Swedish protons

Goitein, Michael; Goitein, Gudrun

doi:10.1080/02841860500402207

Cited by 12 publications

(3 citation statements)

References 12 publications

(11 reference statements)

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“…However, since improved dose distributions can be achieved by using proton beams instead (Wilson 1946, Lomax et al 1999 the interest for proton therapy has increased. Whether the reduced normal tissue dose and/or the possibility of increasing the target dose, when using proton beams, will result in a clinical advantage or not has been discussed and reviewed by several authors ( Goitein and Goitein 2005, Glimelius and Montelius 2007, Olsen et al 2007, Lodge et al 2007. In Sweden, the discussion if there are a sufficient number of patients who would have a clinical benefit of being treated with protons (Glimelius et al 2005) has led to a proposal to build a Swedish proton therapy facility (SPTC 2003, Karlsson et al 2006.…”

Section: Introductionmentioning

confidence: 99%

Reference dosimetry in a scanned pulsed proton beam using ionisation chambers and a Faraday cup

Lorin¹,

Grusell²,

Tilly³

et al. 2008

Phys. Med. Biol.

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In order to give the correct dose to a patient, the monitor chamber for a proton scanning system has to be calibrated. As recombination of ion pairs occurs in the monitor chamber, the relation between the number of particles traversing it per time unit and the ionization chamber signal is not linear. A method developed for a scanned pulsed proton beam taking the nonlinear monitor signal into account is described. A vital part of the reference dosimetry procedure is to determine the absorbed dose under reference conditions, which is recommended to be done with an ionization chamber. For a scanned pulsed proton beam, the recombination in the ionization chamber is not negligible and the signal from the ionization chamber has to be corrected. In this work, it is shown that although the pulse length is comparable to the ion transit time the beam can be considered as continuously scanned if the applied high voltage is not too small. Also shown is that the two-voltage formula for a continuous beam is under some conditions applicable for a continuous scanned beam as well.

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Section: Introductionmentioning

confidence: 99%

Reference dosimetry in a scanned pulsed proton beam using ionisation chambers and a Faraday cup

Lorin¹,

Grusell²,

Tilly³

et al. 2008

Phys. Med. Biol.

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show abstract

“…Since then, several new similar studies have been published, all with the same result revealing potential superiority of protons relative to intensity-modulated photon radiotherapy (IMRT) [24 Á29]. It was accompanied by two critical editorials [30,31], one with the title 'Swedish protons', pinpointing the lack of solid evidence. It can now be mentioned that the county councils of the seven university hospitals in Sweden in June 2006 decided to invest in a dedicated facility for heavy particle therapy in Uppsala, Sweden.…”

Section: Swedish Protonsmentioning

confidence: 99%

Acta Oncologica – achievements during 2006 and a look at the future

Glimelius¹

2007

Acta Oncologica

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“…To attain these goals new beam delivery techniques such as intensity modulated radiation therapy (IMRT)[ 1 ] or new beam modalities such as proton and heavier ions called hadron therapy were introduced. [ 2 3 4 5 ] The strength of hadron therapy lies in their unique physical and radiobiological properties of these particles. Hadrons can penetrate the tissues with less lateral straggling and deposit the maximum energy just before stopping.…”

Section: Introductionmentioning

confidence: 99%

Comparison of electromagnetic and hadronic models generated using Geant 4 with antiproton dose measured in CERN

et al. 2015

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After proposing the idea of antiproton cancer treatment in 1984 many experiments were launched to investigate different aspects of physical and radiobiological properties of antiproton, which came from its annihilation reactions. One of these experiments has been done at the European Organization for Nuclear Research known as CERN using the antiproton decelerator. The ultimate goal of this experiment was to assess the dosimetric and radiobiological properties of beams of antiprotons in order to estimate the suitability of antiprotons for radiotherapy. One difficulty on this way was the unavailability of antiproton beam in CERN for a long time, so the verification of Monte Carlo codes to simulate antiproton depth dose could be useful. Among available simulation codes, Geant4 provides acceptable flexibility and extensibility, which progressively lead to the development of novel Geant4 applications in research domains, especially modeling the biological effects of ionizing radiation at the sub-cellular scale. In this study, the depth dose corresponding to CERN antiproton beam energy by Geant4 recruiting all the standard physics lists currently available and benchmarked for other use cases were calculated. Overall, none of the standard physics lists was able to draw the antiproton percentage depth dose. Although, with some models our results were promising, the Bragg peak level remained as the point of concern for our study. It is concluded that the Bertini model with high precision neutron tracking (QGSP_BERT_HP) is the best to match the experimental data though it is also the slowest model to simulate events among the physics lists.

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Swedish protons

Cited by 12 publications

References 12 publications

Reference dosimetry in a scanned pulsed proton beam using ionisation chambers and a Faraday cup

Reference dosimetry in a scanned pulsed proton beam using ionisation chambers and a Faraday cup

Acta Oncologica – achievements during 2006 and a look at the future

Comparison of electromagnetic and hadronic models generated using Geant 4 with antiproton dose measured in CERN

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