Sustained release from inert matrixes II. Effect of polyethylene glycols on theophylline release

Al-Shora, H. I.; Said, S. A.; Hammad, Abdul-Latif

doi:10.1016/0378-5173(80)90100-3

Cited by 4 publications

(1 citation statement)

References 4 publications

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“…These materials are readily available and expected to be relatively inexpensive, biocompatible, biodegradable and ecofriendly. Carnauba wax, due to its ease and safety of application, drug embedding ability and chemical inertness has also been used as rate retarding polymer and extensively studied by different investigators 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Sustained Release Tablet of Diltiazem Hydrochloride by Melt Granulation Technology

Ganesh¹,

Vaishali²,

Vishvanath³

et al. 2013

Int. Res. J. Pharm.

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The objective behind present study was to formulate and evaluate sustained release tablet of Diltiazem hydrochloride by using different polymers by melt granulation technology and to study the effect of various concentrations of polymers on release rate from tablet. Tablets were prepared using bees wax, carnauba wax, paraffin wax as release ratardent polymers. The drug and excipient compatibility study was done by FTIR method using KBr pellet method. The granules prepared by melt granulation technique evaluated for characterization such as bulk density, tapped density, hausners ratio, angle of repose, cars index all granules shows good flow property. The tablet of Diltiazem HCL evaluated for characterization such as hardness, friability, weight variation and content uniformity all tablets shows sufficient hardness and friability shows that tablets are having sufficient strength. All results were satisfactory. The in vitro drug release studies for the prepared formulation were conducted for a period of 12 h using an EDT 08LX dissolution tester USP Type -II apparatus (rotating paddle) set at 100 rpm and a temperature of 37 ± 0.5°C formulation was placed in the 900 ml of the medium. For first 2 h tablet was placed in 1.2 pH acidic medium which was replaced with 7.4 pH phosphate buffer for remaining 10 h. From the dissolution study and comparative graph it was concluded that increase in concentration of wax shows decrease in drug release from tablet. Batch F3 shows 99.84 % drug release at 12 h. In vitro release data of optimized formulations (Batch F3) was fitted to various kinetic models like zero order, first order, Higuchi, korsmeyer-peppas and pass Higuchi model as it has highest r 2 value (0.955) among all models.

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Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Sustained Release Tablet of Diltiazem Hydrochloride by Melt Granulation Technology

Ganesh¹,

Vaishali²,

Vishvanath³

et al. 2013

Int. Res. J. Pharm.

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Scintigraphic assessment of the in vivo dissolution rate of a sustained release tablet

Daly

Davis

Frier

et al. 1982

International Journal of Pharmaceutics

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Formulation and Release Kinetics of Sustained Release Phenylpropanolamine Hydrochloride Granules and Tablets

Hashem

El-Shaboury

Gabr

1994

Drug Development and Industrial Pharmacy

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S u :< c i! i 11 ed re 1 e a 3 c? p h en y l p r o p a n o 1 a m i n e h y d r o ch 1 I ' i de i F E ' H ) g r a : i u I r~s a n d t a b l e t s were p r e p a r e d u s i n g HI'hlC,T h e r e 1 e a s e p a t t e r n of YE11 f r V , i i t t i z p r e p a r e d g r a n u l e s a n d t a b l e t s w a s f o u n d t o b e i n the following o r d e r HPMCHPMC t SCMC > RS > R S t I .~ HPMC + I NTRODUCT I ON Although the intensity of a pharmacological effect is related to the drug concentration at the site of act-1795 Copyright 0 1994 by Marcel Dekker, Inc. Drug Dev Ind Pharm Downloaded from informahealthcare.com by University New South Wales on 08/21/15 For personal use only.

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Sustained release from inert matrixes II. Effect of polyethylene glycols on theophylline release

Cited by 4 publications

References 4 publications

Formulation and Evaluation of Sustained Release Tablet of Diltiazem Hydrochloride by Melt Granulation Technology

Formulation and Evaluation of Sustained Release Tablet of Diltiazem Hydrochloride by Melt Granulation Technology

Scintigraphic assessment of the in vivo dissolution rate of a sustained release tablet

Formulation and Release Kinetics of Sustained Release Phenylpropanolamine Hydrochloride Granules and Tablets

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