Swallowing Gel for Patients with Dysphagia: A Novel Application of Chitosan

Sangnim, Tanikan; Sriamornsak, Pornsak; Singh, Inderbir; Huanbutta, Kampanart

doi:10.3390/gels7030108

Cited by 5 publications

(4 citation statements)

References 27 publications

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“…Given the unique properties of sea fennel, its exploitation to produce nutraceuticals with neuroprotective, antioxidant, analgesic, immunomodulatory, antimicrobial, antidiabetic, and cardioprotective properties has previously been proposed [ 11 ]. The administration of a nutraceutical and dietary supplement should be oriented towards advanced dosage forms such as orodispersible tablets, fast-dissolving films, and easy-swallowing gels for difficult-swallowing subjects [ 96 ]. Hence, powders, isolates, and extracts, together with excipients such as gums, chitosan, alginate, and polysaccharides, should be used in the development phase [ 96 ].…”

Section: Exploitation Of Sea Fennel For the Production Of Nutraceuticalsmentioning

confidence: 99%

“…The administration of a nutraceutical and dietary supplement should be oriented towards advanced dosage forms such as orodispersible tablets, fast-dissolving films, and easy-swallowing gels for difficult-swallowing subjects [ 96 ]. Hence, powders, isolates, and extracts, together with excipients such as gums, chitosan, alginate, and polysaccharides, should be used in the development phase [ 96 ].…”

Section: Exploitation Of Sea Fennel For the Production Of Nutraceuticalsmentioning

confidence: 99%

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Sea Fennel (Crithmum maritimum L.) as an Emerging Crop for the Manufacturing of Innovative Foods and Nutraceuticals

Kraouia,

Nartea,

Maoloni

et al. 2023

Molecules

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Sea fennel (Crithmum maritimum L.) is a perennial, strongly aromatic herb that has been used since ancient times in cuisine and folk medicine due to its renowned properties. Recently described as a “cash” crop, sea fennel is an ideal candidate for the promotion of halophyte agriculture in the Mediterranean basin due to its acknowledged adaptation to the Mediterranean climate, its resilience to risks/shocks related to climate changes, and its exploitability in food and non-food applications, which generates an alternative source of employment in rural areas. The present review provides insight into the nutritional and functional traits of this new crop as well as its exploitation in innovative food and nutraceutical applications. Various previous studies have fully demonstrated the high biological and nutritional potential of sea fennel, highlighting its high content of bioactive compounds, including polyphenols, carotenoids, ω-3 and ω-6 essential fatty acids, minerals, vitamins, and essential oils. Moreover, in previous studies, this aromatic halophyte showed good potential for application in the manufacturing of high-value foods, including both fermented and unfermented preserves, sauces, powders, and spices, herbal infusions and decoctions, and even edible films, as well as nutraceuticals. Further research efforts are needed to fully disclose the potential of this halophyte in view of its full exploitation by the food and nutraceutical industries.

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Section: Exploitation Of Sea Fennel For the Production Of Nutraceuticalsmentioning

confidence: 99%

Section: Exploitation Of Sea Fennel For the Production Of Nutraceuticalsmentioning

confidence: 99%

Sea Fennel (Crithmum maritimum L.) as an Emerging Crop for the Manufacturing of Innovative Foods and Nutraceuticals

Kraouia,

Nartea,

Maoloni

et al. 2023

Molecules

View full text Add to dashboard Cite

show abstract

“…This is because this group of people has limitations in solid dosage from (tablets or capsules) swallowing (dysphagia). Therefore, advanced dosage forms such as orodispersible tablets, fast dissolving films and easy-swallowing gels, which are normally used in pharmaceutical applications, have to be considered in nutraceutical and dietary supplement administration [ 141 , 142 , 143 ].…”

Section: Formulations and Challenges Involvedmentioning

confidence: 99%

A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges

et al. 2022

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Nutraceuticals are the nourishing components (hybrid of nutrition and pharmaceuticals) that are biologically active and possess capability for maintaining optimal health and benefits. These products play a significant role in human health care and its endurance, most importantly for the future therapeutic development. Nutraceuticals have received recognition due to their nutritional benefits along with therapeutic effects and safety profile. Nutraceuticals are globally growing in the field of services such as health care promotion, disease reduction, etc. Various drug nutraceutical interactions have also been elaborated with various examples in this review. Several patents on nutraceuticals in agricultural applications and in various diseases have been stated in the last section of review, which confirms the exponential growth of nutraceuticals’ market value. Nutraceuticals have been used not only for nutrition but also as a support therapy for the prevention and treatment of various diseases, such as to reduce side effects of cancer chemotherapy and radiotherapy. Diverse novel nanoformulation approaches tend to overcome challenges involved in formulation development of nutraceuticals. Prior information on various interactions with drugs may help in preventing any deleterious effects of nutraceuticals products. Nanotechnology also leads to the generation of micronized dietary products and other nutraceutical supplements with improved health benefits. In this review article, the latest key findings (clinical studies) on nutraceuticals that show the therapeutic action of nutraceutical’s bioactive molecules on various diseases have also been discussed.

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“…5 Chitosan is a natural biopolymer that can be easily functionalized to obtain the desired targeted results and is also approved by Generally Recognized as Safe (GRAS) and the US Food and Drug Administration (US FDA). [6][7][8][9][10] Moreover, the addition of chitosan can improve the solubility, 11 bioavailability, 12 and mucoadhesive properties 13 of drug delivery systems. Chitosan nanoparticles have been applied in various drug delivery systems, such as colonic drug delivery, 4 nucleic acid drug delivery, 14 ocular drug delivery, 15 peroral delivery, [16][17][18][19][20] pulmonary drug delivery, 21 nasal drug delivery, 22 mucosal drug delivery, 23 gene delivery, 24 vaccine delivery and 25 vaginal drug delivery, 26 as well as for cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

Key Fabrications of Chitosan Nanoparticles for Effective Drug Delivery Using Flow Chemistry Reactors

Huanbutta,

Sriamornsak,

Suwanpitak

et al. 2023

IJN

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Introduction Chitosan nanoparticles have garnered considerable interest in the field of drug delivery owing to their distinctive properties, including biocompatibility, biodegradability, low toxicity, and ability to encapsulate a wide range of drugs. However, the conventional methods (eg, the drop method) for synthesizing chitosan nanoparticles often face limitations in regard to controlling the particle size, morphology, and scalability, hindering their extensive application in drug delivery systems. To overcome these challenges, this study explores using a novel flow chemistry reactor design for fabricating clindamycin-loaded chitosan nanoparticles. Methods By varying two critical operating parameters of flow chemistry, namely, the flow rate ratio and total flow rate, the impact of these parameters on the properties of chitosan nanoparticles is investigated using a central composite experimental design. Results The optimized conditions for nanoparticle preparation yielded remarkable results, with chitosan nanoparticles exhibiting a small size of 371.60 nm and an extremely low polydispersity index of 0.042. Furthermore, using novel design flow chemistry reactor, the productivity of chitosan nanoparticles was estimated to be 25,402.17 mg/min, which was ~12.71 times higher than that obtained via batch synthesis. Conclusion The findings of this study indicate that the use of novel design flow chemistry reactor is promising for synthesizing clindamycin-loaded chitosan nanoparticles and other polymeric nanoparticles intended for drug delivery applications. This is primarily attributed to their ability to produce nanoparticles with a considerably reduced particle size distribution and smaller overall size. The demonstrated high productivity of this technique suggests the potential for industrial-scale nanoparticle manufacturing.

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Swallowing Gel for Patients with Dysphagia: A Novel Application of Chitosan

Cited by 5 publications

References 27 publications

Sea Fennel (Crithmum maritimum L.) as an Emerging Crop for the Manufacturing of Innovative Foods and Nutraceuticals

Sea Fennel (Crithmum maritimum L.) as an Emerging Crop for the Manufacturing of Innovative Foods and Nutraceuticals

A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges

Key Fabrications of Chitosan Nanoparticles for Effective Drug Delivery Using Flow Chemistry Reactors

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