged biopolymers for precise pesticide release

Dual-responsive microcapsules with tailorable shells from oppositely charged biopolymers for precise pesticide release

In Vitro Characterizations of Post-Crosslinked Gelatin-Based Microspheres Modified by Phosphatidylcholine or Diammonium Phosphate as Antibiotic Delivery Vehicles

Functional biomaterials for osteoarthritis treatment: From research to application

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