Swallowing abnormalities and dyskinesia in Parkinson's disease

Monte, Francisca Sueli; Silva‐Júnior, Francisco Pereira da; Braga‐Neto, Pedro; Souza, Miguel Angelo N.; Bruin, Veralice Meireles Sales de

doi:10.1002/mds.20342

Cited by 102 publications

(99 citation statements)

References 26 publications

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“…SDs comprise a common complication (up to 95%) of patients with PD and are considered to be the major cause of death [9]. In patients with PD, SDs affect all three stages of swallowing, oral, pharyngeal and esophageal [10][11].…”

Section: Introductionmentioning

confidence: 99%

Anxiety, depression and swallowing disorders in patients with Parkinson's disease

Manor

Balas

Giladi

et al. 2009

Parkinsonism & Related Disorders

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Section: Introductionmentioning

confidence: 99%

Anxiety, depression and swallowing disorders in patients with Parkinson's disease

Manor

Balas

Giladi

et al. 2009

Parkinsonism & Related Disorders

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“…7 However, several reports indicate that dysphagia does not show a clear correlation with either disease duration or motor symptom severity. 5,8,9 Despite its importance, the exact nature and pathophysiology underlying PD-related dysphagia remains unclear.…”

mentioning

confidence: 99%

Cognitive and Motor Aspects of Parkinson’s Disease Associated with Dysphagia

Kim

Youn

Suh

et al. 2015

Can. J. Neurol. Sci.

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Background: Dysphagia is a common symptom and an important prognostic factor in Parkinson's disease (PD). Although cognitive and motor dysfunctions may contribute to dysphagia in patients with PD, any specific association between such problems and swallowing functions is unclear. Here, we examined the potential relationship between cognitive/motor components and swallowing functions in PD. We evaluated the contributions of cognition and motor function to the components of swallowing via video fluoroscopic swallowing (VFS) experiments. Methods: We prospectively enrolled 56 patients without dementia having PD. Parkinson's disease severity was assessed by the Unified Parkinson's Disease Rating Scale (UPDRS). All participants received neuropsychological tests covering general mental status, visuospatial function, attention, language, learning and memory, and frontal executive function. The well-validated "modified barium swallow impairment profile" scoring system was applied during VFS studies to quantify swallowing impairments. Finally, correlations between neuropsychological or motor functions and impairment in swallowing components were calculated. Results: The most significant correlations were found between the frontal/executive or learning/memory domains and the oral phase of swallowing, though a minor component of the pharyngeal phase correlated with frontal function as well. Bradykinesia and the UPDRS total score were associated with both the pharyngeal and oral phases. Conclusions: Our findings suggest that cognitive dysfunctions are associated with the oral phase of swallowing in patients with early stage PD while the severity of motor symptoms may be associated with overall swallowing function.RÉSUMÉ: Aspects cognitifs et moteurs de la maladie de Parkinson qui sont associés à la dysphagie. Contexte : La dysphagie est un symptôme fréquent de la maladie de Parkinson (MP) et constitue un facteur de prédiction important dans cette maladie. Bien que les dysfonctions cognitives et motrices puissent contribuer à la dysphagie chez les patients atteints de la MP, une association spécifique entre ces problèmes et la déglutition demeure incertaine. Nous avons examiné une relation potentielle entre les composantes cognitives/motrices et la déglutition dans la MP. Nous avons évalué la contribution de la fonction cognitive et de la fonction motrice aux différentes composantes de la déglutition au moyen de la vidéofluoroscopie (DVF). Méthode : Nous avons recruté prospectivement 56 patients atteints de la MP, sans démence. La sévérité de la MP a été évaluée au moyen de la Unified Parkinson's Disease Rating Scale (UPDRS). Tous les participants ont subi des tests neuropsychologiques évaluant l'état mental général, la fonction visuospatiale, l'attention, le langage, l'apprentissage, la mémoire ainsi que les fonctions exécutives frontales. Le système « modified barium swallow impairment profile », un système d'évaluation validé, a été utilisé au cours des études de DVF pour quantifier l'atteinte de la fonction de d...

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“…27,28 In the present cohort, 6 of 26 patients were in the SIon group, suggesting that the effect may be more common than suspected. One possible explanation is that on-phase dysphagia is similar to a dyskinetic effect of medication on the swallowing pathway.…”

Section: Swallowing Impairments In Parkinson's Diseasementioning

confidence: 65%